ID   UL16P_HCMVM             Reviewed;         230 AA.
AC   F5HG68;
DT   11-JUL-2012, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   23-FEB-2022, entry version 29.
DE   RecName: Full=Protein UL16;
DE   Flags: Precursor;
GN   Name=UL16;
OS   Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Cytomegalovirus.
OX   NCBI_TaxID=295027;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15105547; DOI=10.1099/vir.0.79888-0;
RA   Dolan A., Cunningham C., Hector R.D., Hassan-Walker A.F., Lee L.,
RA   Addison C., Dargan D.J., McGeoch D.J., Gatherer D., Emery V.C.,
RA   Griffiths P.D., Sinzger C., McSharry B.P., Wilkinson G.W.G., Davison A.J.;
RT   "Genetic content of wild-type human cytomegalovirus.";
RL   J. Gen. Virol. 85:1301-1312(2004).
CC   -!- FUNCTION: Plays a role in the escape of host immune response. Blocks
CC       the interaction between the host KLRK1 receptor with their ligand ULBP1
CC       and ULBP2. ULBPs activate multiple signaling pathways in primary NK
CC       cells, resulting in the production of cytokines and chemokines.
CC       Therefore, the sequestration of diverse KLRK1 ligands in the
CC       endoplasmic reticulum and cis-Golgi apparatus of cells by UL16 inhibits
CC       the activation of NK cells (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with host ULBP1, ULBP2 and MICB. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Host membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the HHV-5 UL16 protein family. {ECO:0000305}.
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DR   EMBL; AY446894; AAR31581.1; -; Genomic_DNA.
DR   RefSeq; YP_081475.1; NC_006273.2.
DR   SMR; F5HG68; -.
DR   PRIDE; F5HG68; -.
DR   DNASU; 3077464; -.
DR   GeneID; 3077464; -.
DR   KEGG; vg:3077464; -.
DR   Reactome; R-HSA-9609690; HCMV Early Events.
DR   Proteomes; UP000000938; Genome.
DR   GO; GO:0033644; C:host cell membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.1990; -; 1.
DR   InterPro; IPR038671; HCMV_UL16_sf.
DR   InterPro; IPR035123; UL16.
DR   Pfam; PF17622; UL16; 1.
PE   3: Inferred from homology;
KW   Glycoprotein; Host membrane; Membrane; Reference proteome; Signal;
KW   Transmembrane; Transmembrane helix.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..230
FT                   /note="Protein UL16"
FT                   /id="PRO_0000418245"
FT   TOPO_DOM        22..184
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        185..205
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        206..230
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        35
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        41
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        68
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        84
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        95
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        101
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        132
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        145
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   230 AA;  26187 MW;  51E1ACED95265011 CRC64;
     MERRRGTVPL GWVFFVLCLS ASSPCAVDLG SKSSNSTCRL NVTELASIHP GETWTLHGMC
     ISICYYENVT EDEIIGVAFT WQHNESVVDL WLYQNDTVIR NFSDITTNIL QDGLKMRTVP
     VTKLYTSRMV TNLTVGRYDC LRCENGTMKI IERLYVRLGS LYPRPPGSGL AKHPSVSADE
     ELSATLARDI VLVSAITLFF FLLALRIPQR LCQRLRIRLP HRYQRLRTED