ID   UL07_HCMVM              Reviewed;         222 AA.
AC   Q6SWC3; D2K3H7;
DT   13-JUN-2012, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   23-FEB-2022, entry version 72.
DE   RecName: Full=CEACAM1-like protein UL7;
GN   Name=UL7;
OS   Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Cytomegalovirus.
OX   NCBI_TaxID=295027;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15105547; DOI=10.1099/vir.0.79888-0;
RA   Dolan A., Cunningham C., Hector R.D., Hassan-Walker A.F., Lee L.,
RA   Addison C., Dargan D.J., McGeoch D.J., Gatherer D., Emery V.C.,
RA   Griffiths P.D., Sinzger C., McSharry B.P., Wilkinson G.W.G., Davison A.J.;
RT   "Genetic content of wild-type human cytomegalovirus.";
RL   J. Gen. Virol. 85:1301-1312(2004).
RN   [2]
RP   FUNCTION, AND SUBCELLULAR LOCATION.
RX   PubMed=25352622; DOI=10.1128/mbio.02035-14;
RA   MacManiman J.D., Meuser A., Botto S., Smith P.P., Liu F., Jarvis M.A.,
RA   Nelson J.A., Caposio P.;
RT   "Human cytomegalovirus-encoded pUL7 is a novel CEACAM1-like molecule
RT   responsible for promotion of angiogenesis.";
RL   MBio 5:E02035-E02035(2014).
CC   -!- FUNCTION: Plays a role in modulating the host immune response and
CC       affecting host cytokine production. Structurally and functionally
CC       homolog of host CEACAM1, induces endothelial cell angiogenesis.
CC       {ECO:0000269|PubMed:25352622}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:25352622}. Host cell
CC       membrane {ECO:0000250|UniProtKB:P16743}; Single-pass membrane protein
CC       {ECO:0000305}.
CC   -!- PTM: Highly glycosylated. {ECO:0000250|UniProtKB:P16743}.
CC   -!- SIMILARITY: Belongs to the RL11 family. {ECO:0000305}.
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DR   EMBL; AY446894; AAR31573.1; -; Genomic_DNA.
DR   RefSeq; YP_081467.1; NC_006273.2.
DR   SMR; Q6SWC3; -.
DR   PRIDE; Q6SWC3; -.
DR   DNASU; 3077480; -.
DR   GeneID; 3077480; -.
DR   KEGG; vg:3077480; -.
DR   Reactome; R-HSA-9610379; HCMV Late Events.
DR   Proteomes; UP000000938; Genome.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0039673; P:evasion by virus of host dendritic cell activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.10; -; 1.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   SUPFAM; SSF48726; SSF48726; 1.
PE   3: Inferred from homology;
KW   Glycoprotein; Host cell membrane; Host membrane; Host-virus interaction;
KW   Membrane; Modulation of host dendritic cell activity by virus;
KW   Reference proteome; Secreted; Transmembrane; Transmembrane helix;
KW   Viral immunoevasion.
FT   CHAIN           1..222
FT                   /note="CEACAM1-like protein UL7"
FT                   /id="PRO_0000417835"
FT   TRANSMEM        193..213
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        50
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        56
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        60
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        71
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        105
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        109
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        125
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        132
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        147
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        164
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        168
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        189
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   222 AA;  24322 MW;  13B625E689AC5013 CRC64;
     MASDVGSHPL TVTRFRCRVH YVYNKLLILT LFAPVILESV IYVSGPQGGN VTLVSNFTSN
     ISARWFRWDG NDSHLICFYK RGEGLSTPYV GLSLSCAANQ ITIFNLTLND SGRYGAEGFT
     RSGENETFLW YNLTVKPKPL ETTPASNVTT IVTTTSTVTD AKSNVTGNVS LAPQLRAVAG
     FSHQTPLENN THLALVGVVV FLVLIVVCIM GWWKLLCSKS EL