ID   UL13_HCMVM              Reviewed;         473 AA.
AC   Q6SWB8; D2K3I2;
DT   13-JUN-2012, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 47.
DE   RecName: Full=Uncharacterized protein UL13;
DE   Flags: Precursor;
GN   Name=UL13;
OS   Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Cytomegalovirus.
OX   NCBI_TaxID=295027;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15105547; DOI=10.1099/vir.0.79888-0;
RA   Dolan A., Cunningham C., Hector R.D., Hassan-Walker A.F., Lee L.,
RA   Addison C., Dargan D.J., McGeoch D.J., Gatherer D., Emery V.C.,
RA   Griffiths P.D., Sinzger C., McSharry B.P., Wilkinson G.W.G., Davison A.J.;
RT   "Genetic content of wild-type human cytomegalovirus.";
RL   J. Gen. Virol. 85:1301-1312(2004).
CC   -!- FUNCTION: Plays an essential role during infection by modulating
CC       mitochondrial ultrastructure and thereby increasing bioenergetic
CC       potential. Mechanistically, alters cristae architecture by interacting
CC       with components of the host mitochondrial contact site and cristae
CC       organizing system (MICOS) complex. {ECO:0000250|UniProtKB:P16755}.
CC   -!- SUBUNIT: Interacts with host MICOS complex subunits IMMT and CHCHD3.
CC       {ECO:0000250|UniProtKB:P16755}.
CC   -!- SUBCELLULAR LOCATION: Host mitochondrion
CC       {ECO:0000250|UniProtKB:P16755}.
CC   -!- SIMILARITY: Belongs to the HHV-5 UL13 protein family. {ECO:0000305}.
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DR   EMBL; AY446894; AAR31578.1; -; Genomic_DNA.
DR   RefSeq; YP_081472.1; NC_006273.2.
DR   PRIDE; Q6SWB8; -.
DR   DNASU; 3077428; -.
DR   GeneID; 3077428; -.
DR   KEGG; vg:3077428; -.
DR   Reactome; R-HSA-9609690; HCMV Early Events.
DR   Proteomes; UP000000938; Genome.
DR   GO; GO:0033650; C:host cell mitochondrion; IEA:UniProtKB-SubCell.
PE   3: Inferred from homology;
KW   Host mitochondrion; Host-virus interaction; Reference proteome; Signal.
FT   SIGNAL          1..35
FT                   /evidence="ECO:0000255"
FT   CHAIN           36..473
FT                   /note="Uncharacterized protein UL13"
FT                   /id="PRO_0000417837"
FT   REGION          142..201
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          232..254
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          331..437
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        167..184
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        346..403
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   473 AA;  54427 MW;  61A716C168B7B590 CRC64;
     MLWAHCGRFL RYHLLPLLLC RLPFLLFFQR PQWAHGLDIV EEDEWLREIQ GATYQLSIVR
     QAMQHAGFQV RAASVMTRRN AVDLDRPPLW SGSLPHLPVY DVRSPRPLRP PSSQHHAVSP
     ELPSRNGIRW QYQELQYLVE EQRRRNQSRN AIPRPSFPPP DPPSQPAEDA RDADAERAES
     PHTAESTVSH DASDNAVRRR HERRRYNALT VRSRDSLLLT RIRFSNQRCF GRGRLRHPAG
     SGPNTGGPRP GGAGLRQLRQ QLTVRWQLFR LRCHGWTQQV SSQIRTRWEE SNVVSQTATR
     VRTWFVQRTT LWRRTWVPGQ NPAAEAQELA IIPPAPTVLR QNEEPRQQLT GEETRNSTHT
     QREEVEDVSR EGAREGNDGS RASGNDERRN NAGRYDDDHE VQEPQVTYPA GQGELNRRSQ
     EENEEGGPCE SPPMTTNTLT VACPPREPPH RALFRLCLGL WVSSYLVRRP MTI