ID   UL148_HCMVM             Reviewed;         316 AA.
AC   F5H8Q3;
DT   11-JUL-2012, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   03-AUG-2022, entry version 25.
DE   RecName: Full=Membrane protein UL148;
DE   Flags: Precursor;
GN   Name=UL148;
OS   Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Cytomegalovirus.
OX   NCBI_TaxID=295027;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15105547; DOI=10.1099/vir.0.79888-0;
RA   Dolan A., Cunningham C., Hector R.D., Hassan-Walker A.F., Lee L.,
RA   Addison C., Dargan D.J., McGeoch D.J., Gatherer D., Emery V.C.,
RA   Griffiths P.D., Sinzger C., McSharry B.P., Wilkinson G.W.G., Davison A.J.;
RT   "Genetic content of wild-type human cytomegalovirus.";
RL   J. Gen. Virol. 85:1301-1312(2004).
CC   -!- FUNCTION: Chaperone protein that plays an important role in HCMV
CC       tropism. Cooperates with UL116 to regulate the abundance of gH-gL
CC       complexes in virion. Favors the incorporation of gL into virions once
CC       UL116 has regulated the early folding steps of virion assembly.
CC       Interacts with the host ERAD machinery and slows gO decay which would
CC       otherwise be constitutively degraded. Reorganizes the host endoplasmic
CC       reticulum and activates the unfolded protein response. Additionally,
CC       plays a role in the evasion of antiviral immune response by down-
CC       regulating cell surface expression of host CD58. Mechanistically,
CC       interacts with host CD58 and retains its immature form intracellularly.
CC       The capacity to cause endoplasmic reticulum reorganization and the
CC       intracellular retention of host CD58 are functionally independent
CC       properties. {ECO:0000250|UniProtKB:B8YEE5}.
CC   -!- SUBUNIT: Interacts with host SEL1L. {ECO:0000250|UniProtKB:B8YEE5}.
CC   -!- SUBCELLULAR LOCATION: Host endoplasmic reticulum membrane
CC       {ECO:0000250|UniProtKB:B8YEE5}; Single-pass type I membrane protein
CC       {ECO:0000250|UniProtKB:B8YEE5}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AY446894; AAR31672.1; -; Genomic_DNA.
DR   RefSeq; YP_081568.1; NC_006273.2.
DR   DNASU; 3077479; -.
DR   GeneID; 3077479; -.
DR   KEGG; vg:3077479; -.
DR   Reactome; R-HSA-9610379; HCMV Late Events.
DR   Proteomes; UP000000938; Genome.
DR   GO; GO:0044167; C:host cell endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0039503; P:suppression by virus of host innate immune response; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   Host endoplasmic reticulum; Host membrane; Host-virus interaction;
KW   Inhibition of host innate immune response by virus; Membrane;
KW   Reference proteome; Signal; Transmembrane; Transmembrane helix;
KW   Viral immunoevasion.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   CHAIN           21..316
FT                   /note="Membrane protein UL148"
FT                   /id="PRO_0000418261"
FT   TRANSMEM        286..308
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   316 AA;  36504 MW;  8B6BFA7ADB6ACF13 CRC64;
     MLRLLFTLVL LALYGPSVDA SRDYVHVRLL SYRGDPLVFK HTFSGVRRPF TELGWAACRD
     WDSMHCTPFW STDLEQMTDS VRRYSTVSPG KEVTLQLHGN QTVQPSFLSF TCRLQLEPVV
     ENVGLYVAYV VNDGERPQQF FTPQVDVVRF ALYLETLSRI VEPLESGRLT VEFDTPDLAL
     APDLVSSLFV AGHGETDFYM NWTLRRSQTH YLEEMALQVE ILKPRGVRHR AIIHHPKLQP
     GVGLWIDFCV YRYNARLTRG YVRYTLSPKA RLPAKAEGWL VSLDRFIVQY LNTLLITMMA
     AIWARVLITY LVSRRR