ID   UL138_HCMVM             Reviewed;         169 AA.
AC   F5HGQ8;
DT   11-JUL-2012, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   23-FEB-2022, entry version 30.
DE   RecName: Full=Protein UL138;
GN   Name=UL138;
OS   Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Cytomegalovirus.
OX   NCBI_TaxID=295027;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15105547; DOI=10.1099/vir.0.79888-0;
RA   Dolan A., Cunningham C., Hector R.D., Hassan-Walker A.F., Lee L.,
RA   Addison C., Dargan D.J., McGeoch D.J., Gatherer D., Emery V.C.,
RA   Griffiths P.D., Sinzger C., McSharry B.P., Wilkinson G.W.G., Davison A.J.;
RT   "Genetic content of wild-type human cytomegalovirus.";
RL   J. Gen. Virol. 85:1301-1312(2004).
RN   [2]
RP   FUNCTION.
RX   PubMed=17440050; DOI=10.1182/blood-2007-01-070078;
RA   Goodrum F., Reeves M., Sinclair J., High K., Shenk T.;
RT   "Human cytomegalovirus sequences expressed in latently infected individuals
RT   promote a latent infection in vitro.";
RL   Blood 110:937-945(2007).
RN   [3]
RP   SUBCELLULAR LOCATION.
RC   STRAIN=FIXwt;
RX   PubMed=19297488; DOI=10.1128/jvi.01989-08;
RA   Petrucelli A., Rak M., Grainger L., Goodrum F.;
RT   "Characterization of a novel Golgi apparatus-localized latency determinant
RT   encoded by human cytomegalovirus.";
RL   J. Virol. 83:5615-5629(2009).
RN   [4]
RP   FUNCTION.
RX   PubMed=21880774; DOI=10.1128/jvi.05028-11;
RA   Montag C., Wagner J.A., Gruska I., Vetter B., Wiebusch L., Hagemeier C.;
RT   "The latency-associated UL138 gene product of human cytomegalovirus
RT   sensitizes cells to tumor necrosis factor alpha (TNF-alpha) signaling by
RT   upregulating TNF-alpha receptor 1 cell surface expression.";
RL   J. Virol. 85:11409-11421(2011).
RN   [5]
RP   FUNCTION, AND INTERACTION WITH HOST TNFR1.
RC   STRAIN=Toledo;
RX   PubMed=21976655; DOI=10.1128/jvi.06005-11;
RA   Le V.T., Trilling M., Hengel H.;
RT   "The cytomegaloviral protein pUL138 acts as potentiator of tumor necrosis
RT   factor (TNF) receptor 1 surface density to enhance ULb'-encoded modulation
RT   of TNF-alpha signaling.";
RL   J. Virol. 85:13260-13270(2011).
CC   -!- FUNCTION: Plays a role in the maintenance of a latent infection in low-
CC       passage strains. Additionally, sensitizes infected cells to tumor
CC       necrosis factor alpha (TNF-alpha) signaling. Increases host TNFR1
CC       stability and cell surface expression thus enhancing its signaling
CC       responses, leading to TNFR1 hyper-responsiveness. By up-regulating
CC       TNFR1 surface availability, UL138 may also promote HCMV reactivation.
CC       {ECO:0000269|PubMed:17440050, ECO:0000269|PubMed:21880774,
CC       ECO:0000269|PubMed:21976655}.
CC   -!- SUBUNIT: Interacts with host TNFR1. {ECO:0000269|PubMed:21976655}.
CC   -!- SUBCELLULAR LOCATION: Host Golgi apparatus membrane
CC       {ECO:0000269|PubMed:19297488}.
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DR   EMBL; AY446894; AAR31682.1; -; Genomic_DNA.
DR   RefSeq; YP_081578.1; NC_006273.2.
DR   SMR; F5HGQ8; -.
DR   PRIDE; F5HGQ8; -.
DR   DNASU; 3077420; -.
DR   GeneID; 3077420; -.
DR   KEGG; vg:3077420; -.
DR   Reactome; R-HSA-9609690; HCMV Early Events.
DR   Proteomes; UP000000938; Genome.
DR   GO; GO:0044178; C:host cell Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Host Golgi apparatus; Host membrane; Host-virus interaction; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..169
FT                   /note="Protein UL138"
FT                   /id="PRO_0000418301"
FT   TRANSMEM        8..28
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          109..133
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        109..126
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   169 AA;  19309 MW;  5D6A82346DDE357A CRC64;
     MDDLPLNVGL PIIGVMLVLI VAILCYLAYH WHDTFKLVRM FLSYRWLIRC CELYGEYERR
     FADLSSLGLG AVRRESDRRY RFSERPDEIL VRWEEVSSQC SYASSRITDR RAGSSSSSSV
     HVANQRNSVP PPDMAVTAPL TDVDLLKPVT GSATQFTTVA MVHYHQEYT