UL22A_HCMVA
ID UL22A_HCMVA Reviewed; 103 AA.
AC P16845; Q910H5; Q910K8; Q910L5; Q910N2; Q910S8; Q910U1; Q918F6; Q918F7;
AC Q918F8; Q918F9; Q918G0; Q918G1;
DT 01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT 15-FEB-2005, sequence version 2.
DT 29-SEP-2021, entry version 65.
DE RecName: Full=Glycoprotein UL22A;
DE Flags: Precursor;
GN Name=UL22A; Synonyms=UL20A;
OS Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5).
OC Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC Herpesvirales; Herpesviridae; Betaherpesvirinae; Cytomegalovirus.
OX NCBI_TaxID=10360;
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=2161319; DOI=10.1007/978-3-642-74980-3_6;
RA Chee M.S., Bankier A.T., Beck S., Bohni R., Brown C.M., Cerny R.,
RA Horsnell T., Hutchison C.A. III, Kouzarides T., Martignetti J.A.,
RA Preddie E., Satchwell S.C., Tomlinson P., Weston K.M., Barrell B.G.;
RT "Analysis of the protein-coding content of the sequence of human
RT cytomegalovirus strain AD169.";
RL Curr. Top. Microbiol. Immunol. 154:125-169(1990).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Isolate clinical 17A, Isolate clinical 19A, Isolate clinical 21A,
RC Isolate clinical 22A, Isolate clinical 27A, Isolate clinical 29A,
RC Isolate clinical 30A, Isolate clinical 33B, Isolate clinical 38A,
RC Isolate clinical 3A, Isolate clinical 44A, Isolate clinical 47A,
RC Isolate clinical 48A, Isolate clinical 49A, Isolate clinical 56A,
RC Isolate clinical 5A, Isolate clinical 79A, Isolate clinical 8A,
RC Isolate clinical 95A, and Isolate clinical 9A;
RX PubMed=11928987; DOI=10.1023/a:1014033920070;
RA Scott G.M., Barrell B.G., Oram J., Rawlinson W.D.;
RT "Characterisation of transcripts from the human cytomegalovirus genes TRL7,
RT UL20a, UL36, UL65, UL94, US3 and US34.";
RL Virus Genes 24:39-48(2002).
RN [3]
RP GENOME REANNOTATION.
RX PubMed=12533697; DOI=10.1099/vir.0.18606-0;
RA Davison A.J., Dolan A., Akter P., Addison C., Dargan D.J., Alcendor D.J.,
RA McGeoch D.J., Hayward G.S.;
RT "The human cytomegalovirus genome revisited: comparison with the chimpanzee
RT cytomegalovirus genome.";
RL J. Gen. Virol. 84:17-28(2003).
RN [4]
RP ERRATUM OF PUBMED:12533697.
RA Davison A.J., Dolan A., Akter P., Addison C., Dargan D.J., Alcendor D.J.,
RA McGeoch D.J., Hayward G.S.;
RL J. Gen. Virol. 84:1053-1053(2003).
RN [5]
RP IDENTIFICATION.
RX PubMed=15452216; DOI=10.1128/jvi.78.20.10960-10966.2004;
RA Varnum S.M., Streblow D.N., Monroe M.E., Smith P., Auberry K.J.,
RA Pasa-Tolic L., Wang D., Camp D.G. II, Rodland K., Wiley S., Britt W.,
RA Shenk T., Smith R.D., Nelson J.A.;
RT "Identification of proteins in human cytomegalovirus (HCMV) particles: the
RT HCMV proteome.";
RL J. Virol. 78:10960-10966(2004).
RN [6]
RP ERRATUM OF PUBMED:15452216.
RA Varnum S.M., Streblow D.N., Monroe M.E., Smith P., Auberry K.J.,
RA Pasa-Tolic L., Wang D., Camp D.G. II, Rodland K., Wiley S., Britt W.,
RA Shenk T., Smith R.D., Nelson J.A.;
RL J. Virol. 78:13395-13395(2004).
CC -!- SUBCELLULAR LOCATION: Virion.
