ID   UL147_HCMVM             Reviewed;         159 AA.
AC   F5HA06;
DT   21-MAR-2012, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   23-FEB-2022, entry version 28.
DE   RecName: Full=Putative viral CXC chemokine 2;
DE            Short=vCXCL2;
GN   Name=UL147;
OS   Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Cytomegalovirus.
OX   NCBI_TaxID=295027;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15105547; DOI=10.1099/vir.0.79888-0;
RA   Dolan A., Cunningham C., Hector R.D., Hassan-Walker A.F., Lee L.,
RA   Addison C., Dargan D.J., McGeoch D.J., Gatherer D., Emery V.C.,
RA   Griffiths P.D., Sinzger C., McSharry B.P., Wilkinson G.W.G., Davison A.J.;
RT   "Genetic content of wild-type human cytomegalovirus.";
RL   J. Gen. Virol. 85:1301-1312(2004).
CC   -!- SIMILARITY: Belongs to the intercrine alpha (chemokine CxC) family.
CC       {ECO:0000305}.
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DR   EMBL; AY446894; AAR31674.1; -; Genomic_DNA.
DR   RefSeq; YP_081570.1; NC_006273.2.
DR   SMR; F5HA06; -.
DR   PRIDE; F5HA06; -.
DR   DNASU; 3077419; -.
DR   GeneID; 3077419; -.
DR   KEGG; vg:3077419; -.
DR   Reactome; R-HSA-9610379; HCMV Late Events.
DR   Proteomes; UP000000938; Genome.
DR   GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR   GO; GO:0008009; F:chemokine activity; IEA:InterPro.
DR   GO; GO:0006952; P:defense response; IEA:InterPro.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   CDD; cd00273; Chemokine_CXC; 1.
DR   InterPro; IPR001811; Chemokine_IL8-like_dom.
DR   InterPro; IPR033899; CXC_Chemokine_domain.
DR   InterPro; IPR036048; Interleukin_8-like_sf.
DR   Pfam; PF00048; IL8; 1.
DR   SMART; SM00199; SCY; 1.
DR   SUPFAM; SSF54117; SSF54117; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; Reference proteome.
FT   CHAIN           1..159
FT                   /note="Putative viral CXC chemokine 2"
FT                   /id="PRO_0000416443"
FT   DISULFID        50..77
FT                   /evidence="ECO:0000250"
FT   DISULFID        52..93
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   159 AA;  18718 MW;  A88906C486B1C542 CRC64;
     MLLTWLHHPI LNSRIKLLSV RYLSLTAYML LAICPIAVRL LELEDYDKRC RCNNQILLNT
     LPVGTELLKP IAASESCNRQ EVLAILKDKG TKCLNPNAQA VRRHINRLFF RLVLDEEQRI
     YDVVSTNIEF GAWPVPTAYK AFLWKYAKKL NYHYFRLRW