ID   UL119_HCMVM             Reviewed;         345 AA.
AC   F5HC14;
DT   13-JUN-2012, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   03-AUG-2022, entry version 27.
DE   RecName: Full=Viral Fc-gamma receptor-like protein UL119;
DE   AltName: Full=gp68;
DE   Flags: Precursor;
GN   Name=UL119/UL118;
OS   Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Cytomegalovirus.
OX   NCBI_TaxID=295027;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15105547; DOI=10.1099/vir.0.79888-0;
RA   Dolan A., Cunningham C., Hector R.D., Hassan-Walker A.F., Lee L.,
RA   Addison C., Dargan D.J., McGeoch D.J., Gatherer D., Emery V.C.,
RA   Griffiths P.D., Sinzger C., McSharry B.P., Wilkinson G.W.G., Davison A.J.;
RT   "Genetic content of wild-type human cytomegalovirus.";
RL   J. Gen. Virol. 85:1301-1312(2004).
CC   -!- FUNCTION: Serves as a receptor for the Fc part of human IgG. May thus
CC       be involved in interfering with host Ig-mediated immune responses (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion membrane {ECO:0000305}; Single-pass type I
CC       membrane protein {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AY446894; AAR31662.1; -; Genomic_DNA.
DR   RefSeq; YP_081558.1; NC_006273.2.
DR   PRIDE; F5HC14; -.
DR   GeneID; 3077514; -.
DR   KEGG; vg:3077514; -.
DR   Reactome; R-HSA-9609690; HCMV Early Events.
DR   Proteomes; UP000000938; Genome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0075528; P:modulation by virus of host immune response; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   Glycoprotein; Host-virus interaction; Immunoglobulin domain; Membrane;
KW   Modulation of host immunity by viral IgG Fc receptor-like protein;
KW   Reference proteome; Signal; Transmembrane; Transmembrane helix;
KW   Viral immunoevasion; Virion.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   CHAIN           24..345
FT                   /note="Viral Fc-gamma receptor-like protein UL119"
FT                   /id="PRO_0000417836"
FT   TOPO_DOM        24..293
FT                   /note="Virion surface"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        294..314
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        315..345
FT                   /note="Intravirion"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          91..190
FT                   /note="Ig-like V-type"
FT   REGION          23..43
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        34
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        48
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        95
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        104
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        148
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        179
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        198
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        217
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        225
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        241
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        244
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        260
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   345 AA;  38711 MW;  D776336BD4549325 CRC64;
     MCSVLAIALV VALLGDMHPG VKSSTTSAVT SPSNTTVTST TSISTSNNVS SAVTTTVQTS
     TSSASTSVIA TTQKEGHLYT VNCEASYSYD QVSLNATCKV ILLNNTKNPD ILSVTCYART
     DCKGPFTQVG YLSAFPSNDK GKLHLSYNAT AQELLISGLR PQETTEYTCS FFSWGRHHNA
     TWDLFTYPIY AVYGTRLNAT TMRVRVLLQE HEHCLLNGSS LYHPNSTVHL HQGDQLIPPW
     NISNVTYNGQ RLREFVFYLN GTYTVVRLHV QIAGRSFTTT YVFIKSDPLF EDRLLAYGVL
     AFLVFMVIIL LYVTYMLARR RDWSYKRLEE PVEEKKHPVP YFKQW