UL20_VZVD
ID UL20_VZVD Reviewed; 240 AA.
AC P09290;
DT 01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1989, sequence version 1.
DT 29-SEP-2021, entry version 62.
DE RecName: Full=Protein UL20 homolog;
DE AltName: Full=Gene 39 membrane protein;
GN Name=39;
OS Varicella-zoster virus (strain Dumas) (HHV-3) (Human herpesvirus 3).
OC Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC Herpesvirales; Herpesviridae; Alphaherpesvirinae; Varicellovirus.
OX NCBI_TaxID=10338;
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=3018124; DOI=10.1099/0022-1317-67-9-1759;
RA Davison A.J., Scott J.E.;
RT "The complete DNA sequence of varicella-zoster virus.";
RL J. Gen. Virol. 67:1759-1816(1986).
CC -!- FUNCTION: Plays an essential role in egress of virus particles from the
CC nucleus, cytoplasmic envelopment and virus-induced cell fusion. Forms a
CC functional protein complex with gK and this interaction is absolutely
CC essential for their coordinate intracellular transport, gK
CC glycosylation, expression on host cell surface, and function. Together,
CC they modulate gB-mediated virus-induced cell fusion and virion egress
CC and therefore actively participate in these processes (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: Interacts with gK (via N-terminus); this interaction plays a
CC role in the coordinate transport of UL20 and gK to the trans-Golgi
CC network (TGN), and is required for their cell surface expression.
CC Interacts with gB (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Virion {ECO:0000250}. Host cell membrane
CC {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Host endosome
CC membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Host
CC Golgi apparatus membrane {ECO:0000250}; Multi-pass membrane protein
CC {ECO:0000250}. Host nucleus membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}. Note=During virion morphogenesis, this protein
CC probably accumulates in the endosomes and trans-Golgi where secondary
CC envelopment occurs. It is probably transported with gK to the cell
CC surface from where it is endocytosed and directed to the trans-Golgi
CC network (TGN) (By similarity). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the alphaherpesvirinae UL20 family.
CC {ECO:0000305}.
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DR EMBL; X04370; CAA27922.1; -; Genomic_DNA.
DR PIR; D27341; WZBE39.
DR PRIDE; P09290; -.
DR Proteomes; UP000002602; Genome.
DR GO; GO:0044175; C:host cell endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0044178; C:host cell Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0044200; C:host cell nuclear membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0019058; P:viral life cycle; IEA:InterPro.
DR InterPro; IPR007629; Herpes_UL20.
DR Pfam; PF04544; Herpes_UL20; 1.
PE 3: Inferred from homology;
KW Host cell membrane; Host endosome; Host Golgi apparatus; Host membrane;
KW Host nucleus; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Virion.
FT CHAIN 1..240
FT /note="Protein UL20 homolog"
FT /id="PRO_0000115969"
FT TRANSMEM 76..96
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 104..124
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 147..167
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 203..225
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 240 AA; 27079 MW; 4165D7BC3BCD93F3 CRC64;
MNPPQARVSE QTKDLLSVMV NQHPEEDAKV CKSSDNSPLY NTMVMLSYGG DTDLLLSSAC
TRTSTVNRSA FTQHSVFYII STVLIQPICC IFFFFYYKAT RCMLLFTAGL LLTILHHFRL
IIMLLCVYRN IRSDLLPLST SQQLLLGIIV VTRTMLFCIT AYYTLFIDTR VFFLITGHLQ
SEVIFPDSVS KILPVSWGPS PAVLLVMAAV IYAMDCLVDT VSFIGPRVWV RVMLKTSISF