ID   UL144_HCMVM             Reviewed;         176 AA.
AC   F5HAM0;
DT   14-DEC-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   23-FEB-2022, entry version 31.
DE   RecName: Full=Membrane glycoprotein UL144;
DE   AltName: Full=TNF alpha-like receptor UL144;
DE   AltName: Full=UL144 protein;
DE   Flags: Precursor;
GN   Name=UL144; ORFNames=HHV5wtgp119;
OS   Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Cytomegalovirus.
OX   NCBI_TaxID=295027;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15105547; DOI=10.1099/vir.0.79888-0;
RA   Dolan A., Cunningham C., Hector R.D., Hassan-Walker A.F., Lee L.,
RA   Addison C., Dargan D.J., McGeoch D.J., Gatherer D., Emery V.C.,
RA   Griffiths P.D., Sinzger C., McSharry B.P., Wilkinson G.W.G., Davison A.J.;
RT   "Genetic content of wild-type human cytomegalovirus.";
RL   J. Gen. Virol. 85:1301-1312(2004).
CC   -!- FUNCTION: Activates NF-kappa-B in a tumor necrosis factor receptor
CC       (TNFR)-associated factor 6 (TRAF6)-dependent manner, causing the up-
CC       regulation of the chemokine CCL22. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with host TRIM23; this interaction causes auto-
CC       ubiquitination of TRAF6, leading to NF-kappaB activation.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
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DR   EMBL; AY446894; AAR31677.1; -; Genomic_DNA.
DR   RefSeq; YP_081573.1; NC_006273.2.
DR   SMR; F5HAM0; -.
DR   BioGRID; 1678024; 2.
DR   PRIDE; F5HAM0; -.
DR   DNASU; 3077471; -.
DR   GeneID; 3077471; -.
DR   KEGG; vg:3077471; -.
DR   Reactome; R-HSA-9610379; HCMV Late Events.
DR   Proteomes; UP000000938; Genome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0039652; P:induction by virus of host NF-kappaB cascade; IEA:UniProtKB-KW.
DR   InterPro; IPR001368; TNFR/NGFR_Cys_rich_reg.
DR   Pfam; PF00020; TNFR_c6; 1.
DR   SMART; SM00208; TNFR; 2.
DR   PROSITE; PS00652; TNFR_NGFR_1; 1.
DR   PROSITE; PS50050; TNFR_NGFR_2; 1.
PE   3: Inferred from homology;
KW   Activation of host NF-kappa-B by virus; Disulfide bond;
KW   Host-virus interaction; Membrane; Reference proteome; Repeat; Signal;
KW   Transmembrane; Transmembrane helix.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   CHAIN           21..176
FT                   /note="Membrane glycoprotein UL144"
FT                   /id="PRO_0000414120"
FT   TRANSMEM        134..154
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REPEAT          58..95
FT                   /note="TNFR-Cys"
FT   DISULFID        59..71
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT   DISULFID        74..87
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT   DISULFID        77..95
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
SQ   SEQUENCE   176 AA;  19629 MW;  B6726B043F38775B CRC64;
     MKPLVMLICF GVILLQLGVT KVCQHNEVQL GNECCPPCGL GQRVTKVCTE RTSVTCTPCP
     NGTYVSGLYN CTDCTQCNVT QVMIRNCTST NNTVCAPKNH TYFSTPGVQH HKQRQQNHTA
     HITVKQGKSG RHTLAWLSLF IFLVGIILLI LYLIAAYRSE RCQQCCSIGK IFYRTL