ID   UL13_HCMVA              Reviewed;         473 AA.
AC   P16755; Q7M6S1;
DT   01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1990, sequence version 1.
DT   03-AUG-2022, entry version 51.
DE   RecName: Full=Uncharacterized protein UL13;
GN   Name=UL13;
OS   Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Cytomegalovirus.
OX   NCBI_TaxID=10360;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=2161319; DOI=10.1007/978-3-642-74980-3_6;
RA   Chee M.S., Bankier A.T., Beck S., Bohni R., Brown C.M., Cerny R.,
RA   Horsnell T., Hutchison C.A. III, Kouzarides T., Martignetti J.A.,
RA   Preddie E., Satchwell S.C., Tomlinson P., Weston K.M., Barrell B.G.;
RT   "Analysis of the protein-coding content of the sequence of human
RT   cytomegalovirus strain AD169.";
RL   Curr. Top. Microbiol. Immunol. 154:125-169(1990).
RN   [2]
RP   GENOME REANNOTATION.
RX   PubMed=12533697; DOI=10.1099/vir.0.18606-0;
RA   Davison A.J., Dolan A., Akter P., Addison C., Dargan D.J., Alcendor D.J.,
RA   McGeoch D.J., Hayward G.S.;
RT   "The human cytomegalovirus genome revisited: comparison with the chimpanzee
RT   cytomegalovirus genome.";
RL   J. Gen. Virol. 84:17-28(2003).
RN   [3]
RP   ERRATUM OF PUBMED:12533697.
RA   Davison A.J., Dolan A., Akter P., Addison C., Dargan D.J., Alcendor D.J.,
RA   McGeoch D.J., Hayward G.S.;
RL   J. Gen. Virol. 84:1053-1053(2003).
RN   [4]
RP   FUNCTION, SUBCELLULAR LOCATION, AND INTERACTION WITH HOST IMMT AND CHCHD3.
RX   PubMed=34344827; DOI=10.1073/pnas.2101675118;
RA   Betsinger C.N., Jankowski C.S.R., Hofstadter W.A., Federspiel J.D.,
RA   Otter C.J., Jean Beltran P.M., Cristea I.M.;
RT   "The human cytomegalovirus protein pUL13 targets mitochondrial cristae
RT   architecture to increase cellular respiration during infection.";
RL   Proc. Natl. Acad. Sci. U.S.A. 118:0-0(2021).
CC   -!- FUNCTION: Plays an essential role during infection by modulating
CC       mitochondrial ultrastructure and thereby increasing bioenergetic
CC       potential. Mechanistically, alters cristae architecture by interacting
CC       with components of the host mitochondrial contact site and cristae
CC       organizing system (MICOS) complex. {ECO:0000269|PubMed:34344827}.
CC   -!- SUBUNIT: Interacts with host MICOS complex subunits IMMT and CHCHD3.
CC       {ECO:0000269|PubMed:34344827}.
CC   -!- SUBCELLULAR LOCATION: Host mitochondrion {ECO:0000269|PubMed:34344827}.
CC   -!- SIMILARITY: Belongs to the HHV-5 UL13 protein family. {ECO:0000305}.
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DR   EMBL; X17403; CAA35445.1; -; Genomic_DNA.
DR   EMBL; BK000394; DAA00115.1; -; Genomic_DNA.
DR   PIR; S09775; S09775.
DR   Proteomes; UP000008991; Genome.
DR   Proteomes; UP000008992; Genome.
DR   GO; GO:0033650; C:host cell mitochondrion; IEA:UniProtKB-SubCell.
PE   1: Evidence at protein level;
KW   Host mitochondrion; Host-virus interaction; Reference proteome.
FT   CHAIN           1..473
FT                   /note="Uncharacterized protein UL13"
FT                   /id="PRO_0000115308"
FT   REGION          105..124
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          142..201
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          232..253
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          327..437
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        167..201
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        346..403
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   473 AA;  54613 MW;  378C32A16ED3F018 CRC64;
     MLWAHCGRFL RYHLLPLLLC RLPFLLLFQR PQWAHGLDIV EEDEWLREIQ GATYQLSIVR
     QAMQHAGFQV RAASVMTRRN AVDLDRPPLW SGSLPHLPVY DVRSPRPLRP PSSQHHAVSP
     ELPSRDGIRW QYQELQYLVE EQRRRNQSRN AIPRPSFPPP DPPSQPAEDA RDADAERTES
     PHSAESTVRH DASENAVRRR HERRRYNALT VRSRDSLLLT RIRFSNQRCF GRGRLRHPAG
     SGPNTGGPRP GGAGLRQLRQ QLTVRWQLFR LRCHGWTQQV SSQIRTRWEE SNVVSQTATR
     VRTWFVERTT FWRRTWVPRQ NPAAEAQELA VIPPAPTVLR QNEEPRQQLT GEETRNSTHT
     QREEVEDVSR EGAREGNDGS RASGNDERRN NAGRYDDDHE VQEPQVTYPA GQGELNRRSQ
     EENEEGGPCE SPPMTTNTLT VACPPREPPH RALFRLCLGL WVSSYLVRRP MTI