CA14_CONMN
ID CA14_CONMN Reviewed; 17 AA.
AC P0C8U5;
DT 03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 03-MAR-2009, sequence version 1.
DT 25-MAY-2022, entry version 29.
DE RecName: Full=Alpha-conotoxin-like Mn1.4;
DE Flags: Precursor; Fragment;
OS Conus monachus (Cone snail).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Pionoconus.
OX NCBI_TaxID=89446;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND REVIEW.
RC TISSUE=Venom duct;
RX PubMed=16905531; DOI=10.1074/jbc.r600020200;
RA Olivera B.M.;
RT "Conus peptides: biodiversity-based discovery and exogenomics.";
RL J. Biol. Chem. 281:31173-31177(2006).
CC -!- FUNCTION: Alpha-conotoxins act on postsynaptic membranes, they bind to
CC the nicotinic acetylcholine receptors (nAChR) and thus inhibit them.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC -!- DOMAIN: The cysteine framework is I (CC-C-C). Alpha3/5 pattern.
CC -!- SIMILARITY: Belongs to the conotoxin A superfamily. {ECO:0000305}.
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DR AlphaFoldDB; P0C8U5; -.
DR ConoServer; 3637; Mn1.4 precursor.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0035792; C:host cell postsynaptic membrane; IEA:UniProtKB-KW.
DR GO; GO:0030550; F:acetylcholine receptor inhibitor activity; IEA:UniProtKB-KW.
DR GO; GO:0099106; F:ion channel regulator activity; IEA:UniProtKB-KW.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR InterPro; IPR018072; Conotoxin_a-typ_CS.
DR PROSITE; PS60014; ALPHA_CONOTOXIN; 1.
PE 2: Evidence at transcript level;
KW Acetylcholine receptor inhibiting toxin; Amidation; Disulfide bond;
KW Ion channel impairing toxin; Neurotoxin; Postsynaptic neurotoxin; Secreted;
KW Toxin.
FT PROPEP <1..1
FT /id="PRO_0000366056"
FT PEPTIDE 2..15
FT /note="Alpha-conotoxin-like Mn1.4"
FT /id="PRO_0000366057"
FT MOD_RES 15
FT /note="Cysteine amide"
FT /evidence="ECO:0000250"
FT DISULFID 4..9
FT /evidence="ECO:0000250|UniProtKB:P01519"
FT DISULFID 5..15
FT /evidence="ECO:0000250|UniProtKB:P01519"
FT NON_TER 1
SQ SEQUENCE 17 AA; 1873 MW; 635B9EEE83069BF0 CRC64;
NGRCCHPACA KYFSCGR