ID   UL05_HCMVA              Reviewed;         166 AA.
AC   P16776; Q7M6N4;
DT   01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1990, sequence version 1.
DT   03-AUG-2022, entry version 53.
DE   RecName: Full=Protein UL5;
GN   Name=UL5;
OS   Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Cytomegalovirus.
OX   NCBI_TaxID=10360;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=2161319; DOI=10.1007/978-3-642-74980-3_6;
RA   Chee M.S., Bankier A.T., Beck S., Bohni R., Brown C.M., Cerny R.,
RA   Horsnell T., Hutchison C.A. III, Kouzarides T., Martignetti J.A.,
RA   Preddie E., Satchwell S.C., Tomlinson P., Weston K.M., Barrell B.G.;
RT   "Analysis of the protein-coding content of the sequence of human
RT   cytomegalovirus strain AD169.";
RL   Curr. Top. Microbiol. Immunol. 154:125-169(1990).
RN   [2]
RP   GENOME REANNOTATION.
RX   PubMed=12533697; DOI=10.1099/vir.0.18606-0;
RA   Davison A.J., Dolan A., Akter P., Addison C., Dargan D.J., Alcendor D.J.,
RA   McGeoch D.J., Hayward G.S.;
RT   "The human cytomegalovirus genome revisited: comparison with the chimpanzee
RT   cytomegalovirus genome.";
RL   J. Gen. Virol. 84:17-28(2003).
RN   [3]
RP   ERRATUM OF PUBMED:12533697.
RA   Davison A.J., Dolan A., Akter P., Addison C., Dargan D.J., Alcendor D.J.,
RA   McGeoch D.J., Hayward G.S.;
RL   J. Gen. Virol. 84:1053-1053(2003).
RN   [4]
RP   IDENTIFICATION.
RX   PubMed=15452216; DOI=10.1128/jvi.78.20.10960-10966.2004;
RA   Varnum S.M., Streblow D.N., Monroe M.E., Smith P., Auberry K.J.,
RA   Pasa-Tolic L., Wang D., Camp D.G. II, Rodland K., Wiley S., Britt W.,
RA   Shenk T., Smith R.D., Nelson J.A.;
RT   "Identification of proteins in human cytomegalovirus (HCMV) particles: the
RT   HCMV proteome.";
RL   J. Virol. 78:10960-10966(2004).
RN   [5]
RP   ERRATUM OF PUBMED:15452216.
RA   Varnum S.M., Streblow D.N., Monroe M.E., Smith P., Auberry K.J.,
RA   Pasa-Tolic L., Wang D., Camp D.G. II, Rodland K., Wiley S., Britt W.,
RA   Shenk T., Smith R.D., Nelson J.A.;
RL   J. Virol. 78:13395-13395(2004).
RN   [6]
RP   FUNCTION, INTERACTION WITH HOST IQGAP1, AND SUBCELLULAR LOCATION.
RX   PubMed=31739185; DOI=10.1016/j.virol.2019.10.018;
RA   Anselmi G., Giuliani M., Vezzani G., Ferranti R., Gentile M., Cortese M.,
RA   Amendola D., Pacchiani N., D'Aurizio R., Bruno L., Uematsu Y., Merola M.,
RA   Maione D.;
RT   "Characterization of pUL5, an HCMV protein interacting with the cellular
RT   protein IQGAP1.";
RL   Virology 540:57-65(2020).
CC   -!- FUNCTION: May play a role in rearrangement of cellular cytoskeleton
CC       towards an efficient viral assembly and spreading.
CC       {ECO:0000269|PubMed:31739185}.
CC   -!- SUBUNIT: Interacts with host IQGAP1. {ECO:0000269|PubMed:31739185}.
CC   -!- SUBCELLULAR LOCATION: Host cytoplasm {ECO:0000269|PubMed:31739185}.
CC       Note=Localizes within the assembly compartments within host cytoplasm,
CC       but is not incorporated in the virion. {ECO:0000269|PubMed:31739185}.
CC   -!- SIMILARITY: Belongs to the RL11 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; X17403; CAA35438.1; -; Genomic_DNA.
DR   EMBL; BK000394; DAA00154.1; -; Genomic_DNA.
DR   PIR; S09768; S09768.
DR   Proteomes; UP000008991; Genome.
DR   Proteomes; UP000008992; Genome.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   InterPro; IPR016497; Herpes_UL5.
DR   PIRSF; PIRSF006846; UCP006846_UL5; 1.
PE   1: Evidence at protein level;
KW   Host cytoplasm; Host-virus interaction; Reference proteome.
FT   CHAIN           1..166
FT                   /note="Protein UL5"
FT                   /id="PRO_0000115302"
SQ   SEQUENCE   166 AA;  18860 MW;  1BBB839D270D5BBA CRC64;
     MFLGYSDCVD PGLAVYRVSR SRLKLVLSFV WLVGLRLHDC AAFESCCYDI TEAESNKAIS
     RDKAAFTSSV STRTPSLAIA PPPDRSMLLS REEELVPWSR LIITKQFYGG LIFHTTWVTG
     FVLLGLLTLF ASLFRVPQSI CRFCIDRLRD IARPLKYRYQ RLVATV