ID   UL135_HCMVT             Reviewed;         308 AA.
AC   Q6SWM9;
DT   18-APR-2012, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 34.
DE   RecName: Full=Protein UL135;
DE   Flags: Precursor;
GN   Name=UL135;
OS   Human cytomegalovirus (strain Towne) (HHV-5) (Human herpesvirus 5).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Cytomegalovirus.
OX   NCBI_TaxID=10363;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=19553388; DOI=10.1099/vir.0.013250-0;
RA   Bradley A.J., Lurain N.S., Ghazal P., Trivedi U., Cunningham C.,
RA   Baluchova K., Gatherer D., Wilkinson G.W., Dargan D.J., Davison A.J.;
RT   "High-throughput sequence analysis of variants of human cytomegalovirus
RT   strains Towne and AD169.";
RL   J. Gen. Virol. 90:2375-2380(2009).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15105547; DOI=10.1099/vir.0.79888-0;
RA   Dolan A., Cunningham C., Hector R.D., Hassan-Walker A.F., Lee L.,
RA   Addison C., Dargan D.J., McGeoch D.J., Gatherer D., Emery V.C.,
RA   Griffiths P.D., Sinzger C., McSharry B.P., Wilkinson G.W.G., Davison A.J.;
RT   "Genetic content of wild-type human cytomegalovirus.";
RL   J. Gen. Virol. 85:1301-1312(2004).
CC   -!- FUNCTION: Remodels the host actin cytoskeleton in order to impair
CC       immune recognition of infected cells. Mechanistically, interacts with
CC       members of the host WAVE2 complex and redirects the complex to the
CC       plasma membrane. In turn, the efficiency of immune synapse formation is
CC       greatly reduced. {ECO:0000250|UniProtKB:F5HAQ7}.
CC   -!- SUBUNIT: Interacts with host components of the WAVE2 complex ABI1, NAP1
CC       and WAVE2. Interacts also with host ABI2 and TLN1.
CC       {ECO:0000250|UniProtKB:F5HAQ7}.
CC   -!- SUBCELLULAR LOCATION: Host cell membrane
CC       {ECO:0000250|UniProtKB:F5HAQ7}. Host Golgi apparatus
CC       {ECO:0000250|UniProtKB:F5HAQ7}.
CC   -!- SIMILARITY: Belongs to the HCMV UL135 family. {ECO:0000305}.
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DR   EMBL; FJ616285; AAR31467.1; -; Genomic_DNA.
DR   SMR; Q6SWM9; -.
DR   Proteomes; UP000006907; Genome.
DR   GO; GO:0044177; C:host cell Golgi apparatus; IEA:UniProtKB-SubCell.
DR   GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0039671; P:evasion by virus of host natural killer cell activity; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   Host cell membrane; Host Golgi apparatus; Host membrane;
KW   Host-virus interaction; Membrane;
KW   Modulation of host NK-cell activity by virus; Signal; Viral immunoevasion.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..308
FT                   /note="Protein UL135"
FT                   /id="PRO_0000416732"
FT   REGION          103..274
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        119..151
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        153..176
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        184..238
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   308 AA;  33410 MW;  7DF4FD79C0FB72C9 CRC64;
     MVWIWLGVGL LGGTGLASLV LAISLFTQRR GRKRSDETSS RGRLPAAASD KRGACACCYR
     NPKEDVVEPL DLELGLMRVA THPPTPQVPR CTSLYIGEDG LPIDKPEFPP ARFEIPDVST
     PGTPTSIDRS PSHCSSLSSL SSSTSVDTVL HQPPPSWKPP PPPGRKKRPP TPPVRAPTTR
     LSSHRPPTPI PAPRKNLSTP PTKKTPPPTK PKPVGWTPPV TPRPFPKTPT PQKPPRNPRL
     PRTVGLENLS KVGLSCPCPR PRTPTEPTTL PIVSVSELAP PPRWSDIEEL LEQAVQSVMK
     DAESMQMT