ID   UL142_HCMVM             Reviewed;         305 AA.
AC   F5HHH2;
DT   11-JUL-2012, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   02-JUN-2021, entry version 30.
DE   RecName: Full=Membrane glycoprotein UL142;
DE   Flags: Precursor;
GN   Name=UL142;
OS   Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Cytomegalovirus.
OX   NCBI_TaxID=295027;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15105547; DOI=10.1099/vir.0.79888-0;
RA   Dolan A., Cunningham C., Hector R.D., Hassan-Walker A.F., Lee L.,
RA   Addison C., Dargan D.J., McGeoch D.J., Gatherer D., Emery V.C.,
RA   Griffiths P.D., Sinzger C., McSharry B.P., Wilkinson G.W.G., Davison A.J.;
RT   "Genetic content of wild-type human cytomegalovirus.";
RL   J. Gen. Virol. 85:1301-1312(2004).
RN   [2]
RP   FUNCTION.
RX   PubMed=16301653; DOI=10.4049/jimmunol.175.11.7457;
RA   Wills M.R., Ashiru O., Reeves M.B., Okecha G., Trowsdale J., Tomasec P.,
RA   Wilkinson G.W., Sinclair J., Sissons J.G.;
RT   "Human cytomegalovirus encodes an MHC class I-like molecule (UL142) that
RT   functions to inhibit NK cell lysis.";
RL   J. Immunol. 175:7457-7465(2005).
RN   [3]
RP   FUNCTION, INTERACTION WITH HOST MICA, AND SUBCELLULAR LOCATION.
RX   PubMed=19793804; DOI=10.1128/jvi.01175-09;
RA   Ashiru O., Bennett N.J., Boyle L.H., Thomas M., Trowsdale J., Wills M.R.;
RT   "NKG2D ligand MICA is retained in the cis-Golgi apparatus by human
RT   cytomegalovirus protein UL142.";
RL   J. Virol. 83:12345-12354(2009).
RN   [4]
RP   FUNCTION, AND INTERACTION WITH HOST ULBP3.
RX   PubMed=20530255; DOI=10.4049/jimmunol.1000789;
RA   Bennett N.J., Ashiru O., Morgan F.J., Pang Y., Okecha G., Eagle R.A.,
RA   Trowsdale J., Sissons J.G., Wills M.R.;
RT   "Intracellular sequestration of the NKG2D ligand ULBP3 by human
RT   cytomegalovirus.";
RL   J. Immunol. 185:1093-1102(2010).
CC   -!- FUNCTION: Participates in the inhibition of the host immune response.
CC       Prevents host NK cell-mediated lysis of the infected cell by preventing
CC       the KLRK1 ligand 3/ULBP3 trafficking to the cell surface. Retains also
CC       another KLRK1 ligand, MHC class I-related chain A/MICA, in the Golgi
CC       apparatus to avoid its surface expression.
CC       {ECO:0000269|PubMed:16301653, ECO:0000269|PubMed:19793804,
CC       ECO:0000269|PubMed:20530255}.
CC   -!- SUBUNIT: Interacts with host MICA and ULBP3.
CC       {ECO:0000269|PubMed:19793804, ECO:0000269|PubMed:20530255}.
CC   -!- SUBCELLULAR LOCATION: Host endoplasmic reticulum membrane
CC       {ECO:0000269|PubMed:19793804}; Single-pass membrane protein
CC       {ECO:0000269|PubMed:19793804}. Host Golgi apparatus membrane
CC       {ECO:0000269|PubMed:19793804}; Single-pass membrane protein
CC       {ECO:0000269|PubMed:19793804}.
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DR   EMBL; AY446894; AAR31678.1; -; Genomic_DNA.
DR   RefSeq; YP_081574.1; NC_006273.2.
DR   PRIDE; F5HHH2; -.
DR   DNASU; 3077552; -.
DR   GeneID; 3077552; -.
DR   KEGG; vg:3077552; -.
DR   Proteomes; UP000000938; Genome.
DR   GO; GO:0044167; C:host cell endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0044178; C:host cell Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.500.10; -; 1.
DR   InterPro; IPR037055; MHC_I-like_Ag-recog_sf.
DR   InterPro; IPR011162; MHC_I/II-like_Ag-recog.
DR   SUPFAM; SSF54452; SSF54452; 1.
PE   1: Evidence at protein level;
KW   Host endoplasmic reticulum; Host Golgi apparatus; Host membrane; Membrane;
KW   Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..305
FT                   /note="Membrane glycoprotein UL142"
FT                   /id="PRO_0000418303"
FT   TOPO_DOM        20..270
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        271..288
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        289..305
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   305 AA;  34626 MW;  6E67EFD0E22B8F5A CRC64;
     MRIEWACWLF GYFVSSVGSE RSLSYRYHLE SNSSANVVCN GNISVFVNGT LGVRYNITVG
     ISSSLLIGHL TIQTLESWFT PWVQNKSYSK QPLSTTETLY NIDSENIHRV SQYFHTRWIK
     SLQENHTCDL TNSTPTYTYQ ANVNNTNYLT LTSSGWQDRL NYTAINSTHF NLTESNITSI
     HKYLNTTCIE RLRNYTLEPV YTTAVPQNVT PEHAITTLYT TPPNAITIKD TTQSHTVQTP
     SFNDTHNVTE HTLNISYVLS QKTNNTTSPW VYAIPMGATA TIGAGLYIGK HFTPVKFVYE
     VWRGQ