UL07_HCMVA
ID UL07_HCMVA Reviewed; 222 AA.
AC P16743; Q7M6M3;
DT 01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1990, sequence version 1.
DT 03-AUG-2022, entry version 84.
DE RecName: Full=CEACAM1-like protein UL7;
GN Name=UL7;
OS Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5).
OC Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC Herpesvirales; Herpesviridae; Betaherpesvirinae; Cytomegalovirus.
OX NCBI_TaxID=10360;
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=2161319; DOI=10.1007/978-3-642-74980-3_6;
RA Chee M.S., Bankier A.T., Beck S., Bohni R., Brown C.M., Cerny R.,
RA Horsnell T., Hutchison C.A. III, Kouzarides T., Martignetti J.A.,
RA Preddie E., Satchwell S.C., Tomlinson P., Weston K.M., Barrell B.G.;
RT "Analysis of the protein-coding content of the sequence of human
RT cytomegalovirus strain AD169.";
RL Curr. Top. Microbiol. Immunol. 154:125-169(1990).
RN [2]
RP GENOME REANNOTATION.
RX PubMed=12533697; DOI=10.1099/vir.0.18606-0;
RA Davison A.J., Dolan A., Akter P., Addison C., Dargan D.J., Alcendor D.J.,
RA McGeoch D.J., Hayward G.S.;
RT "The human cytomegalovirus genome revisited: comparison with the chimpanzee
RT cytomegalovirus genome.";
RL J. Gen. Virol. 84:17-28(2003).
RN [3]
RP ERRATUM OF PUBMED:12533697.
RA Davison A.J., Dolan A., Akter P., Addison C., Dargan D.J., Alcendor D.J.,
RA McGeoch D.J., Hayward G.S.;
RL J. Gen. Virol. 84:1053-1053(2003).
RN [4]
RP GENE FAMILY.
RX PubMed=12604818; DOI=10.1099/vir.0.18856-0;
RA Davison A.J., Akter P., Cunningham C., Dolan A., Addison C., Dargan D.J.,
RA Hassan-Walker A.F., Emery V.C., Griffiths P.D., Wilkinson G.W.;
RT "Homology between the human cytomegalovirus RL11 gene family and human
RT adenovirus E3 genes.";
RL J. Gen. Virol. 84:657-663(2003).
RN [5]
RP FUNCTION, SUBCELLULAR LOCATION, AND GLYCOSYLATION.
RX PubMed=21670740; DOI=10.1038/icb.2011.55;
RA Engel P., Perez-Carmona N., Alba M.M., Robertson K., Ghazal P., Angulo A.;
RT "Human cytomegalovirus UL7, a homologue of the SLAM-family receptor CD229,
RT impairs cytokine production.";
RL Immunol. Cell Biol. 89:753-766(2011).
RN [6]
RP FUNCTION, AND INTERACTION WITH HOST FLT3.
RX PubMed=29691342; DOI=10.1128/mbio.00682-18;
RA Crawford L.B., Kim J.H., Collins-McMillen D., Lee B.J., Landais I.,
RA Held C., Nelson J.A., Yurochko A.D., Caposio P.;
RT "Human Cytomegalovirus Encodes a Novel FLT3 Receptor Ligand Necessary for
RT Hematopoietic Cell Differentiation and Viral Reactivation.";
RL MBio 9:0-0(2018).
CC -!- FUNCTION: Plays a role in modulating the host immune response and
CC affecting host cytokine production. Structurally and functionally
CC homolog of host CEACAM1, induces endothelial cell angiogenesis
CC (PubMed:21670740). Ligands for host FLT3 receptor, activates the
CC PI3K/AKT and MAPK/ERK pathways. In turn, triggers hematopoietic
CC progenitor cell and monocyte differentiation leading to virus
CC reactivation (PubMed:29691342). {ECO:0000250|UniProtKB:Q6SWC3,
CC ECO:0000269|PubMed:21670740, ECO:0000269|PubMed:29691342}.
CC -!- SUBUNIT: Interacts with host FLT3. {ECO:0000269|PubMed:29691342}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q6SWC3}. Host
CC cell membrane {ECO:0000269|PubMed:21670740}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- PTM: Highly glycosylated. {ECO:0000269|PubMed:21670740}.
CC -!- SIMILARITY: Belongs to the RL11 family. {ECO:0000269|PubMed:12604818}.
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DR EMBL; X17403; CAA35440.1; -; Genomic_DNA.
DR EMBL; BK000394; DAA00165.1; -; Genomic_DNA.
DR PIR; S09770; S09770.
DR SMR; P16743; -.
DR TCDB; 9.B.410.2.5; the viral e3 cr1 (e3-cr1) family.
DR PRIDE; P16743; -.
DR Proteomes; UP000008991; Genome.
DR Proteomes; UP000008992; Genome.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0039673; P:evasion by virus of host dendritic cell activity; IEA:UniProtKB-KW.
DR Gene3D; 2.60.40.10; -; 1.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR SUPFAM; SSF48726; SSF48726; 1.
PE 1: Evidence at protein level;
KW Glycoprotein; Host cell membrane; Host membrane; Host-virus interaction;
KW Membrane; Modulation of host dendritic cell activity by virus;
KW Reference proteome; Secreted; Transmembrane; Transmembrane helix;
KW Viral immunoevasion.
FT CHAIN 1..222
FT /note="CEACAM1-like protein UL7"
FT /id="PRO_0000115304"
FT TRANSMEM 193..213
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CARBOHYD 50
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT CARBOHYD 56
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT CARBOHYD 60
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT CARBOHYD 71
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT CARBOHYD 105
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT CARBOHYD 109
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT CARBOHYD 125
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT CARBOHYD 132
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT CARBOHYD 147
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT CARBOHYD 164
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT CARBOHYD 168
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT CARBOHYD 189
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
SQ SEQUENCE 222 AA; 24353 MW; 975B5E443B16C8FE CRC64;
MASDVSSHLL TVTQSRWTIH HMYNKLLILA LFTPVILESI IYVSGPQGGN VTLVSNFTSN
ISARWFRWDG NDSHLICFYK RGEGLSTPYV GLSLSCAANQ ITIFNLTLND SGRYGAEGFT
RSGENETFLW YNLTVKPKPL ETTTASNVTT IVTTTPTVIG TKSNVTGNAS LAPQLRAVAG
FLNQTPRENN THLALVGVIV FIALIVVCIM GWWKLLCSKP KL
