ID   UL20_PSHV1              Reviewed;         248 AA.
AC   Q6UDI5;
DT   05-APR-2011, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   29-SEP-2021, entry version 37.
DE   RecName: Full=Protein UL20;
GN   Name=UL20;
OS   Psittacid herpesvirus 1 (isolate Amazon parrot/-/97-0001/1997) (PsHV-1)
OS   (Pacheco's disease virus).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Alphaherpesvirinae; Iltovirus.
OX   NCBI_TaxID=670426;
OH   NCBI_TaxID=152276; Amazona oratrix (yellow-headed parrot).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16873243; DOI=10.1128/jvi.00134-06;
RA   Thureen D.R., Keeler C.L. Jr.;
RT   "Psittacid herpesvirus 1 and infectious laryngotracheitis virus:
RT   Comparative genome sequence analysis of two avian alphaherpesviruses.";
RL   J. Virol. 80:7863-7872(2006).
CC   -!- FUNCTION: Plays an essential role in egress of virus particles from the
CC       nucleus, cytoplasmic envelopment and virus-induced cell fusion. Forms a
CC       functional protein complex with gK and this interaction is absolutely
CC       essential for their coordinate intracellular transport, gK
CC       glycosylation, expression on host cell surface, and function. Together,
CC       they modulate gB-mediated virus-induced cell fusion and virion egress
CC       and therefore actively participate in these processes (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with gK (via N-terminus); this interaction plays a
CC       role in the coordinate transport of UL20 and gK to the trans-Golgi
CC       network (TGN), and is required for their cell surface expression.
CC       Interacts with gB (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000250}. Host cell membrane
CC       {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Host endosome
CC       membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Host
CC       Golgi apparatus membrane {ECO:0000250}; Multi-pass membrane protein
CC       {ECO:0000250}. Host nucleus membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}. Note=During virion morphogenesis, this protein
CC       probably accumulates in the endosomes and trans-Golgi where secondary
CC       envelopment occurs. It is probably transported with gK to the cell
CC       surface from where it is endocytosed and directed to the trans-Golgi
CC       network (TGN) (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the alphaherpesvirinae UL20 family.
CC       {ECO:0000305}.
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DR   EMBL; AY372243; AAQ73725.1; -; Genomic_DNA.
DR   RefSeq; NP_944419.1; NC_005264.1.
DR   GeneID; 2656981; -.
DR   KEGG; vg:2656981; -.
DR   Proteomes; UP000006840; Genome.
DR   GO; GO:0044175; C:host cell endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0044178; C:host cell Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0044200; C:host cell nuclear membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0019058; P:viral life cycle; IEA:InterPro.
DR   InterPro; IPR007629; Herpes_UL20.
DR   Pfam; PF04544; Herpes_UL20; 1.
PE   3: Inferred from homology;
KW   Host cell membrane; Host endosome; Host Golgi apparatus; Host membrane;
KW   Host nucleus; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Virion.
FT   CHAIN           1..248
FT                   /note="Protein UL20"
FT                   /id="PRO_0000406863"
FT   TRANSMEM        82..102
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        114..134
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        153..173
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        218..238
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   248 AA;  26600 MW;  373EE485D08A88DC CRC64;
     MADASAPDKK NAPTNALKPD LIKIAVERVL AAIDTENNED LILAAAREPR EVVAARAPDL
     FTSAAYSWSE EDELGTRMRA SSFFPVASMF AKIICCLFLL WAKSCTGHGA MVTGLTACTG
     AYAIASLLCS FVVYYNVRTD NMPFGTYTKL FQIAACIGCG CYALGLTMEK LFGDSEMYFA
     LFPDAKNSPL VGATAKGSAL ILPQGCSVAP YVPLAVSVAY CAAVVYDIAD TIFPLLWVRT
     TLNEFAVF