CA141_HUMAN
ID CA141_HUMAN Reviewed; 400 AA.
AC Q5JVX7; Q0P5P5; Q5JVX5;
DT 10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 15-FEB-2005, sequence version 1.
DT 03-AUG-2022, entry version 101.
DE RecName: Full=Uncharacterized protein C1orf141;
GN Name=C1orf141;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), AND VARIANT
RP ILE-189.
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q5JVX7-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q5JVX7-2; Sequence=VSP_026643, VSP_026644;
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DR EMBL; AL133320; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC047053; AAH47053.1; -; mRNA.
DR EMBL; BC090886; AAH90886.1; -; mRNA.
DR CCDS; CCDS30745.1; -. [Q5JVX7-1]
DR RefSeq; NP_001263280.1; NM_001276351.1. [Q5JVX7-1]
DR AlphaFoldDB; Q5JVX7; -.
DR SMR; Q5JVX7; -.
DR BioGRID; 134747; 3.
DR STRING; 9606.ENSP00000360046; -.
DR iPTMnet; Q5JVX7; -.
DR PhosphoSitePlus; Q5JVX7; -.
DR BioMuta; C1orf141; -.
DR DMDM; 74742495; -.
DR EPD; Q5JVX7; -.
DR MaxQB; Q5JVX7; -.
DR PaxDb; Q5JVX7; -.
DR PeptideAtlas; Q5JVX7; -.
DR PRIDE; Q5JVX7; -.
DR Antibodypedia; 33403; 49 antibodies from 11 providers.
DR DNASU; 400757; -.
DR Ensembl; ENST00000371006.5; ENSP00000360045.1; ENSG00000203963.12. [Q5JVX7-1]
DR Ensembl; ENST00000371007.6; ENSP00000360046.1; ENSG00000203963.12. [Q5JVX7-1]
DR Ensembl; ENST00000621590.4; ENSP00000481294.1; ENSG00000203963.12. [Q5JVX7-2]
DR Ensembl; ENST00000684719.1; ENSP00000507487.1; ENSG00000203963.12. [Q5JVX7-1]
DR GeneID; 400757; -.
DR KEGG; hsa:400757; -.
DR MANE-Select; ENST00000684719.1; ENSP00000507487.1; NM_001276351.2; NP_001263280.1.
DR UCSC; uc057hjb.1; human. [Q5JVX7-1]
DR CTD; 400757; -.
DR DisGeNET; 400757; -.
DR GeneCards; C1orf141; -.
DR HGNC; HGNC:32044; C1orf141.
DR HPA; ENSG00000203963; Tissue enhanced (fallopian tube, testis).
DR neXtProt; NX_Q5JVX7; -.
DR OpenTargets; ENSG00000203963; -.
DR PharmGKB; PA142672459; -.
DR VEuPathDB; HostDB:ENSG00000203963; -.
DR eggNOG; ENOG502SCCV; Eukaryota.
DR GeneTree; ENSGT00390000010146; -.
DR HOGENOM; CLU_058935_0_0_1; -.
DR InParanoid; Q5JVX7; -.
DR OMA; TFENISW; -.
DR OrthoDB; 714297at2759; -.
DR PhylomeDB; Q5JVX7; -.
DR TreeFam; TF340010; -.
DR PathwayCommons; Q5JVX7; -.
DR BioGRID-ORCS; 400757; 4 hits in 1034 CRISPR screens.
DR ChiTaRS; C1orf141; human.
DR GenomeRNAi; 400757; -.
DR Pharos; Q5JVX7; Tdark.
DR PRO; PR:Q5JVX7; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q5JVX7; protein.
DR Bgee; ENSG00000203963; Expressed in right uterine tube and 50 other tissues.
DR ExpressionAtlas; Q5JVX7; baseline and differential.
DR InterPro; IPR027847; DUF4545.
DR PANTHER; PTHR36873; PTHR36873; 2.
DR Pfam; PF15078; DUF4545; 2.
PE 2: Evidence at transcript level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..400
FT /note="Uncharacterized protein C1orf141"
FT /id="PRO_0000294456"
FT REGION 112..151
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 113..147
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 78..80
FT /note="MHV -> ISN (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_026643"
FT VAR_SEQ 81..400
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_026644"
FT VARIANT 85
FT /note="E -> G (in dbSNP:rs2273682)"
FT /id="VAR_033186"
FT VARIANT 189
FT /note="V -> I (in dbSNP:rs11208997)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_033187"
SQ SEQUENCE 400 AA; 46135 MW; 3CABE4023A1B7310 CRC64;
MAEKILEKLD VLDKQAEIIL ARRTKINRLQ SEGRKTTMAI PLTFDFQLEF EEALATSASK
AISKIKEDKS CSITKSKMHV SFKCEPEPRK SNFEKSNLRP FFIQTNVKNK ESESTAQIEK
KPRKPLDSVG LLEGDRNKRK KSPQMNDFNI KENKSVRNYQ LSKYRSVRKK SLLPLCFEDE
LKNPHAKIVN VSPTKTVTSH MEQKDTNPII FHDTEYVRML LLTKNRFSSH PLENENIYPH
KRTNFILERN CEILKSIIGN QSISLFKPQK TMPTVQRKDI QIPMSFKAGH TTVDDKLKKK
TNKQTLENRS WNTLYNFSQN FSSLTKQFVG YLDKAVIHEM SAQTGKFERM FSAGKPTSIP
TSSALPVKCY SKPFKYIYEL NNVTPLDNLL NLSNEILNAS
