UL20_HCMVM
ID UL20_HCMVM Reviewed; 338 AA.
AC F5H9Z4;
DT 11-JUL-2012, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 1.
DT 03-AUG-2022, entry version 24.
DE RecName: Full=Membrane protein UL20;
GN Name=UL20;
OS Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5).
OC Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC Herpesvirales; Herpesviridae; Betaherpesvirinae; Cytomegalovirus.
OX NCBI_TaxID=295027;
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15105547; DOI=10.1099/vir.0.79888-0;
RA Dolan A., Cunningham C., Hector R.D., Hassan-Walker A.F., Lee L.,
RA Addison C., Dargan D.J., McGeoch D.J., Gatherer D., Emery V.C.,
RA Griffiths P.D., Sinzger C., McSharry B.P., Wilkinson G.W.G., Davison A.J.;
RT "Genetic content of wild-type human cytomegalovirus.";
RL J. Gen. Virol. 85:1301-1312(2004).
CC -!- SUBCELLULAR LOCATION: Host endoplasmic reticulum membrane
CC {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
CC Note=Does not reach the host cell surface but is rapidely targeted to
CC endosomes and lysosomes. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the HHV-5 UL20 protein family. {ECO:0000305}.
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DR EMBL; AY446894; AAR31585.1; -; Genomic_DNA.
DR RefSeq; YP_081479.1; NC_006273.2.
DR DNASU; 3077434; -.
DR GeneID; 3077434; -.
DR KEGG; vg:3077434; -.
DR Proteomes; UP000000938; Genome.
DR GO; GO:0044167; C:host cell endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR035142; UL20.
DR Pfam; PF17582; UL20; 1.
PE 3: Inferred from homology;
KW Glycoprotein; Host endoplasmic reticulum; Host membrane; Membrane;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..338
FT /note="Membrane protein UL20"
FT /id="PRO_0000418246"
FT TOPO_DOM 26..223
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 224..244
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 245..338
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 27
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT CARBOHYD 54
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT CARBOHYD 57
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT CARBOHYD 68
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT CARBOHYD 73
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT CARBOHYD 79
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT CARBOHYD 84
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT CARBOHYD 108
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT CARBOHYD 119
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT CARBOHYD 143
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT CARBOHYD 171
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT CARBOHYD 178
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
SQ SEQUENCE 338 AA; 38330 MW; A7FF32248B36C116 CRC64;
MLGIRAMLVM LDYYWIQLIT NNGTRSNNTD TIFVSLLTGP NGVTRTAIGG LYSNYTNLTG
AFGFTSTNMS ATNSSAEDNW SVTNLTESCI NRGESYVTTI WLLDCTKNDT YWYYGNAYNH
TCEGTISGYL LGMCKLWKSW VNNITSYNTV RVESLGNETR CMLLPRQYTL NATVEWYNKS
EGDVPEEFMD YVILTPLAVL TCGLQEAYIL DKGRRYMYLF SVSCVGITGT VSIILVSLSL
LILICYYRCG RLLICPRGFE LLPEFTEEEE EKEKLLTHND IEVQVPIRTR RLLVPWIRES
KMWVLPPPLP PRPPHLIEFP PSPPPSPGPM HMVVCMPA
