UL119_HCMVA
ID UL119_HCMVA Reviewed; 345 AA.
AC P16739; P16834; Q8QP99;
DT 01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT 15-FEB-2005, sequence version 2.
DT 03-AUG-2022, entry version 78.
DE RecName: Full=Viral Fc-gamma receptor-like protein UL119;
DE AltName: Full=gp68;
DE Flags: Precursor;
GN Name=UL119/UL118;
OS Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5).
OC Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC Herpesvirales; Herpesviridae; Betaherpesvirinae; Cytomegalovirus.
OX NCBI_TaxID=10360;
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=2161319; DOI=10.1007/978-3-642-74980-3_6;
RA Chee M.S., Bankier A.T., Beck S., Bohni R., Brown C.M., Cerny R.,
RA Horsnell T., Hutchison C.A. III, Kouzarides T., Martignetti J.A.,
RA Preddie E., Satchwell S.C., Tomlinson P., Weston K.M., Barrell B.G.;
RT "Analysis of the protein-coding content of the sequence of human
RT cytomegalovirus strain AD169.";
RL Curr. Top. Microbiol. Immunol. 154:125-169(1990).
RN [2]
RP NUCLEOTIDE SEQUENCE, AND IDENTIFICATION.
RX PubMed=12163579; DOI=10.1128/jvi.76.17.8596-8608.2002;
RA Atalay R., Zimmermann A., Wagner M., Borst E., Benz C., Messerle M.,
RA Hengel H.;
RT "Identification and expression of human cytomegalovirus transcription units
RT coding for two distinct Fcgamma receptor homologs.";
RL J. Virol. 76:8596-8608(2002).
RN [3]
RP GENOME REANNOTATION.
RX PubMed=12533697; DOI=10.1099/vir.0.18606-0;
RA Davison A.J., Dolan A., Akter P., Addison C., Dargan D.J., Alcendor D.J.,
RA McGeoch D.J., Hayward G.S.;
RT "The human cytomegalovirus genome revisited: comparison with the chimpanzee
RT cytomegalovirus genome.";
RL J. Gen. Virol. 84:17-28(2003).
RN [4]
RP ERRATUM OF PUBMED:12533697.
RA Davison A.J., Dolan A., Akter P., Addison C., Dargan D.J., Alcendor D.J.,
RA McGeoch D.J., Hayward G.S.;
RL J. Gen. Virol. 84:1053-1053(2003).
RN [5]
RP IDENTIFICATION.
RX PubMed=15452216; DOI=10.1128/jvi.78.20.10960-10966.2004;
RA Varnum S.M., Streblow D.N., Monroe M.E., Smith P., Auberry K.J.,
RA Pasa-Tolic L., Wang D., Camp D.G. II, Rodland K., Wiley S., Britt W.,
RA Shenk T., Smith R.D., Nelson J.A.;
RT "Identification of proteins in human cytomegalovirus (HCMV) particles: the
RT HCMV proteome.";
RL J. Virol. 78:10960-10966(2004).
RN [6]
RP ERRATUM OF PUBMED:15452216.
RA Varnum S.M., Streblow D.N., Monroe M.E., Smith P., Auberry K.J.,
RA Pasa-Tolic L., Wang D., Camp D.G. II, Rodland K., Wiley S., Britt W.,
RA Shenk T., Smith R.D., Nelson J.A.;
RL J. Virol. 78:13395-13395(2004).
RN [7]
RP FUNCTION.
RX PubMed=18216124; DOI=10.1128/jvi.01476-07;
RA Sprague E.R., Reinhard H., Cheung E.J., Farley A.H., Trujillo R.D.,
RA Hengel H., Bjorkman P.J.;
RT "The human cytomegalovirus Fc receptor gp68 binds the Fc CH2-CH3 interface
RT of immunoglobulin G.";
RL J. Virol. 82:3490-3499(2008).
CC -!- FUNCTION: Serves as a receptor for the Fc part of human IgG. May thus
CC be involved in interfering with host Ig-mediated immune responses.
CC {ECO:0000269|PubMed:18216124}.
CC -!- SUBCELLULAR LOCATION: Virion membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAA35320.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=CAA35321.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; X17403; CAA35320.1; ALT_SEQ; Genomic_DNA.
DR EMBL; X17403; CAA35321.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AY065993; AAL49993.1; -; mRNA.
DR EMBL; BK000394; DAA00108.1; -; Genomic_DNA.
DR PIR; S09885; S09885.
DR PIR; S09886; S09886.
DR Proteomes; UP000008991; Genome.
DR Proteomes; UP000008992; Genome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0075528; P:modulation by virus of host immune response; IEA:UniProtKB-KW.
PE 2: Evidence at transcript level;
KW Glycoprotein; Host-virus interaction; Immunoglobulin domain; Membrane;
KW Modulation of host immunity by viral IgG Fc receptor-like protein;
KW Reference proteome; Signal; Transmembrane; Transmembrane helix;
KW Viral immunoevasion; Virion.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT CHAIN 24..345
FT /note="Viral Fc-gamma receptor-like protein UL119"
FT /id="PRO_0000037457"
FT TOPO_DOM 24..294
FT /note="Virion surface"
FT /evidence="ECO:0000255"
FT TRANSMEM 295..317
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 318..345
FT /note="Intravirion"
FT /evidence="ECO:0000255"
FT DOMAIN 91..190
FT /note="Ig-like V-type"
FT REGION 23..42
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 34
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT CARBOHYD 48
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT CARBOHYD 95
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT CARBOHYD 104
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT CARBOHYD 148
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT CARBOHYD 179
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT CARBOHYD 198
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT CARBOHYD 217
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT CARBOHYD 225
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT CARBOHYD 241
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT CARBOHYD 244
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT CARBOHYD 260
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
SQ SEQUENCE 345 AA; 38709 MW; 1366F5857E5DF650 CRC64;
MCSVLAIALV VALLGDMHPG VKSSTTSAVT SPSNTTVTST TSISTSNNVT SAVTTTVQTS
TSSASTSVIA TTQKEGHLYT VNCEASYSHD QVSLNATCKV ILLNNTKNPD ILSVTCYART
DCKGPFTQVG YLSAFPPDNE GKLHLSYNAT AQELLISGLR PQETTEYTCS FFSWGRHHNA
TWDLFTYPIY AVYGTRLNAT TMRVRVLLQE HEHCLLNGSS LYHPNSTVHL HQGNQLIPPW
NISNVTYNGQ RLREFVFYLN GTYTVVRLHV QIAGRSFTTT YVFIKSDPLF EDRLLAYGVL
AFLVFMVIIL LYVTYMLARR RDWSYKRLEE PVEEKKHPVP YFKQW
