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CA14_CONMN
ID   CA14_CONMN              Reviewed;          17 AA.
AC   P0C8U5;
DT   03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   03-MAR-2009, sequence version 1.
DT   25-MAY-2022, entry version 29.
DE   RecName: Full=Alpha-conotoxin-like Mn1.4;
DE   Flags: Precursor; Fragment;
OS   Conus monachus (Cone snail).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Pionoconus.
OX   NCBI_TaxID=89446;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND REVIEW.
RC   TISSUE=Venom duct;
RX   PubMed=16905531; DOI=10.1074/jbc.r600020200;
RA   Olivera B.M.;
RT   "Conus peptides: biodiversity-based discovery and exogenomics.";
RL   J. Biol. Chem. 281:31173-31177(2006).
CC   -!- FUNCTION: Alpha-conotoxins act on postsynaptic membranes, they bind to
CC       the nicotinic acetylcholine receptors (nAChR) and thus inhibit them.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC   -!- DOMAIN: The cysteine framework is I (CC-C-C). Alpha3/5 pattern.
CC   -!- SIMILARITY: Belongs to the conotoxin A superfamily. {ECO:0000305}.
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DR   AlphaFoldDB; P0C8U5; -.
DR   ConoServer; 3637; Mn1.4 precursor.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0035792; C:host cell postsynaptic membrane; IEA:UniProtKB-KW.
DR   GO; GO:0030550; F:acetylcholine receptor inhibitor activity; IEA:UniProtKB-KW.
DR   GO; GO:0099106; F:ion channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR018072; Conotoxin_a-typ_CS.
DR   PROSITE; PS60014; ALPHA_CONOTOXIN; 1.
PE   2: Evidence at transcript level;
KW   Acetylcholine receptor inhibiting toxin; Amidation; Disulfide bond;
KW   Ion channel impairing toxin; Neurotoxin; Postsynaptic neurotoxin; Secreted;
KW   Toxin.
FT   PROPEP          <1..1
FT                   /id="PRO_0000366056"
FT   PEPTIDE         2..15
FT                   /note="Alpha-conotoxin-like Mn1.4"
FT                   /id="PRO_0000366057"
FT   MOD_RES         15
FT                   /note="Cysteine amide"
FT                   /evidence="ECO:0000250"
FT   DISULFID        4..9
FT                   /evidence="ECO:0000250|UniProtKB:P01519"
FT   DISULFID        5..15
FT                   /evidence="ECO:0000250|UniProtKB:P01519"
FT   NON_TER         1
SQ   SEQUENCE   17 AA;  1873 MW;  635B9EEE83069BF0 CRC64;
     NGRCCHPACA KYFSCGR
 
 
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