ID   UL21A_HCMVA             Reviewed;         123 AA.
AC   Q7M6R1;
DT   15-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-DEC-2003, sequence version 1.
DT   03-AUG-2022, entry version 45.
DE   RecName: Full=Uncharacterized protein UL21A;
GN   Name=UL21A;
OS   Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Cytomegalovirus.
OX   NCBI_TaxID=10360;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=2161319; DOI=10.1007/978-3-642-74980-3_6;
RA   Chee M.S., Bankier A.T., Beck S., Bohni R., Brown C.M., Cerny R.,
RA   Horsnell T., Hutchison C.A. III, Kouzarides T., Martignetti J.A.,
RA   Preddie E., Satchwell S.C., Tomlinson P., Weston K.M., Barrell B.G.;
RT   "Analysis of the protein-coding content of the sequence of human
RT   cytomegalovirus strain AD169.";
RL   Curr. Top. Microbiol. Immunol. 154:125-169(1990).
RN   [2]
RP   GENOME REANNOTATION.
RX   PubMed=12533697; DOI=10.1099/vir.0.18606-0;
RA   Davison A.J., Dolan A., Akter P., Addison C., Dargan D.J., Alcendor D.J.,
RA   McGeoch D.J., Hayward G.S.;
RT   "The human cytomegalovirus genome revisited: comparison with the chimpanzee
RT   cytomegalovirus genome.";
RL   J. Gen. Virol. 84:17-28(2003).
RN   [3]
RP   ERRATUM OF PUBMED:12533697.
RA   Davison A.J., Dolan A., Akter P., Addison C., Dargan D.J., Alcendor D.J.,
RA   McGeoch D.J., Hayward G.S.;
RL   J. Gen. Virol. 84:1053-1053(2003).
RN   [4]
RP   SUBCELLULAR LOCATION.
RX   PubMed=19846516; DOI=10.1128/jvi.01116-09;
RA   Fehr A.R., Yu D.;
RT   "Human cytomegalovirus gene UL21a encodes a short-lived cytoplasmic protein
RT   and facilitates virus replication in fibroblasts.";
RL   J. Virol. 84:291-302(2010).
RN   [5]
RP   FUNCTION.
RX   PubMed=21047969; DOI=10.1128/jvi.01599-10;
RA   Fehr A.R., Yu D.;
RT   "Human cytomegalovirus early protein pUL21a promotes efficient viral DNA
RT   synthesis and the late accumulation of immediate-early transcripts.";
RL   J. Virol. 85:663-674(2011).
CC   -!- FUNCTION: Required for efficient viral DNA synthesis and the late
CC       accumulation of viral IE transcripts. {ECO:0000269|PubMed:21047969}.
CC   -!- SUBCELLULAR LOCATION: Host cytoplasm {ECO:0000269|PubMed:19846516}.
CC   -!- SIMILARITY: Belongs to the HHV-5 UL21A protein family. {ECO:0000305}.
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DR   EMBL; X17403; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BK000394; DAA00125.1; -; Genomic_DNA.
DR   RefSeq; YP_081480.1; NC_006273.2.
DR   BioGRID; 1678001; 3.
DR   PRIDE; Q7M6R1; -.
DR   DNASU; 3077448; -.
DR   GeneID; 3077448; -.
DR   KEGG; vg:3077448; -.
DR   Proteomes; UP000008991; Genome.
DR   Proteomes; UP000008992; Genome.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   InterPro; IPR035112; UL21a.
DR   Pfam; PF17636; UL21a; 1.
PE   3: Inferred from homology;
KW   Host cytoplasm; Reference proteome.
FT   CHAIN           1..123
FT                   /note="Uncharacterized protein UL21A"
FT                   /id="PRO_0000115313"
SQ   SEQUENCE   123 AA;  14275 MW;  6596F9899D94F33D CRC64;
     MGGSPVPQLT TVTQGLMPSV RMDFRARRPL RRLAFYAPRA RRRLFQNHIH PEQRRVLVGE
     GDEEMLPDLP MEIDIVIDRP PQQPLPNPLV LLLDDVPPHV PGFAPYRVPR PHPMIPEEHW
     DQF