ID   UL08_HCMVA              Reviewed;         324 AA.
AC   P16744; B8YE45; Q7M6L2;
DT   01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT   12-SEP-2018, sequence version 2.
DT   03-AUG-2022, entry version 55.
DE   RecName: Full=Membrane protein UL8;
GN   Name=UL8;
OS   Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Cytomegalovirus.
OX   NCBI_TaxID=10360;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=2161319; DOI=10.1007/978-3-642-74980-3_6;
RA   Chee M.S., Bankier A.T., Beck S., Bohni R., Brown C.M., Cerny R.,
RA   Horsnell T., Hutchison C.A. III, Kouzarides T., Martignetti J.A.,
RA   Preddie E., Satchwell S.C., Tomlinson P., Weston K.M., Barrell B.G.;
RT   "Analysis of the protein-coding content of the sequence of human
RT   cytomegalovirus strain AD169.";
RL   Curr. Top. Microbiol. Immunol. 154:125-169(1990).
RN   [2]
RP   GENOME REANNOTATION.
RX   PubMed=12533697; DOI=10.1099/vir.0.18606-0;
RA   Davison A.J., Dolan A., Akter P., Addison C., Dargan D.J., Alcendor D.J.,
RA   McGeoch D.J., Hayward G.S.;
RT   "The human cytomegalovirus genome revisited: comparison with the chimpanzee
RT   cytomegalovirus genome.";
RL   J. Gen. Virol. 84:17-28(2003).
RN   [3]
RP   ERRATUM OF PUBMED:12533697.
RA   Davison A.J., Dolan A., Akter P., Addison C., Dargan D.J., Alcendor D.J.,
RA   McGeoch D.J., Hayward G.S.;
RL   J. Gen. Virol. 84:1053-1053(2003).
RN   [4]
RP   GENE FAMILY.
RX   PubMed=12604818; DOI=10.1099/vir.0.18856-0;
RA   Davison A.J., Akter P., Cunningham C., Dolan A., Addison C., Dargan D.J.,
RA   Hassan-Walker A.F., Emery V.C., Griffiths P.D., Wilkinson G.W.;
RT   "Homology between the human cytomegalovirus RL11 gene family and human
RT   adenovirus E3 genes.";
RL   J. Gen. Virol. 84:657-663(2003).
RN   [5]
RP   FUNCTION, SUBCELLULAR LOCATION, AND GLYCOSYLATION.
RX   PubMed=29467314; DOI=10.1128/jvi.02229-17;
RA   Perez-Carmona N., Martinez-Vicente P., Farre D., Gabaev I., Messerle M.,
RA   Engel P., Angulo A.;
RT   "A prominent role of the human cytomegalovirus UL8 glycoprotein restraining
RT   pro-inflammatory cytokine production by myeloid cells at late times during
RT   infection.";
RL   J. Virol. 0:0-0(2018).
CC   -!- FUNCTION: Plays a role in the inhibition of pro-inflammatory cytokine
CC       prodution. This effect is mediated by the conserved Ig-like domain.
CC       {ECO:0000269|PubMed:29467314}.
CC   -!- SUBCELLULAR LOCATION: Host cell membrane {ECO:0000269|PubMed:29467314};
CC       Single-pass membrane protein {ECO:0000255}.
CC   -!- INDUCTION: Expressed at late times of infection.
CC       {ECO:0000269|PubMed:29467314}.
CC   -!- PTM: Highly glycosylated. {ECO:0000269|PubMed:29467314}.
CC   -!- SIMILARITY: Belongs to the RL11 family. {ECO:0000269|PubMed:12604818}.
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DR   EMBL; X17403; CAA35441.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; BK000394; DAA00176.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; FJ527563; ACL51089.2; -; Genomic_DNA.
DR   PIR; S09771; S09771.
DR   SMR; P16744; -.
DR   PRIDE; P16744; -.
DR   Proteomes; UP000008991; Genome.
DR   Proteomes; UP000008992; Genome.
DR   Proteomes; UP000180728; Genome.
DR   GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.10; -; 1.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   SUPFAM; SSF48726; SSF48726; 1.
PE   1: Evidence at protein level;
KW   Glycoprotein; Host cell membrane; Host membrane; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..324
FT                   /note="Membrane protein UL8"
FT                   /id="PRO_0000115305"
FT   TRANSMEM        278..298
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          36..138
FT                   /note="Immunoglobulin V-like domain"
FT                   /evidence="ECO:0000269|PubMed:29467314"
SQ   SEQUENCE   324 AA;  35797 MW;  E3EAEB9701AE9EDB CRC64;
     MASDVSSHLL TVTQSRWTIH HMYNKLLILA LFTPVILESI IYVSGPQGGN VTLVSNFTSN
     ISARWFRWDG NDSHLICFYK RGEGLSTPYV GLSLSCAANQ ITIFNLTLND SGRYGAEGFT
     RSGENETFLW YNLTVKPKPL ETTTASNVTT IVTTTPTVIG TKSNVTGNAS LAPQLRAVAG
     FLNQTPRENN THLALGEGFV PTMTNPGLYA SENYNGNYEL TEAANTARTN SSDWVTLGTS
     ASLLRSTETA VNPSNATTVT PQPVEYPAGE VQYQRTKTHY SWMLIIAIIL IIFIIICLRA
     PQKVYDRWKD NKQYGQVFMT DTEL