ID   UL133_HCMVM             Reviewed;         257 AA.
AC   Q6SW10; D2K3U1;
DT   11-JUL-2012, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   23-FEB-2022, entry version 43.
DE   RecName: Full=Protein UL133;
GN   Name=UL133;
OS   Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Cytomegalovirus.
OX   NCBI_TaxID=295027;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15105547; DOI=10.1099/vir.0.79888-0;
RA   Dolan A., Cunningham C., Hector R.D., Hassan-Walker A.F., Lee L.,
RA   Addison C., Dargan D.J., McGeoch D.J., Gatherer D., Emery V.C.,
RA   Griffiths P.D., Sinzger C., McSharry B.P., Wilkinson G.W.G., Davison A.J.;
RT   "Genetic content of wild-type human cytomegalovirus.";
RL   J. Gen. Virol. 85:1301-1312(2004).
RN   [2]
RP   SUBCELLULAR LOCATION.
RC   STRAIN=FIX;
RX   PubMed=22241980; DOI=10.1371/journal.ppat.1002444;
RA   Umashankar M., Petrucelli A., Cicchini L., Caposio P., Kreklywich C.N.,
RA   Rak M., Bughio F., Goldman D.C., Hamlin K.L., Nelson J.A., Fleming W.H.,
RA   Streblow D.N., Goodrum F.;
RT   "A novel human cytomegalovirus locus modulates cell type-specific outcomes
RT   of infection.";
RL   PLoS Pathog. 7:E1002444-E1002444(2011).
CC   -!- SUBCELLULAR LOCATION: Host Golgi apparatus membrane
CC       {ECO:0000269|PubMed:22241980}; Multi-pass membrane protein
CC       {ECO:0000269|PubMed:22241980}.
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DR   EMBL; AY446894; AAR31685.1; -; Genomic_DNA.
DR   RefSeq; YP_081581.1; NC_006273.2.
DR   SMR; Q6SW10; -.
DR   PRIDE; Q6SW10; -.
DR   DNASU; 3077577; -.
DR   GeneID; 3077577; -.
DR   KEGG; vg:3077577; -.
DR   Reactome; R-HSA-9609690; HCMV Early Events.
DR   Proteomes; UP000000938; Genome.
DR   GO; GO:0044178; C:host cell Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
PE   4: Predicted;
KW   Host Golgi apparatus; Host membrane; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..257
FT                   /note="Protein UL133"
FT                   /id="PRO_0000418328"
FT   TRANSMEM        14..34
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        45..65
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          149..232
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        159..176
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        209..228
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   257 AA;  27582 MW;  556DE0EE9AC86F7A CRC64;
     MGCDVHDPSW QCQWGVPTII VAWITCAALG IWCLAGSSAD VSSGPGIAAV VGCSVFMIFL
     CAYLIRYREF FKDSVIDLLT CRWVRYCSCS CKCSCKCISG PCSRCCSACY KETMIYDMVQ
     YGHRRRPGHG DDPDRVICEI VESPPVSAPT VFVPPPSEES HQPVIPPQPP TPTSEPKPKK
     GRAKDKPKGR PKNKPPCEPT VSSQPPSQPT AMPGGPPDAS PPAMPQMPPG VAEAVQAAVQ
     AAMAAALQQQ QQHQTGT