ID   CA14_CONSE              Reviewed;          17 AA.
AC   P0DPM2;
DT   12-SEP-2018, integrated into UniProtKB/Swiss-Prot.
DT   12-SEP-2018, sequence version 1.
DT   25-MAY-2022, entry version 8.
DE   RecName: Full=Alpha-conotoxin-like Sm1.4 {ECO:0000305};
DE   Flags: Precursor;
OS   Conus stercusmuscarum (Fly-specked cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Pionoconus.
OX   NCBI_TaxID=89452;
RN   [1]
RP   PROTEIN SEQUENCE, IDENTIFICATION BY MASS SPECTROMETRY, SUBCELLULAR
RP   LOCATION, OXIDATION AT MET-2, AND AMIDATION AT CYS-17.
RC   TISSUE=Venom;
RX   PubMed=22709442; DOI=10.1021/pr300312h;
RA   Bhatia S., Kil Y.J., Ueberheide B., Chait B.T., Tayo L., Cruz L., Lu B.,
RA   Yates J.R. III, Bern M.;
RT   "Constrained de novo sequencing of conotoxins.";
RL   J. Proteome Res. 11:4191-4200(2012).
CC   -!- FUNCTION: Alpha-conotoxins act on postsynaptic membranes, they bind to
CC       the nicotinic acetylcholine receptors (nAChR) and thus inhibit them.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:22709442}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC       {ECO:0000305|PubMed:22709442}.
CC   -!- DOMAIN: The cysteine framework is I (CC-C-C). Alpha3/5 pattern.
CC       {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the conotoxin A superfamily. {ECO:0000305}.
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DR   AlphaFoldDB; P0DPM2; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0035792; C:host cell postsynaptic membrane; IEA:UniProtKB-KW.
DR   GO; GO:0030550; F:acetylcholine receptor inhibitor activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Acetylcholine receptor inhibiting toxin; Amidation;
KW   Direct protein sequencing; Disulfide bond; Neurotoxin; Oxidation;
KW   Postsynaptic neurotoxin; Secreted; Toxin.
FT   PEPTIDE         1..17
FT                   /note="Alpha-conotoxin-like Sm1.4"
FT                   /evidence="ECO:0000305|PubMed:22709442"
FT                   /id="PRO_0000445062"
FT   MOD_RES         2
FT                   /note="Methionine sulfoxide; partial"
FT                   /evidence="ECO:0000269|PubMed:22709442"
FT   MOD_RES         17
FT                   /note="Cysteine amide; partial"
FT                   /evidence="ECO:0000269|PubMed:22709442"
FT   DISULFID        5..10
FT                   /evidence="ECO:0000250|UniProtKB:P01519"
FT   DISULFID        6..17
FT                   /evidence="ECO:0000250|UniProtKB:P01519"
FT   UNSURE          1
FT                   /note="I or L"
FT                   /evidence="ECO:0000305|PubMed:22709442"
SQ   SEQUENCE   17 AA;  1806 MW;  DFC025EC66837F9C CRC64;
     IMYDCCSGSC SGYTGRC