UIF_SALSA
ID UIF_SALSA Reviewed; 331 AA.
AC B5X3V2;
DT 19-JAN-2010, integrated into UniProtKB/Swiss-Prot.
DT 25-NOV-2008, sequence version 1.
DT 03-AUG-2022, entry version 27.
DE RecName: Full=UAP56-interacting factor;
DE AltName: Full=Forty-two-three domain-containing protein 1;
DE Short=Protein 40-2-3;
GN Name=fyttd1; Synonyms=uif;
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=20433749; DOI=10.1186/1471-2164-11-279;
RA Leong J.S., Jantzen S.G., von Schalburg K.R., Cooper G.A., Messmer A.M.,
RA Liao N.Y., Munro S., Moore R., Holt R.A., Jones S.J., Davidson W.S.,
RA Koop B.F.;
RT "Salmo salar and Esox lucius full-length cDNA sequences reveal changes in
RT evolutionary pressures on a post-tetraploidization genome.";
RL BMC Genomics 11:279-279(2010).
CC -!- FUNCTION: Required for mRNA export from the nucleus to the cytoplasm.
CC Acts as an adapter that uses the ddx39b/uap56-nfx1 pathway to ensure
CC efficient mRNA export and delivering to the nuclear pore (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000250}. Nucleus
CC speckle {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the UIF family. {ECO:0000305}.
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DR EMBL; BT045721; ACI33983.1; -; mRNA.
DR RefSeq; NP_001133831.1; NM_001140359.1.
DR AlphaFoldDB; B5X3V2; -.
DR PRIDE; B5X3V2; -.
DR GeneID; 100195330; -.
DR KEGG; sasa:100195330; -.
DR CTD; 100195330; -.
DR Proteomes; UP000087266; Chromosome ssa03.
DR Bgee; ENSSSAG00000050355; Expressed in brain and 15 other tissues.
DR GO; GO:0016607; C:nuclear speck; ISS:UniProtKB.
DR GO; GO:0005654; C:nucleoplasm; ISS:UniProtKB.
DR GO; GO:0003729; F:mRNA binding; ISS:UniProtKB.
DR GO; GO:0006406; P:mRNA export from nucleus; ISS:UniProtKB.
DR InterPro; IPR009782; FYTTD1.
DR PANTHER; PTHR21038; PTHR21038; 1.
PE 2: Evidence at transcript level;
KW mRNA transport; Nucleus; Reference proteome; RNA-binding; Transport.
FT CHAIN 1..331
FT /note="UAP56-interacting factor"
FT /id="PRO_0000390996"
FT REGION 30..51
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 63..99
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 158..193
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 16..34
FT /note="UAP56-binding motif"
SQ SEQUENCE 331 AA; 36662 MW; 1BC839BF49A733AA CRC64;
MSNVGFSATR GITSGAPDKV DMSLDDIIRL NKKEQQARRP SPGNRRPLQK GKVFVQGRPV
GARARGQTQR GGGVPRGAIT RAGVGRGRKI PPPVGRRRGQ GVITGLAARK TAALQKGISP
LNRPAINRKL QPFNNRSRPF NNQSRPFIQS AQYRQMQGQR RPYRQTDIQR GLNSTRPFQQ
RRRPLPPVQT QREARQATFL FRRGLKVHTQ VPKPALTSIP PAPVRPRQWR TSTNSSGILT
VSIDNPTAMT QSEPPCAWSL HPPAPTSSAP VKMKVEEEKK TEPPKGVPLQ FDINIVGKPT
AMTLNERFRI LKDERVATAQ TSKGSRFVTV G