CC -!- SIMILARITY: Belongs to the HHV-5 UL22A protein family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAA35421.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; X17403; CAA35421.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AF413626; AAL08513.1; -; Genomic_DNA.
DR EMBL; AF413627; AAL08514.1; -; Genomic_DNA.
DR EMBL; AF413628; AAL08515.1; -; Genomic_DNA.
DR EMBL; AF413629; AAL08516.1; -; Genomic_DNA.
DR EMBL; AF413630; AAL08517.1; -; Genomic_DNA.
DR EMBL; AF413631; AAL08518.1; -; Genomic_DNA.
DR EMBL; AF413632; AAL08519.1; -; Genomic_DNA.
DR EMBL; AF413633; AAL08520.1; -; Genomic_DNA.
DR EMBL; AF413634; AAL08521.1; -; Genomic_DNA.
DR EMBL; AF413635; AAL08522.1; -; Genomic_DNA.
DR EMBL; AF413636; AAL08523.1; -; Genomic_DNA.
DR EMBL; AF413637; AAL08524.1; -; Genomic_DNA.
DR EMBL; AF413638; AAL08525.1; -; Genomic_DNA.
DR EMBL; AF413639; AAL08526.1; -; Genomic_DNA.
DR EMBL; AF413640; AAL08527.1; -; Genomic_DNA.
DR EMBL; AF413641; AAL08528.1; -; Genomic_DNA.
DR EMBL; AF413642; AAL08529.1; -; Genomic_DNA.
DR EMBL; AF413643; AAL08530.1; -; Genomic_DNA.
DR EMBL; AF413644; AAL08531.1; -; Genomic_DNA.
DR EMBL; AF413645; AAL08532.1; -; Genomic_DNA.
DR EMBL; BK000394; DAA00126.1; -; Genomic_DNA.
DR PIR; S09785; S09785.
DR RefSeq; YP_081481.1; NC_006273.2.
DR GeneID; 3077571; -.
DR KEGG; vg:3077571; -.
DR Proteomes; UP000008991; Genome.
DR Proteomes; UP000008992; Genome.
DR InterPro; IPR009245; Cytomegalo_UL22A.
DR Pfam; PF05984; Cytomega_UL20A; 1.
PE 3: Inferred from homology;
KW Glycoprotein; Reference proteome; Signal; Virion.
FT SIGNAL 1..20
FT /evidence="ECO:0000255"
FT CHAIN 21..103
FT /note="Glycoprotein UL22A"
FT /id="PRO_0000037454"
FT REGION 21..103
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 21..61
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 81..103
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 49
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT VARIANT 5
FT /note="L -> V (in strain: Isolate clinical 48A)"
FT VARIANT 10
FT /note="Missing (in strain: Isolate clinical 17A, Isolate
FT clinical 27A, Isolate clinical 30A, Isolate clinical 33B,
FT Isolate clinical 47A, Isolate clinical 48A and Isolate
FT clinical 79A)"
FT VARIANT 33
FT /note="E -> K (in strain: Isolate clinical 5A, Isolate
FT clinical 44A and Isolate clinical 49A)"
FT VARIANT 39..42
FT /note="ADGS -> TNSDG (in strain: Isolate clinical 3A,
FT Isolate clinical 5A, Isolate clinical 17A, Isolate clinical
FT 19A, Isolate clinical 21A, Isolate clinical 22A, Isolate
FT clinical 27A, Isolate clinical 29A, Isolate clinical 30A,
FT Isolate clinical 33B, Isolate clinical 38A, Isolate
FT clinical 44A, Isolate clinical 47A, Isolate clinical 48A,
FT Isolate clinical 49A, Isolate clinical 56A and Isolate
FT clinical 79A)"
FT VARIANT 43
FT /note="N -> NN (in strain: Isolate clinical 29A and Isolate
FT clinical 38A)"
FT VARIANT 46..49
FT /note="PSKN -> RNKD (in strain: Isolate clinical 29A,
FT Isolate clinical 38A and Isolate clinical 56A)"
FT VARIANT 62
FT /note="D -> N (in strain: Isolate clinical 5A, Isolate
