ID   UL121_HCMVM             Reviewed;         180 AA.
AC   F5HD27;
DT   21-MAR-2012, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   23-FEB-2022, entry version 24.
DE   RecName: Full=Membrane protein UL121;
DE   Flags: Precursor;
GN   Name=UL121;
OS   Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Cytomegalovirus.
OX   NCBI_TaxID=295027;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15105547; DOI=10.1099/vir.0.79888-0;
RA   Dolan A., Cunningham C., Hector R.D., Hassan-Walker A.F., Lee L.,
RA   Addison C., Dargan D.J., McGeoch D.J., Gatherer D., Emery V.C.,
RA   Griffiths P.D., Sinzger C., McSharry B.P., Wilkinson G.W.G., Davison A.J.;
RT   "Genetic content of wild-type human cytomegalovirus.";
RL   J. Gen. Virol. 85:1301-1312(2004).
CC   -!- SUBCELLULAR LOCATION: Host membrane {ECO:0000305}; Single-pass type I
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the HHV-5 UL121 protein family. {ECO:0000305}.
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DR   EMBL; AY446894; AAR31664.1; -; Genomic_DNA.
DR   RefSeq; YP_081560.1; NC_006273.2.
DR   PRIDE; F5HD27; -.
DR   GeneID; 3077529; -.
DR   KEGG; vg:3077529; -.
DR   Reactome; R-HSA-9610379; HCMV Late Events.
DR   Proteomes; UP000000938; Genome.
DR   GO; GO:0033644; C:host cell membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR022545; HHV_UL121.
DR   Pfam; PF10838; DUF2677; 1.
PE   3: Inferred from homology;
KW   Host membrane; Membrane; Reference proteome; Signal; Transmembrane;
KW   Transmembrane helix.
FT   SIGNAL          1..27
FT                   /evidence="ECO:0000255"
FT   CHAIN           28..180
FT                   /note="Membrane protein UL121"
FT                   /id="PRO_0000416447"
FT   TRANSMEM        143..163
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   180 AA;  20253 MW;  F150E34237068A88 CRC64;
     MWGCGWSRIL VLLLLMCMAL MARGTYGAYI CSPNPGRLRI SCALSVLDQR LWWEIQYSSG
     RLTRVLVFHD EGEEGDDVHL TDTHHCTSCT HPYVISLVTP LTINATLRLL IRDGMYGRGE
     KELCIAHLPT LRDIRTCRVD ADLGLLYAVC LILSFSIVTA ALWKVDYDRS VAVVSKSYKS