UIP5_YEAST
ID UIP5_YEAST Reviewed; 443 AA.
AC P36137; D6VXA6;
DT 01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-1994, sequence version 1.
DT 03-AUG-2022, entry version 140.
DE RecName: Full=Protein UIP5;
DE AltName: Full=ULP1-interacting protein 5;
DE Flags: Precursor;
GN Name=UIP5; OrderedLocusNames=YKR044W;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=8196765; DOI=10.1038/369371a0;
RA Dujon B., Alexandraki D., Andre B., Ansorge W., Baladron V.,
RA Ballesta J.P.G., Banrevi A., Bolle P.-A., Bolotin-Fukuhara M., Bossier P.,
RA Bou G., Boyer J., Buitrago M.J., Cheret G., Colleaux L.,
RA Daignan-Fornier B., del Rey F., Dion C., Domdey H., Duesterhoeft A.,
RA Duesterhus S., Entian K.-D., Erfle H., Esteban P.F., Feldmann H.,
RA Fernandes L., Fobo G.M., Fritz C., Fukuhara H., Gabel C., Gaillon L.,
RA Garcia-Cantalejo J.M., Garcia-Ramirez J.J., Gent M.E., Ghazvini M.,
RA Goffeau A., Gonzalez A., Grothues D., Guerreiro P., Hegemann J.H.,
RA Hewitt N., Hilger F., Hollenberg C.P., Horaitis O., Indge K.J.,
RA Jacquier A., James C.M., Jauniaux J.-C., Jimenez A., Keuchel H.,
RA Kirchrath L., Kleine K., Koetter P., Legrain P., Liebl S., Louis E.J.,
RA Maia e Silva A., Marck C., Monnier A.-L., Moestl D., Mueller S.,
RA Obermaier B., Oliver S.G., Pallier C., Pascolo S., Pfeiffer F.,
RA Philippsen P., Planta R.J., Pohl F.M., Pohl T.M., Poehlmann R.,
RA Portetelle D., Purnelle B., Puzos V., Ramezani Rad M., Rasmussen S.W.,
RA Remacha M.A., Revuelta J.L., Richard G.-F., Rieger M.,
RA Rodrigues-Pousada C., Rose M., Rupp T., Santos M.A., Schwager C.,
RA Sensen C., Skala J., Soares H., Sor F., Stegemann J., Tettelin H.,
RA Thierry A., Tzermia M., Urrestarazu L.A., van Dyck L.,
RA van Vliet-Reedijk J.C., Valens M., Vandenbol M., Vilela C., Vissers S.,
RA von Wettstein D., Voss H., Wiemann S., Xu G., Zimmermann J., Haasemann M.,
RA Becker I., Mewes H.-W.;
RT "Complete DNA sequence of yeast chromosome XI.";
RL Nature 369:371-378(1994).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=17322287; DOI=10.1101/gr.6037607;
RA Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J.,
RA Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J.,
RA Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D.,
RA LaBaer J.;
RT "Approaching a complete repository of sequence-verified protein-encoding
RT clones for Saccharomyces cerevisiae.";
RL Genome Res. 17:536-543(2007).
RN [4]
RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX PubMed=14562106; DOI=10.1038/nature02046;
RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA O'Shea E.K., Weissman J.S.;
RT "Global analysis of protein expression in yeast.";
RL Nature 425:737-741(2003).
RN [5]
RP TOPOLOGY [LARGE SCALE ANALYSIS].
RC STRAIN=ATCC 208353 / W303-1A;
RX PubMed=16847258; DOI=10.1073/pnas.0604075103;
RA Kim H., Melen K., Oesterberg M., von Heijne G.;
RT "A global topology map of the Saccharomyces cerevisiae membrane proteome.";
RL Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006).
CC -!- SUBCELLULAR LOCATION: Nucleus membrane; Single-pass type I membrane
CC protein.
CC -!- MISCELLANEOUS: Present with 319 molecules/cell in log phase SD medium.
CC {ECO:0000269|PubMed:14562106}.
