CA141_MOUSE
ID CA141_MOUSE Reviewed; 446 AA.
AC Q9D5Q8; A2AKQ4; Q3KN93; Q3KN94; Q3TTD9;
DT 10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 102.
DE RecName: Full=Uncharacterized protein C1orf141 homolog;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q9D5Q8-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9D5Q8-2; Sequence=VSP_026645;
CC Name=3;
CC IsoId=Q9D5Q8-3; Sequence=VSP_026646, VSP_026647;
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DR EMBL; AK015018; BAB29675.1; -; mRNA.
DR EMBL; AK161421; BAE36386.1; -; mRNA.
DR EMBL; AL772338; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC107404; AAI07405.1; -; mRNA.
DR EMBL; BC107405; AAI07406.1; -; mRNA.
DR CCDS; CCDS51247.1; -. [Q9D5Q8-2]
DR CCDS; CCDS51248.1; -. [Q9D5Q8-1]
DR RefSeq; NP_001156966.1; NM_001163494.1. [Q9D5Q8-2]
DR RefSeq; NP_081888.1; NM_027612.1. [Q9D5Q8-1]
DR AlphaFoldDB; Q9D5Q8; -.
DR STRING; 10090.ENSMUSP00000030245; -.
DR iPTMnet; Q9D5Q8; -.
DR PhosphoSitePlus; Q9D5Q8; -.
DR PaxDb; Q9D5Q8; -.
DR PRIDE; Q9D5Q8; -.
DR Antibodypedia; 33403; 49 antibodies from 11 providers.
DR Ensembl; ENSMUST00000030245; ENSMUSP00000030245; ENSMUSG00000028520. [Q9D5Q8-1]
DR Ensembl; ENSMUST00000097944; ENSMUSP00000095557; ENSMUSG00000028520. [Q9D5Q8-3]
DR Ensembl; ENSMUST00000168664; ENSMUSP00000131846; ENSMUSG00000028520. [Q9D5Q8-2]
DR GeneID; 70941; -.
DR KEGG; mmu:70941; -.
DR UCSC; uc008txp.3; mouse. [Q9D5Q8-1]
DR MGI; MGI:1918191; 4921539E11Rik.
DR VEuPathDB; HostDB:ENSMUSG00000028520; -.
DR eggNOG; ENOG502SCCV; Eukaryota.
DR GeneTree; ENSGT00390000010146; -.
DR HOGENOM; CLU_058935_0_0_1; -.
DR InParanoid; Q9D5Q8; -.
DR OMA; TFENISW; -.
DR OrthoDB; 714297at2759; -.
DR PhylomeDB; Q9D5Q8; -.
DR TreeFam; TF340010; -.
DR BioGRID-ORCS; 70941; 1 hit in 72 CRISPR screens.
DR PRO; PR:Q9D5Q8; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; Q9D5Q8; protein.
DR Bgee; ENSMUSG00000028520; Expressed in seminiferous tubule of testis and 8 other tissues.
DR Genevisible; Q9D5Q8; MM.
DR InterPro; IPR027847; DUF4545.
DR PANTHER; PTHR36873; PTHR36873; 1.
DR Pfam; PF15078; DUF4545; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..446
FT /note="Uncharacterized protein C1orf141 homolog"
FT /id="PRO_0000294457"
FT REGION 63..95
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 155..232
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 158..177
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 178..196
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 211..230
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..101
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_026645"
FT VAR_SEQ 266..283
FT /note="KQSHANPIIFYDTEYVQM -> AVINNFEAGEDRHFVRLL (in isoform
FT 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_026646"
FT VAR_SEQ 284..446
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_026647"
FT CONFLICT 313
FT /note="V -> A (in Ref. 3; AAI07405/AAI07406)"
FT /evidence="ECO:0000305"
FT CONFLICT 353
FT /note="R -> H (in Ref. 3; AAI07405/AAI07406)"
FT /evidence="ECO:0000305"
FT CONFLICT 364
FT /note="R -> H (in Ref. 3; AAI07405/AAI07406)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 446 AA; 51672 MW; FEA967E3B4919AA4 CRC64;
MTEKILEKFD ALEEKERILE AIRENNTDRH HRQRKKPLIT PLLFDLHVQF GDTITPSASK
IIKNKPHDLK NPKRSVSFKY KPNNSRSDLE ESDLRPPILG TMINYEESKL MDHKEENLKS
RPISLRYLKD KDETEYANPL PFPQLWSKHL CKKSAESSVP TPKLTNESNA SKKENVSPPF
TDQHESRTKK SMHSTDHSAD SSTSRGKCPP KGITKESELT RNDEARKPHP VKQSIMLPLD
CEDLLKNPKI KTIDLRPAVT VHTSMKQSHA NPIIFYDTEY VQMLFLTKRF TPYAMKCTER
NIVLEKNYEV LKVLFSDEPS AVSEPIQQKH LQVFSAEYAQ KSINEKRKKK HDRLVSKKIS
PNTRYNLSQT FSSLSKKFVG YFDKDVTQGK SYKANRFERF SKTKPPPTRK LTTLPIKYDS
KPLKNIFEIH KLNNMTPLDN LLGLRA
