ID   UL20_EHV1V              Reviewed;         239 AA.
AC   P84392; Q6S6T0;
DT   15-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 1.
DT   29-SEP-2021, entry version 41.
DE   RecName: Full=Protein UL20 homolog;
GN   OrderedLocusNames=41;
OS   Equine herpesvirus 1 (strain V592) (EHV-1) (Equine abortion virus).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Alphaherpesvirinae; Varicellovirus.
OX   NCBI_TaxID=310273;
OH   NCBI_TaxID=9796; Equus caballus (Horse).
RN   [1] {ECO:0000305, ECO:0000312|EMBL:AAS45926.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Davis-Poynter N., Nugent J., Birch-Machin I., Allen G.P.;
RL   Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an essential role in egress of virus particles from the
CC       nucleus, cytoplasmic envelopment and virus-induced cell fusion. Forms a
CC       functional protein complex with gK and this interaction is absolutely
CC       essential for their coordinate intracellular transport, gK
CC       glycosylation, expression on host cell surface, and function. Together,
CC       they modulate gB-mediated virus-induced cell fusion and virion egress
CC       and therefore actively participate in these processes (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with gK (via N-terminus); this interaction plays a
CC       role in the coordinate transport of UL20 and gK to the trans-Golgi
CC       network (TGN), and is required for their cell surface expression.
CC       Interacts with gB (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000250}. Host cell membrane
CC       {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Host endosome
CC       membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Host
CC       Golgi apparatus membrane {ECO:0000250}; Multi-pass membrane protein
CC       {ECO:0000250}. Host nucleus membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}. Note=During virion morphogenesis, this protein
CC       probably accumulates in the endosomes and trans-Golgi where secondary
CC       envelopment occurs. It is probably transported with gK to the cell
CC       surface from where it is endocytosed and directed to the trans-Golgi
CC       network (TGN) (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the alphaherpesvirinae UL20 family.
CC       {ECO:0000305}.
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DR   EMBL; AY464052; AAS45926.1; -; Genomic_DNA.
DR   RefSeq; YP_053087.1; NC_001491.2.
DR   GeneID; 1487525; -.
DR   KEGG; vg:1487525; -.
DR   Proteomes; UP000008296; Genome.
DR   GO; GO:0044175; C:host cell endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0044178; C:host cell Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0044200; C:host cell nuclear membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0019058; P:viral life cycle; IEA:InterPro.
DR   InterPro; IPR007629; Herpes_UL20.
DR   Pfam; PF04544; Herpes_UL20; 1.
PE   3: Inferred from homology;
KW   Host cell membrane; Host endosome; Host Golgi apparatus; Host membrane;
KW   Host nucleus; Membrane; Transmembrane; Transmembrane helix; Virion.
FT   CHAIN           1..239
FT                   /note="Protein UL20 homolog"
FT                   /id="PRO_0000115968"
FT   TRANSMEM        73..95
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        102..124
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        139..161
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        198..220
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   239 AA;  26535 MW;  6DDAC421FDAC61AD CRC64;
     MPQVLMGNTR LHAPLEDGIP LIENDENSSQ NEVDLYDYVS MSSYGGDNDF LISSAGGNIT
     PENRPSFSAH VVLFAISALV IKPVCCFIFL NHYVITGSYD FAVAGGVCTV LYYMRLALTA
     WFMFRNIQSD MLPLNVWQQF VIGCMALGRT VAFMVVSYTT LFIRSELFFS MLAPNAGREY
     ITPIIAHKLM PLISVRSAVC LVIISTAVYA ADAICDTIGF TLPRMWMCIL MRSSSVKRS