ID   UL18_HCMVM              Reviewed;         368 AA.
AC   F5HFB4;
DT   11-JUL-2012, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   23-FEB-2022, entry version 42.
DE   RecName: Full=Membrane glycoprotein UL18;
DE   Flags: Precursor;
GN   Name=UL18;
OS   Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Cytomegalovirus.
OX   NCBI_TaxID=295027;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15105547; DOI=10.1099/vir.0.79888-0;
RA   Dolan A., Cunningham C., Hector R.D., Hassan-Walker A.F., Lee L.,
RA   Addison C., Dargan D.J., McGeoch D.J., Gatherer D., Emery V.C.,
RA   Griffiths P.D., Sinzger C., McSharry B.P., Wilkinson G.W.G., Davison A.J.;
RT   "Genetic content of wild-type human cytomegalovirus.";
RL   J. Gen. Virol. 85:1301-1312(2004).
CC   -!- FUNCTION: Plays a role in the protection against host NK cell
CC       cytotoxicity by interacting with and modulating the activity of the
CC       host inhibitory leukocyte Ig-like receptor 1/LILRB1, which is expressed
CC       on monocytes, dendritic cells, as well as subsets of T and NK cells.
CC       UL18 exerts an inhibitory effect on LIR-1+ NK cells, while it
CC       stimulates LIR-1- NK cell (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with host LILRB1. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Host membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AY446894; AAR31583.1; -; Genomic_DNA.
DR   RefSeq; YP_081477.1; NC_006273.2.
DR   SMR; F5HFB4; -.
DR   PRIDE; F5HFB4; -.
DR   DNASU; 3077466; -.
DR   GeneID; 3077466; -.
DR   KEGG; vg:3077466; -.
DR   Reactome; R-HSA-9610379; HCMV Late Events.
DR   Proteomes; UP000000938; Genome.
DR   GO; GO:0033644; C:host cell membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW.
DR   GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW.
DR   GO; GO:0039671; P:evasion by virus of host natural killer cell activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.10; -; 1.
DR   Gene3D; 3.30.500.10; -; 1.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR011161; MHC_I-like_Ag-recog.
DR   InterPro; IPR037055; MHC_I-like_Ag-recog_sf.
DR   InterPro; IPR011162; MHC_I/II-like_Ag-recog.
DR   Pfam; PF00129; MHC_I; 1.
DR   SUPFAM; SSF48726; SSF48726; 1.
DR   SUPFAM; SSF54452; SSF54452; 1.
PE   3: Inferred from homology;
KW   Glycoprotein; Host membrane; Host-virus interaction; Immunity; Membrane;
KW   MHC I; Modulation of host NK-cell activity by virus; Reference proteome;
KW   Signal; Transmembrane; Transmembrane helix; Viral immunoevasion.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..368
FT                   /note="Membrane glycoprotein UL18"
FT                   /id="PRO_0000418297"
FT   TRANSMEM        326..346
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   368 AA;  41730 MW;  3E814AE4A8033A12 CRC64;
     MMTMWCLTLF VLWMLRVVGM HVLRYGYTGI FDDTSHMTLT VVGIFDGQHF FTYHVNSSDK
     ASSRANGTIS WMANVSAAYP TYLDGERAKG DLIFNQTEQN LLELEIALGY RSQSVLTWTH
     ECNTTENGSF VAGYEGFGWD GETLMELKDN LTLWTGPNYE ISWLKQNKTY IDGKIKNISE
     GDTTIQRNYL KGNCTQWSVI YSGFQTPVTH PVVKGGVRNQ NDNRAEAFCT SYGFFPGEIN
     ITFIHYGNKA PDDSEPQCNP LLPTFDGTFH QGCYVAIFCN QNYTCRVTHG NWTVEIPISV
     TSPDDSSSGE VPDHPTANKR YNTMTISSVL LALLLCALLF AFLHYFTTLK QYLRNLAFAW
     RYRKVRSS