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DR EMBL; Z28269; CAA82120.1; -; Genomic_DNA.
DR EMBL; AY723841; AAU09758.1; -; Genomic_DNA.
DR EMBL; BK006944; DAA09196.1; -; Genomic_DNA.
DR PIR; S38116; S38116.
DR RefSeq; NP_012970.3; NM_001179834.3.
DR AlphaFoldDB; P36137; -.
DR SMR; P36137; -.
DR BioGRID; 34176; 32.
DR DIP; DIP-4845N; -.
DR IntAct; P36137; 1.
DR STRING; 4932.YKR044W; -.
DR iPTMnet; P36137; -.
DR PaxDb; P36137; -.
DR PRIDE; P36137; -.
DR EnsemblFungi; YKR044W_mRNA; YKR044W; YKR044W.
DR GeneID; 853918; -.
DR KEGG; sce:YKR044W; -.
DR SGD; S000001752; UIP5.
DR VEuPathDB; FungiDB:YKR044W; -.
DR eggNOG; ENOG502QVEK; Eukaryota.
DR GeneTree; ENSGT00940000171755; -.
DR HOGENOM; CLU_050744_0_0_1; -.
DR InParanoid; P36137; -.
DR OMA; MGFPKNL; -.
DR BioCyc; YEAST:G3O-32015-MON; -.
DR Reactome; R-SCE-9013106; RHOC GTPase cycle.
DR PRO; PR:P36137; -.
DR Proteomes; UP000002311; Chromosome XI.
DR RNAct; P36137; protein.
DR GO; GO:0030134; C:COPII-coated ER to Golgi transport vesicle; IBA:GO_Central.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IBA:GO_Central.
DR GO; GO:0005793; C:endoplasmic reticulum-Golgi intermediate compartment; IBA:GO_Central.
DR GO; GO:0000324; C:fungal-type vacuole; HDA:SGD.
DR GO; GO:0000139; C:Golgi membrane; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005635; C:nuclear envelope; IDA:SGD.
DR GO; GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005537; F:mannose binding; IBA:GO_Central.
DR GO; GO:0007029; P:endoplasmic reticulum organization; IBA:GO_Central.
DR GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IBA:GO_Central.
DR GO; GO:0007030; P:Golgi organization; IBA:GO_Central.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR005052; Lectin_leg.
DR Pfam; PF03388; Lectin_leg-like; 2.
DR SUPFAM; SSF49899; SSF49899; 1.
PE 1: Evidence at protein level;
KW Membrane; Nucleus; Reference proteome; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..27
FT /evidence="ECO:0000255"
FT CHAIN 28..443
FT /note="Protein UIP5"
FT /id="PRO_0000203212"
FT TOPO_DOM 28..398
FT /note="Perinuclear space"
FT /evidence="ECO:0000255"
FT TRANSMEM 399..420
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 421..443
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
SQ SEQUENCE 443 AA; 50981 MW; 360A0117AC2667A2 CRC64;
MSRDVRAEKL AISLLILSLF LIFQLVAEIY LNNGDQYHTE TSPFTRGRSH VTRVPNHDAS
LSIPFLDKIN QFWHVGGATQ IRNIQSIKLT QDRDQDKHGL VLSNGIGDNT INDFEIVFTF
RISHDPTTQL TGDGMCFAIT PENGFLTQNL QSSYAKKQYM MNSQGVIADN TDLMGFPKNL
PGLFIVLDTY RNQGHDHKEV PFMDVFINVA PESDWYDINS DGELSTSLRL NSRGHIKLKK
NALWNRVTKL RIIYLESISF LKIDVQYAKE GNYWIELFQT TENLYLPKNM HTGQRYIGCS
ALNGQLTETV ELLDVSTSEF HWNDMDASIE DTYDYAKEAE LFLEQEFGEV LDREPDEFTK
WKMIKAQPNI KTGSQSAEQK TSNNPHSRLF KVVLTIWHYS EILLLIMGIY LFSACIRVFQ
RRFKKIRSRR KRAGSHSVGL LPM