FT clinical 17A, Isolate clinical 30A, Isolate clinical 33B,
FT Isolate clinical 44A, Isolate clinical 47A, Isolate
FT clinical 48A, Isolate clinical 49A and Isolate clinical
FT 79A)"
FT VARIANT 68
FT /note="E -> EE (in strain: Isolate clinical 5A, Isolate
FT clinical 30A, Isolate clinical 33B, Isolate clinical 44A,
FT Isolate clinical 47A, Isolate clinical 48A, Isolate
FT clinical 49A and Isolate clinical 79A)"
FT VARIANT 68
FT /note="E -> GD (in strain: Isolate clinical 21A, Isolate
FT clinical 22A, Isolate clinical 29A, Isolate clinical 38A
FT and Isolate clinical 56A)"
FT VARIANT 76
FT /note="G -> T (in strain: Isolate clinical 21A, Isolate
FT clinical 22A, Isolate clinical 29A, Isolate clinical 38A
FT and Isolate clinical 56A)"
FT VARIANT 79
FT /note="S -> G (in strain: Isolate clinical 5A, Isolate
FT clinical 21A, Isolate clinical 22A, Isolate clinical 29A,
FT Isolate clinical 38A, Isolate clinical 44A, Isolate
FT clinical 49A and Isolate clinical 56A)"
FT VARIANT 80
FT /note="E -> N (in strain: Isolate clinical 21A, Isolate
FT clinical 22A, Isolate clinical 29A, Isolate clinical 38A
FT and Isolate clinical 56A)"
FT VARIANT 85
FT /note="Q -> QE (in strain: Isolate clinical 5A, Isolate
FT clinical 17A, Isolate clinical 21A, Isolate clinical 22A,
FT Isolate clinical 29A, Isolate clinical 30A, Isolate
FT clinical 33B, Isolate clinical 38A, Isolate clinical 44A,
FT Isolate clinical 47A, Isolate clinical 48A, clinical
FT Isolate 49A, Isolate clinical 56A and Isolate clinical
FT 79A)"
FT VARIANT 88
FT /note="D -> N (in strain: Isolate clinical 29A and Isolate
FT clinical 38A)"
FT VARIANT 92
FT /note="E -> G (in strain: Isolate clinical 17A, Isolate
FT clinical 21A and Isolate clinical 22A, Isolate clinical
FT 30A, Isolate clinical 33B, Isolate clinical 47A, Isolate
FT clinical 48A and Isolate clinical 79A)"
FT VARIANT 92
FT /note="E -> K (in strain: Isolate clinical 56A)"
FT VARIANT 93..95
FT /note="NQA -> EHT (in strain: Isolate clinical 5A, Isolate
FT clinical 17A, Isolate clinical 21A, Isolate clinical 22A,
FT Isolate clinical 29A, Isolate clinical 30A, Isolate
FT clinical 33B, Isolate clinical 38A, Isolate clinical 44A,
FT Isolate clinical 47A, Isolate clinical 48A, Isolate
FT clinical 49A, Isolate clinical 56A and Isolate clinical
FT 79A)"
FT VARIANT 93
FT /note="N -> D (in strain: Isolate clinical 8A)"
FT VARIANT 98..100
FT /note="NEK -> DDE (in strain: Isolate clinical 27A)"
FT VARIANT 99
FT /note="Missing (in strain: Isolate clinical 49A)"
FT VARIANT 101..102
FT /note="KI -> T (in strain: Isolate clinical 5A, Isolate
FT clinical 17A, Isolate clinical 21A, Isolate clinical 22A,
FT Isolate clinical 29A, Isolate clinical 30A, Isolate
FT clinical 33B, Isolate clinical 38A, Isolate clinical 44A,
FT Isolate clinical 47A, Isolate clinical 48A, Isolate
FT clinical 49A, Isolate clinical 56A and Isolate clinical
FT 79A)"
SQ SEQUENCE 103 AA; 11147 MW; 86941819BD83ECCD CRC64;
MARRLWILSL LAVTLTVALA APSQKSKRSV TVEQPSTSAD GSNTTPSKNV TLSQGGSTTD
GDEDYSGEYD VLITDGDGSE HQQPQKTDEH KENQAKENEK KIQ
