ID   UL23_HCMVM              Reviewed;         284 AA.
AC   F5HDM3;
DT   18-APR-2012, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   23-FEB-2022, entry version 24.
DE   RecName: Full=Tegument protein UL23;
GN   Name=UL23;
OS   Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Cytomegalovirus.
OX   NCBI_TaxID=295027;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Merlin;
RX   PubMed=15105547; DOI=10.1099/vir.0.79888-0;
RA   Dolan A., Cunningham C., Hector R.D., Hassan-Walker A.F., Lee L.,
RA   Addison C., Dargan D.J., McGeoch D.J., Gatherer D., Emery V.C.,
RA   Griffiths P.D., Sinzger C., McSharry B.P., Wilkinson G.W.G., Davison A.J.;
RT   "Genetic content of wild-type human cytomegalovirus.";
RL   J. Gen. Virol. 85:1301-1312(2004).
CC   -!- FUNCTION: Plays a role in the inhibition of host innate immune response
CC       by disrupting the interaction between NMI and STAT1. In turn, NMI-
CC       mediated transcription of interferon-gamma stimulated genes is
CC       inhibited. {ECO:0000250|UniProtKB:P16846}.
CC   -!- SUBUNIT: Interacts with host NMI; this interaction inhibits NMI
CC       interaction with STAT1. {ECO:0000250|UniProtKB:P16846}.
CC   -!- SUBCELLULAR LOCATION: Virion tegument {ECO:0000250|UniProtKB:P16846}.
CC       Host cytoplasm {ECO:0000250|UniProtKB:P16846}.
CC   -!- SIMILARITY: Belongs to the herpesviridae US22 family. {ECO:0000305}.
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DR   EMBL; AY446894; AAR31588.1; -; Genomic_DNA.
DR   RefSeq; YP_081482.1; NC_006273.2.
DR   PRIDE; F5HDM3; -.
DR   DNASU; 3077524; -.
DR   GeneID; 3077524; -.
DR   KEGG; vg:3077524; -.
DR   Reactome; R-HSA-9609690; HCMV Early Events.
DR   Reactome; R-HSA-9610379; HCMV Late Events.
DR   Proteomes; UP000000938; Genome.
DR   GO; GO:0072517; C:host cell viral assembly compartment; TAS:Reactome.
DR   GO; GO:0019033; C:viral tegument; TAS:Reactome.
DR   InterPro; IPR003360; US22-like.
DR   Pfam; PF02393; US22; 1.
PE   3: Inferred from homology;
KW   Host cytoplasm; Reference proteome; Virion; Virion tegument.
FT   CHAIN           1..284
FT                   /note="Tegument protein UL23"
FT                   /id="PRO_0000416715"
SQ   SEQUENCE   284 AA;  32957 MW;  FE02F65EC1CF22AC CRC64;
     MSVIKDCFLN LLDRWRPPKT SRPWKPGQRV ALVWPKDRCL VIRRRWRLVR DEGRDAQRLA
     SYLCCPEPLR FVGSICTYNF LKHKGDHNVP SELYLGASGA MYLWTDHIYS DSLTFVAESI
     TEFLNIGLRR CNFITVPEEL PHTASLRALA GCMHIHAFAQ WRATYRGRLM VMGDYSVIRV
     STIRLYDWSE INDWRVMVGS NHVEPLGWLV SPYDVINLFV DDCMRVFAAN NQHVCIVADS
     LMEFVTRGMT RCHENGIYYG TRSMRKLNKP TCPYGVDHQL FDDA