ID   UL135_HCMVM             Reviewed;         308 AA.
AC   F5HAQ7;
DT   18-APR-2012, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   23-FEB-2022, entry version 24.
DE   RecName: Full=Protein UL135;
DE   Flags: Precursor;
GN   Name=UL135;
OS   Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Cytomegalovirus.
OX   NCBI_TaxID=295027;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15105547; DOI=10.1099/vir.0.79888-0;
RA   Dolan A., Cunningham C., Hector R.D., Hassan-Walker A.F., Lee L.,
RA   Addison C., Dargan D.J., McGeoch D.J., Gatherer D., Emery V.C.,
RA   Griffiths P.D., Sinzger C., McSharry B.P., Wilkinson G.W.G., Davison A.J.;
RT   "Genetic content of wild-type human cytomegalovirus.";
RL   J. Gen. Virol. 85:1301-1312(2004).
RN   [2]
RP   FUNCTION, SUBCELLULAR LOCATION, AND INTERACTION WITH HOST ABI1; ABI2; NAP1;
RP   WASF2 AND TLN1.
RX   PubMed=25121749; DOI=10.1016/j.chom.2014.07.005;
RA   Stanton R.J., Prod'homme V., Purbhoo M.A., Moore M., Aicheler R.J.,
RA   Heinzmann M., Bailer S.M., Haas J., Antrobus R., Weekes M.P., Lehner P.J.,
RA   Vojtesek B., Miners K.L., Man S., Wilkie G.S., Davison A.J., Wang E.C.,
RA   Tomasec P., Wilkinson G.W.;
RT   "HCMV pUL135 remodels the actin cytoskeleton to impair immune recognition
RT   of infected cells.";
RL   Cell Host Microbe 16:201-214(2014).
CC   -!- FUNCTION: Remodels the host actin cytoskeleton in order to impair
CC       immune recognition of infected cells. Mechanistically, interacts with
CC       members of the host WAVE2 complex and redirects the complex to the
CC       plasma membrane. In turn, the efficiency of immune synapse formation is
CC       greatly reduced. {ECO:0000269|PubMed:25121749}.
CC   -!- SUBUNIT: Interacts with host components of the WAVE2 complex ABI1, NAP1
CC       and WAVE2. Interacts also with host ABI2 and TLN1.
CC       {ECO:0000269|PubMed:25121749}.
CC   -!- SUBCELLULAR LOCATION: Host cell membrane {ECO:0000269|PubMed:25121749}.
CC       Host Golgi apparatus {ECO:0000269|PubMed:25121749}.
CC   -!- SIMILARITY: Belongs to the HCMV UL135 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AY446894; AAR31684.1; -; Genomic_DNA.
DR   RefSeq; YP_081580.1; NC_006273.2.
DR   BioGRID; 1678011; 21.
DR   PRIDE; F5HAQ7; -.
DR   DNASU; 3077458; -.
DR   GeneID; 3077458; -.
DR   KEGG; vg:3077458; -.
DR   Proteomes; UP000000938; Genome.
DR   GO; GO:0044177; C:host cell Golgi apparatus; IEA:UniProtKB-SubCell.
DR   GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0039671; P:evasion by virus of host natural killer cell activity; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Host cell membrane; Host Golgi apparatus; Host membrane;
KW   Host-virus interaction; Membrane;
KW   Modulation of host NK-cell activity by virus; Reference proteome; Signal;
KW   Viral immunoevasion.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..308
FT                   /note="Protein UL135"
FT                   /id="PRO_0000416731"
FT   REGION          105..274
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        119..150
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        153..176
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        184..238
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   308 AA;  33281 MW;  B94B2285BBB9752E CRC64;
     MVWLWLGVGL LGGTGLASLV LAISLFTQRR GRKRSDETSS RGRLPGAASD KRGACACCYR
     IPKEDVVEPL DLELGLMRVA THPPTPQVPR CTSLYIGEDG LPIDKPEFPP ARFEIPDVST
     PGTPTSIGRS PSHCSSSSSL SSSASVDTVL HQPPPSWKPP PPPGRKKRPP TPPVRAPTTR
     LSSHRPPTPI PAPRKNLSTP PTKKTPPPTK PKPVGWTPPV TPRPFPKTPT PQKPPRNPRL
     PRTVGLENLS KVGLSCPCPR PRTPTEPTTL PIVSVSELAP PPRWSDIEEL LEKAVQSVMK
     DAESMQMT