ID   UL130_HCMVA             Reviewed;         214 AA.
AC   P16772; Q7M6S0;
DT   01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1990, sequence version 1.
DT   03-AUG-2022, entry version 56.
DE   RecName: Full=Uncharacterized protein UL130;
GN   Name=UL130;
OS   Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Cytomegalovirus.
OX   NCBI_TaxID=10360;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=2161319; DOI=10.1007/978-3-642-74980-3_6;
RA   Chee M.S., Bankier A.T., Beck S., Bohni R., Brown C.M., Cerny R.,
RA   Horsnell T., Hutchison C.A. III, Kouzarides T., Martignetti J.A.,
RA   Preddie E., Satchwell S.C., Tomlinson P., Weston K.M., Barrell B.G.;
RT   "Analysis of the protein-coding content of the sequence of human
RT   cytomegalovirus strain AD169.";
RL   Curr. Top. Microbiol. Immunol. 154:125-169(1990).
RN   [2]
RP   GENOME REANNOTATION.
RX   PubMed=12533697; DOI=10.1099/vir.0.18606-0;
RA   Davison A.J., Dolan A., Akter P., Addison C., Dargan D.J., Alcendor D.J.,
RA   McGeoch D.J., Hayward G.S.;
RT   "The human cytomegalovirus genome revisited: comparison with the chimpanzee
RT   cytomegalovirus genome.";
RL   J. Gen. Virol. 84:17-28(2003).
RN   [3]
RP   ERRATUM OF PUBMED:12533697.
RA   Davison A.J., Dolan A., Akter P., Addison C., Dargan D.J., Alcendor D.J.,
RA   McGeoch D.J., Hayward G.S.;
RL   J. Gen. Virol. 84:1053-1053(2003).
CC   -!- FUNCTION: Plays a role in viral entry into host cells. Forms a
CC       pentameric complex at the surface of the viral envelope together with
CC       gH, gL, UL130 and UL131. This complex is required for entry in
CC       epithelial, endothelial and myeloid host cells. Mechanistically,
CC       engages host receptor(s) including neurophilin 2/NRP2 to mediate
CC       infection. {ECO:0000250|UniProtKB:F5HCP3}.
CC   -!- SUBUNIT: Forms the envelope pentamer complex (PC) composed of gH, gL,
CC       UL128, UL130, and UL131A. The pentamer interacts with host NRP2.
CC       {ECO:0000250|UniProtKB:F5HCP3}.
CC   -!- SUBCELLULAR LOCATION: Virion membrane {ECO:0000250|UniProtKB:F5HCP3}.
CC       Note=Found as a pentameric complex at the surface of virion envelope.
CC       {ECO:0000250|UniProtKB:F5HCP3}.
CC   -!- SIMILARITY: Belongs to the HHV-5 UL130 protein family. {ECO:0000305}.
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DR   EMBL; X17403; CAA35332.1; -; Genomic_DNA.
DR   EMBL; BK000394; DAA00116.1; -; Genomic_DNA.
DR   PIR; S09896; S09896.
DR   PDB; 7KBB; EM; 4.02 A; D=26-214.
DR   PDB; 7M22; EM; 3.65 A; D=26-214.
DR   PDB; 7M30; EM; 3.81 A; D=26-214.
DR   PDBsum; 7KBB; -.
DR   PDBsum; 7M22; -.
DR   PDBsum; 7M30; -.
DR   SMR; P16772; -.
DR   Proteomes; UP000008991; Genome.
DR   Proteomes; UP000008992; Genome.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0098670; P:entry receptor-mediated virion attachment to host cell; IEA:UniProtKB-KW.
DR   GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR   InterPro; IPR021038; Herpes_UL130_cytomegalovirus.
DR   Pfam; PF11668; Gp_UL130; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Host-virus interaction; Membrane; Reference proteome;
KW   Viral attachment to host cell; Viral attachment to host entry receptor;
KW   Virion; Virus entry into host cell.
FT   CHAIN           1..214
FT                   /note="Uncharacterized protein UL130"
FT                   /id="PRO_0000115365"
SQ   SEQUENCE   214 AA;  24652 MW;  B60FE62EC91F0CF7 CRC64;
     MLRLLLRHHF HCLLLCAVWA TPCLASPWST LTANQNPSPP WSKLTYSKPH DAATFYCPFL
     YPSPPRSPLQ FSGFQQVSTG PECRNETLYL LYNREGQTLV ERSSTWVKKV IWYLSGRNQT
     ILQRMPQTAS KPSDGNVQIS VEDAKIFGAH MVPKQTKLLR FVVNDGTRYQ MCVMKLESWA
     HVFRDYSVSF QVRLTFTEAN NQTYTFCTHP NLIV