ID   UL24_HHV11              Reviewed;         269 AA.
AC   P10208; B9VQF1; Q09IA9;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1989, sequence version 1.
DT   29-SEP-2021, entry version 67.
DE   RecName: Full=Protein UL24;
GN   ORFNames=UL24;
OS   Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Alphaherpesvirinae; Simplexvirus.
OX   NCBI_TaxID=10299;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=2839594; DOI=10.1099/0022-1317-69-7-1531;
RA   McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C., McNab D.,
RA   Perry L.J., Scott J.E., Taylor P.;
RT   "The complete DNA sequence of the long unique region in the genome of
RT   herpes simplex virus type 1.";
RL   J. Gen. Virol. 69:1531-1574(1988).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Nonneuroinvasive mutant HF10;
RX   PubMed=17218138; DOI=10.1016/j.micinf.2006.10.019;
RA   Ushijima Y., Luo C., Goshima F., Yamauchi Y., Kimura H., Nishiyama Y.;
RT   "Determination and analysis of the DNA sequence of highly attenuated herpes
RT   simplex virus type 1 mutant HF10, a potential oncolytic virus.";
RL   Microbes Infect. 9:142-149(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=17 syn+;
RA   Cunningham C., Davison A.J.;
RT   "Herpes simplex virus type 1 bacterial artificial chromosome.";
RL   Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   FUNCTION, AND SUBCELLULAR LOCATION.
RX   PubMed=18420791; DOI=10.1099/vir.0.83573-0;
RA   Bertrand L., Pearson A.;
RT   "The conserved N-terminal domain of herpes simplex virus 1 UL24 protein is
RT   sufficient to induce the spatial redistribution of nucleolin.";
RL   J. Gen. Virol. 89:1142-1151(2008).
RN   [5]
RP   FUNCTION, AND MUTAGENESIS OF 99-ASP--LYS-101.
RX   PubMed=19864385; DOI=10.1128/jvi.01428-09;
RA   Bertrand L., Leiva-Torres G.A., Hyjazie H., Pearson A.;
RT   "Conserved residues in the UL24 protein of herpes simplex virus 1 are
RT   important for dispersal of the nucleolar protein nucleolin.";
RL   J. Virol. 84:109-118(2010).
RN   [6]
RP   FUNCTION, AND MUTAGENESIS OF 99-ASP--LYS-101.
RC   STRAIN=KOS;
RX   PubMed=21316727; DOI=10.1016/j.virol.2011.01.016;
RA   Lymberopoulos M.H., Bourget A., Abdeljelil N.B., Pearson A.;
RT   "Involvement of the UL24 protein in herpes simplex virus 1-induced
RT   dispersal of B23 and in nuclear egress.";
RL   Virology 412:341-348(2011).
CC   -!- FUNCTION: May participate in nuclear egress of viral particles. Plays a
CC       role in the dispersal of several host nucleolar proteins including
CC       NCL/nucleolin and NPM1. Since deletion of host NCL/nucleolin negatively
CC       impact on nuclear egress, UL24 supposedly acts on this process through
CC       its effect on host nucleoli. {ECO:0000269|PubMed:18420791,
CC       ECO:0000269|PubMed:19864385, ECO:0000269|PubMed:21316727}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000250}. Host cytoplasm
CC       {ECO:0000269|PubMed:18420791}. Host nucleus, host nucleolus
CC       {ECO:0000269|PubMed:18420791}. Host Golgi apparatus
CC       {ECO:0000269|PubMed:18420791}.
CC   -!- INDUCTION: Expressed late in the infection cycle.
CC   -!- SIMILARITY: Belongs to the herpesviridae UL24 family. {ECO:0000305}.
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DR   EMBL; X14112; CAA32316.1; -; Genomic_DNA.
DR   EMBL; DQ889502; ABI63486.1; -; Genomic_DNA.
DR   EMBL; FJ593289; ACM62246.1; -; Genomic_DNA.
DR   PIR; F30084; WMBEW4.
DR   RefSeq; YP_009137098.1; NC_001806.2.
DR   BioGRID; 971416; 1.
DR   PRIDE; P10208; -.
DR   GeneID; 24271468; -.
DR   KEGG; vg:24271468; -.
DR   Proteomes; UP000009294; Genome.
DR   Proteomes; UP000180652; Genome.
DR   GO; GO:0044177; C:host cell Golgi apparatus; IEA:UniProtKB-SubCell.
DR   GO; GO:0044196; C:host cell nucleolus; IEA:UniProtKB-SubCell.
DR   InterPro; IPR002580; Herpes_UL24.
DR   Pfam; PF01646; Herpes_UL24; 1.
PE   1: Evidence at protein level;
KW   Host cytoplasm; Host Golgi apparatus; Host nucleus; Reference proteome;
KW   Virion.
FT   CHAIN           1..269
FT                   /note="Protein UL24"
FT                   /id="PRO_0000115978"
FT   REGION          191..244
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VARIANT         191
FT                   /note="I -> M (in strain: Nonneuroinvasive mutant HF10)"
FT   VARIANT         226
FT                   /note="S -> P (in strain: Nonneuroinvasive mutant HF10)"
FT   VARIANT         239
FT                   /note="T -> A (in strain: Nonneuroinvasive mutant HF10 and
FT                   17 syn+)"
FT   MUTAGEN         99..101
FT                   /note="ELK->ALA: Loss of about 75% of host NPM1 and 80% of
FT                   host NCL dispersal."
FT                   /evidence="ECO:0000269|PubMed:19864385,
FT                   ECO:0000269|PubMed:21316727"
SQ   SEQUENCE   269 AA;  29476 MW;  CB089B7D72B09427 CRC64;
     MAARTRSLVE RRRVLMAGVR SHTRFYKALA EEVREFHATK ICGTLLTLLS GSLQGRSVFE
     ATRVTLICEV DLGPRRPDCI CVFEFANDKT LGGVCVIIEL KTCKYISSGD TASKREQRAT
     GMKQLRHSLK LLQSLAPPGD KIVYLCPVLV FVAQRTLRVS RVTRLVPQKV SGNITAVVRM
     LQSLSTYTVP IEPRTQRARR RRGGAARGSA SRPKRSHSGA RDPPESAARQ LPPADQTPTS
     TEGGGVLKRI AALFCVPVAT KTKPRAASE