ID   UL23_HCMVA              Reviewed;         284 AA.
AC   P16846; Q7M6R0;
DT   01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 2.
DT   03-AUG-2022, entry version 58.
DE   RecName: Full=Tegument protein UL23;
GN   Name=UL23;
OS   Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Cytomegalovirus.
OX   NCBI_TaxID=10360;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=2161319; DOI=10.1007/978-3-642-74980-3_6;
RA   Chee M.S., Bankier A.T., Beck S., Bohni R., Brown C.M., Cerny R.,
RA   Horsnell T., Hutchison C.A. III, Kouzarides T., Martignetti J.A.,
RA   Preddie E., Satchwell S.C., Tomlinson P., Weston K.M., Barrell B.G.;
RT   "Analysis of the protein-coding content of the sequence of human
RT   cytomegalovirus strain AD169.";
RL   Curr. Top. Microbiol. Immunol. 154:125-169(1990).
RN   [2]
RP   GENOME REANNOTATION.
RX   PubMed=12533697; DOI=10.1099/vir.0.18606-0;
RA   Davison A.J., Dolan A., Akter P., Addison C., Dargan D.J., Alcendor D.J.,
RA   McGeoch D.J., Hayward G.S.;
RT   "The human cytomegalovirus genome revisited: comparison with the chimpanzee
RT   cytomegalovirus genome.";
RL   J. Gen. Virol. 84:17-28(2003).
RN   [3]
RP   ERRATUM OF PUBMED:12533697.
RA   Davison A.J., Dolan A., Akter P., Addison C., Dargan D.J., Alcendor D.J.,
RA   McGeoch D.J., Hayward G.S.;
RL   J. Gen. Virol. 84:1053-1053(2003).
RN   [4]
RP   SUBCELLULAR LOCATION.
RX   PubMed=12029146; DOI=10.1099/0022-1317-83-6-1315;
RA   Adair R., Douglas E.R., Maclean J.B., Graham S.Y., Aitken J.D.,
RA   Jamieson F.E., Dargan D.J.;
RT   "The products of human cytomegalovirus genes UL23, UL24, UL43 and US22 are
RT   tegument components.";
RL   J. Gen. Virol. 83:1315-1324(2002).
RN   [5]
RP   FUNCTION, INTERACTION WITH HOST NMI, AND SUBCELLULAR LOCATION.
RX   PubMed=29377960; DOI=10.1371/journal.ppat.1006867;
RA   Feng L., Sheng J., Vu G.P., Liu Y., Foo C., Wu S., Trang P.,
RA   Paliza-Carre M., Ran Y., Yang X., Sun X., Deng Z., Zhou T., Lu S., Li H.,
RA   Liu F.;
RT   "Human cytomegalovirus UL23 inhibits transcription of interferon-gamma
RT   stimulated genes and blocks antiviral interferon-gamma responses by
RT   interacting with human N-myc interactor protein.";
RL   PLoS Pathog. 14:e1006867-e1006867(2018).
RN   [6]
RP   FUNCTION.
RX   PubMed=34305856; DOI=10.3389/fmicb.2021.692515;
RA   Feng L., Li W., Wu X., Li X., Yang X., Ran Y., Wu J., Li H.;
RT   "Human Cytomegalovirus UL23 Attenuates Signal Transducer and Activator of
RT   Transcription 1 Phosphorylation and Type I Interferon Response.";
RL   Front. Microbiol. 12:692515-692515(2021).
CC   -!- FUNCTION: Plays a role in the inhibition of host innate immune response
CC       by disrupting the interaction between NMI and STAT1. In turn, NMI-
CC       mediated transcription of interferon-gamma stimulated genes is
CC       inhibited. {ECO:0000269|PubMed:29377960}.
CC   -!- SUBUNIT: Interacts with host NMI; this interaction inhibits NMI
CC       interaction with STAT1. {ECO:0000269|PubMed:29377960}.
CC   -!- SUBCELLULAR LOCATION: Virion tegument {ECO:0000269|PubMed:12029146}.
CC       Host cytoplasm {ECO:0000269|PubMed:29377960}.
CC   -!- SIMILARITY: Belongs to the herpesviridae US22 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAA35422.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; X17403; CAA35422.1; ALT_INIT; Genomic_DNA.
DR   EMBL; BK000394; DAA00127.1; -; Genomic_DNA.
DR   PIR; S09786; S09786.
DR   RefSeq; YP_081482.1; NC_006273.2.
DR   DNASU; 3077524; -.
DR   GeneID; 3077524; -.
DR   KEGG; vg:3077524; -.
DR   Proteomes; UP000008991; Genome.
DR   Proteomes; UP000008992; Genome.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0019033; C:viral tegument; IEA:UniProtKB-SubCell.
DR   GO; GO:0039563; P:suppression by virus of host JAK-STAT cascade via inhibition of STAT1 activity; IEA:UniProtKB-KW.
DR   GO; GO:0039502; P:suppression by virus of host type I interferon-mediated signaling pathway; IEA:UniProtKB-KW.
DR   InterPro; IPR003360; US22-like.
DR   Pfam; PF02393; US22; 1.
PE   1: Evidence at protein level;
KW   Host cytoplasm; Host-virus interaction;
KW   Inhibition of host innate immune response by virus;
KW   Inhibition of host interferon signaling pathway by virus;
KW   Inhibition of host STAT1 by virus; Reference proteome; Viral immunoevasion;
KW   Virion; Virion tegument.
FT   CHAIN           1..284
FT                   /note="Tegument protein UL23"
FT                   /id="PRO_0000116304"
SQ   SEQUENCE   284 AA;  32957 MW;  FE02F65EC1CF22AC CRC64;
     MSVIKDCFLN LLDRWRPPKT SRPWKPGQRV ALVWPKDRCL VIRRRWRLVR DEGRDAQRLA
     SYLCCPEPLR FVGSICTYNF LKHKGDHNVP SELYLGASGA MYLWTDHIYS DSLTFVAESI
     TEFLNIGLRR CNFITVPEEL PHTASLRALA GCMHIHAFAQ WRATYRGRLM VMGDYSVIRV
     STIRLYDWSE INDWRVMVGS NHVEPLGWLV SPYDVINLFV DDCMRVFAAN NQHVCIVADS
     LMEFVTRGMT RCHENGIYYG TRSMRKLNKP TCPYGVDHQL FDDA