ID   UL20_HHV2H              Reviewed;         222 AA.
AC   P89443;
DT   05-APR-2011, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1997, sequence version 1.
DT   29-SEP-2021, entry version 58.
DE   RecName: Full=Protein UL20;
GN   Name=UL20;
OS   Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Alphaherpesvirinae; Simplexvirus.
OX   NCBI_TaxID=10315;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=1662697; DOI=10.1099/0022-1317-72-12-3057;
RA   McGeoch D.J., Cunningham C., McIntyre G., Dolan A.;
RT   "Comparative sequence analysis of the long repeat regions and adjoining
RT   parts of the long unique regions in the genomes of herpes simplex viruses
RT   types 1 and 2.";
RL   J. Gen. Virol. 72:3057-3075(1991).
CC   -!- FUNCTION: Plays an essential role in egress of virus particles from the
CC       nucleus, cytoplasmic envelopment and virus-induced cell fusion. Forms a
CC       functional protein complex with gK and this interaction is absolutely
CC       essential for their coordinate intracellular transport, gK
CC       glycosylation, expression on host cell surface, and function. Together,
CC       they modulate gB-mediated virus-induced cell fusion and virion egress
CC       and therefore actively participate in these processes (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with gK (via N-terminus); this interaction plays a
CC       role in the coordinate transport of UL20 and gK to the trans-Golgi
CC       network (TGN), and is required for their cell surface expression.
CC       Interacts with gB (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000250}. Host cell membrane
CC       {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Host endosome
CC       membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Host
CC       Golgi apparatus membrane {ECO:0000250}; Multi-pass membrane protein
CC       {ECO:0000250}. Host nucleus membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}. Note=During virion morphogenesis, this protein
CC       probably accumulates in the endosomes and trans-Golgi where secondary
CC       envelopment occurs. It is probably transported with gK to the cell
CC       surface from where it is endocytosed and directed to the trans-Golgi
CC       network (TGN) (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the alphaherpesvirinae UL20 family.
CC       {ECO:0000305}.
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DR   EMBL; Z86099; CAB06744.1; -; Genomic_DNA.
DR   RefSeq; YP_009137171.1; NC_001798.2.
DR   PRIDE; P89443; -.
DR   DNASU; 24271455; -.
DR   GeneID; 24271455; -.
DR   KEGG; vg:24271455; -.
DR   Proteomes; UP000001874; Genome.
DR   GO; GO:0044175; C:host cell endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0044178; C:host cell Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0044200; C:host cell nuclear membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0019058; P:viral life cycle; IEA:InterPro.
DR   InterPro; IPR007629; Herpes_UL20.
DR   Pfam; PF04544; Herpes_UL20; 1.
PE   3: Inferred from homology;
KW   Host cell membrane; Host endosome; Host Golgi apparatus; Host membrane;
KW   Host nucleus; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Virion.
FT   CHAIN           1..222
FT                   /note="Protein UL20"
FT                   /id="PRO_0000406177"
FT   TRANSMEM        64..84
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        98..118
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        131..151
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        182..202
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   222 AA;  24263 MW;  F6EFA136F654E722 CRC64;
     MTMRDDVPLL DRELVDEAAC GGEDGELPLD EQFSLSSYGT SDFFVSSAYS RLPPHTQPVF
     SKRVVMFAWS FLVLKPLELV AAGMYYGWTG RAVAPACIIA AVLAYYVTWL ARALLLYVNI
     KRDRLPLSPP VFWGLCVIMG GAALCALVAA AHETFSPDGL FHWITASQLL PRTDPLRARS
     LGIACAAGAA MWVAAADCFA AFTNFFLARF WTRAILKAPV AF