ID   UL117_HCMVM             Reviewed;         425 AA.
AC   F5HFA5;
DT   11-JUL-2012, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   23-FEB-2022, entry version 23.
DE   RecName: Full=Protein UL117;
DE            Short=pUL117;
GN   Name=UL117;
OS   Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Cytomegalovirus.
OX   NCBI_TaxID=295027;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15105547; DOI=10.1099/vir.0.79888-0;
RA   Dolan A., Cunningham C., Hector R.D., Hassan-Walker A.F., Lee L.,
RA   Addison C., Dargan D.J., McGeoch D.J., Gatherer D., Emery V.C.,
RA   Griffiths P.D., Sinzger C., McSharry B.P., Wilkinson G.W.G., Davison A.J.;
RT   "Genetic content of wild-type human cytomegalovirus.";
RL   J. Gen. Virol. 85:1301-1312(2004).
CC   -!- FUNCTION: Plays a role in the inhibition of host DNA replication in the
CC       infected cell. Targets the mini-chromosome maintenance (MCM) complex
CC       and blocks the accumulation of MCM proteins and their loading onto host
CC       chromatin (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: [Isoform UL117]: Host nucleus {ECO:0000250}.
CC       Note=The major fraction localizes to nuclear compartments.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: [Isoform UL117.5]: Host nucleus {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative initiation; Named isoforms=2;
CC       Name=UL117;
CC         IsoId=F5HFA5-1; Sequence=Displayed;
CC       Name=UL117.5;
CC         IsoId=F5HFA5-2; Sequence=VSP_044020;
CC   -!- SIMILARITY: Belongs to the herpesviridae U84 family. {ECO:0000305}.
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DR   EMBL; AY446894; AAR31661.1; -; Genomic_DNA.
DR   RefSeq; YP_081557.1; NC_006273.2.
DR   PRIDE; F5HFA5; -.
DR   DNASU; 3077511; -.
DR   GeneID; 3077511; -.
DR   KEGG; vg:3077511; -.
DR   Reactome; R-HSA-9610379; HCMV Late Events.
DR   Proteomes; UP000000938; Genome.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   InterPro; IPR005028; Herpes_IE2_3.
DR   Pfam; PF03361; Herpes_IE2_3; 1.
PE   3: Inferred from homology;
KW   Alternative initiation; Host nucleus; Reference proteome.
FT   CHAIN           1..425
FT                   /note="Protein UL117"
FT                   /id="PRO_0000418276"
FT   REGION          59..83
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         1..131
FT                   /note="Missing (in isoform UL117.5)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_044020"
SQ   SEQUENCE   425 AA;  45592 MW;  3E235734E02C9401 CRC64;
     MVMFSQDHVQ IVYGSTRICK SLAPANKRKT HRTIVVAPRR GFLRIPPDGQ DVNHVKIVPT
     TTSSSLAPPR DDERRPTPPL RPPLTVYPYG TSLIRRSARD AKLRSKLIVF HITRPALGQH
     PQNPGISGPA AMDHSEFLTS FRREVDRQTV LTAESAPATV EVCLGDALPG GVMGGGGLPA
     GVGSASAAVA AAAAAVAGVP VAANPVMPAT ATVTTPPMID LTSHHRPLTL FTPASAAAAP
     AVATNGGNAT YILPADCRYA PLFASKYKYV FEEVSRLMRL HDSTAVQLQI SASCGNAFQA
     LKSALLKLHN VTVLAGQQLI TQTMPHTPQA VATFKFFHQD PNRVLDCIRP VVPRSTSYHE
     TGVYQMWVSG ATKKDLFDAV TLCASIVEKQ PDVFNINVSL LTYPSIAAPH LPLYNEFTSF
     RLPTS