ID   UL20_GAHVM              Reviewed;         234 AA.
AC   Q77MS4;
DT   05-APR-2011, integrated into UniProtKB/Swiss-Prot.
DT   13-OCT-2009, sequence version 1.
DT   29-SEP-2021, entry version 27.
DE   RecName: Full=Protein UL20 homolog;
GN   Name=MDV032;
OS   Gallid herpesvirus 2 (strain Chicken/Md5/ATCC VR-987) (GaHV-2) (Marek's
OS   disease herpesvirus type 1).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Alphaherpesvirinae; Mardivirus.
OX   NCBI_TaxID=10389;
OH   NCBI_TaxID=9031; Gallus gallus (Chicken).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=10933706; DOI=10.1128/jvi.74.17.7980-7988.2000;
RA   Tulman E.R., Afonso C.L., Lu Z., Zsak L., Rock D.L., Kutish G.F.;
RT   "The genome of a very virulent Marek's disease virus.";
RL   J. Virol. 74:7980-7988(2000).
CC   -!- FUNCTION: Plays an essential role in egress of virus particles from the
CC       nucleus, cytoplasmic envelopment and virus-induced cell fusion. Forms a
CC       functional protein complex with gK and this interaction is absolutely
CC       essential for their coordinate intracellular transport, gK
CC       glycosylation, expression on host cell surface, and function. Together,
CC       they modulate gB-mediated virus-induced cell fusion and virion egress
CC       and therefore actively participate in these processes (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with gK (via N-terminus); this interaction plays a
CC       role in the coordinate transport of UL20 and gK to the trans-Golgi
CC       network (TGN), and is required for their cell surface expression.
CC       Interacts with gB (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000250}. Host cell membrane
CC       {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Host endosome
CC       membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Host
CC       Golgi apparatus membrane {ECO:0000250}; Multi-pass membrane protein
CC       {ECO:0000250}. Host nucleus membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}. Note=During virion morphogenesis, this protein
CC       probably accumulates in the endosomes and trans-Golgi where secondary
CC       envelopment occurs. It is probably transported with gK to the cell
CC       surface from where it is endocytosed and directed to the trans-Golgi
CC       network (TGN) (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the alphaherpesvirinae UL20 family.
CC       {ECO:0000305}.
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DR   EMBL; AF243438; AAG14212.1; -; Genomic_DNA.
DR   RefSeq; YP_001033948.1; NC_002229.3.
DR   GeneID; 4811493; -.
DR   KEGG; vg:4811493; -.
DR   Proteomes; UP000008072; Genome.
DR   GO; GO:0044175; C:host cell endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0044178; C:host cell Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0044200; C:host cell nuclear membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0019058; P:viral life cycle; IEA:InterPro.
DR   InterPro; IPR007629; Herpes_UL20.
DR   Pfam; PF04544; Herpes_UL20; 1.
PE   3: Inferred from homology;
KW   Host cell membrane; Host endosome; Host Golgi apparatus; Host membrane;
KW   Host nucleus; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Virion.
FT   CHAIN           1..234
FT                   /note="Protein UL20 homolog"
FT                   /id="PRO_0000406525"
FT   TRANSMEM        82..102
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        112..132
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        153..173
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        191..211
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   234 AA;  26583 MW;  8673B95A1B99825F CRC64;
     MSKHGFGYYA TEANEYTIPL DDIDDGRSDT DAKTLGSVLT QLSEEVDWDD AVDYATMSSY
     LGDYVFTIPN SYDIHPKFTR YVVLFGLSTF VLRPSCCLIF LFYAIYAQDN RFLILGTTIT
     AFFYGTLMLE MYYMYANIKY DLMPLSKFQQ VLIGALSMLG PIIFVAISYN MIFKDVTFMK
     KILAFDTNLK TSGFVIYLVM IASLAYSITS ISDAIGFLLP RLWTRAVLKS CVPF