ID   UL117_HCMVA             Reviewed;         424 AA.
AC   P16770; Q7M6S8;
DT   01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1990, sequence version 1.
DT   23-FEB-2022, entry version 62.
DE   RecName: Full=Protein UL117;
GN   Name=UL117;
OS   Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Cytomegalovirus.
OX   NCBI_TaxID=10360;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=2161319; DOI=10.1007/978-3-642-74980-3_6;
RA   Chee M.S., Bankier A.T., Beck S., Bohni R., Brown C.M., Cerny R.,
RA   Horsnell T., Hutchison C.A. III, Kouzarides T., Martignetti J.A.,
RA   Preddie E., Satchwell S.C., Tomlinson P., Weston K.M., Barrell B.G.;
RT   "Analysis of the protein-coding content of the sequence of human
RT   cytomegalovirus strain AD169.";
RL   Curr. Top. Microbiol. Immunol. 154:125-169(1990).
RN   [2]
RP   GENOME REANNOTATION.
RX   PubMed=12533697; DOI=10.1099/vir.0.18606-0;
RA   Davison A.J., Dolan A., Akter P., Addison C., Dargan D.J., Alcendor D.J.,
RA   McGeoch D.J., Hayward G.S.;
RT   "The human cytomegalovirus genome revisited: comparison with the chimpanzee
RT   cytomegalovirus genome.";
RL   J. Gen. Virol. 84:17-28(2003).
RN   [3]
RP   ERRATUM OF PUBMED:12533697.
RA   Davison A.J., Dolan A., Akter P., Addison C., Dargan D.J., Alcendor D.J.,
RA   McGeoch D.J., Hayward G.S.;
RL   J. Gen. Virol. 84:1053-1053(2003).
RN   [4]
RP   SUBCELLULAR LOCATION, AND ISOFORM UL117.5.
RX   PubMed=18216115; DOI=10.1128/jvi.01964-07;
RA   Qian Z., Xuan B., Hong T.T., Yu D.;
RT   "The full-length protein encoded by human cytomegalovirus gene UL117 is
RT   required for the proper maturation of viral replication compartments.";
RL   J. Virol. 82:3452-3465(2008).
RN   [5]
RP   FUNCTION.
RX   PubMed=20333247; DOI=10.1371/journal.ppat.1000814;
RA   Qian Z., Leung-Pineda V., Xuan B., Piwnica-Worms H., Yu D.;
RT   "Human cytomegalovirus protein pUL117 targets the mini-chromosome
RT   maintenance complex and suppresses cellular DNA synthesis.";
RL   PLoS Pathog. 6:E1000814-E1000814(2010).
CC   -!- FUNCTION: Plays a role in the inhibition of host DNA replication in the
CC       infected cell. Targets the mini-chromosome maintenance (MCM) complex
CC       and blocks the accumulation of MCM proteins and their loading onto host
CC       chromatin. {ECO:0000269|PubMed:20333247}.
CC   -!- SUBCELLULAR LOCATION: [Isoform UL117]: Host nucleus
CC       {ECO:0000269|PubMed:18216115}. Note=The major fraction localizes to
CC       nuclear compartments. {ECO:0000269|PubMed:18216115}.
CC   -!- SUBCELLULAR LOCATION: [Isoform UL117.5]: Host nucleus
CC       {ECO:0000269|PubMed:18216115}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative initiation; Named isoforms=2;
CC       Name=UL117;
CC         IsoId=P16770-1; Sequence=Displayed;
CC       Name=UL117.5;
CC         IsoId=P16770-2; Sequence=VSP_044012;
CC   -!- SIMILARITY: Belongs to the herpesviridae U84 family. {ECO:0000305}.
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DR   EMBL; X17403; CAA35319.1; -; Genomic_DNA.
DR   EMBL; BK000394; DAA00107.1; -; Genomic_DNA.
DR   PIR; S09884; S09884.
DR   Proteomes; UP000008991; Genome.
DR   Proteomes; UP000008992; Genome.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   InterPro; IPR005028; Herpes_IE2_3.
DR   Pfam; PF03361; Herpes_IE2_3; 1.
PE   3: Inferred from homology;
KW   Alternative initiation; Host nucleus; Reference proteome.
FT   CHAIN           1..424
FT                   /note="Protein UL117"
FT                   /id="PRO_0000116332"
FT   REGION          57..82
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         1..130
FT                   /note="Missing (in isoform UL117.5)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_044012"
SQ   SEQUENCE   424 AA;  45463 MW;  CCC1460185B431BD CRC64;
     MVMFSQDHVQ IVYGSTRICK SLAPANKRKT HRTIVVAPRR GFLRIPPDGQ DVNHVKIVPT
     TSSSLAPPRD DERRPTPPLR PPLTVYPYGT SLIRRSARDA KLRSKLIVFH ITRPALGQHP
     QNPGISGPAA MDHSEFLTSF RREVDRQTVL TAESAPATAE VCLGDALPGG VMGGGGLPAG
     VGSASAAVAA AAAAVAGVPV AANPVMPATA TVTTPPMIDL TSHHRPLTLF TPASAAAAPA
     VATNGGNATY ILPADCRYAP LFASKYKYVF EEVSRLMRLH DSTAVQLQIS ASCGNAFQAL
     KSALLKLHNV TVLAGQQLIT QTMPHTPQAV ATFKFFHQDP NRVLDCIRPV VPRSTSYHET
     GVYQMWVSGA TKKDLFDAVT LCASIVEKQP DVFNINVSLL TYPSIAAPHL PLYNEFTSFR
     LPTS