ID   UL24_HHV2H              Reviewed;         281 AA.
AC   P89447;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1997, sequence version 1.
DT   23-FEB-2022, entry version 63.
DE   RecName: Full=Protein UL24;
GN   ORFNames=UL24;
OS   Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Alphaherpesvirinae; Simplexvirus.
OX   NCBI_TaxID=10315;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=9499055; DOI=10.1128/jvi.72.3.2010-2021.1998;
RA   Dolan A., Jamieson F.E., Cunningham C., Barnett B.C., McGeoch D.J.;
RT   "The genome sequence of herpes simplex virus type 2.";
RL   J. Virol. 72:2010-2021(1998).
RN   [2]
RP   SUBCELLULAR LOCATION, AND LATE PROTEIN.
RC   STRAIN=186;
RX   PubMed=11450950; DOI=10.1023/a:1011118424474;
RA   Hong-Yan Z., Murata T., Goshima F., Takakuwa H., Koshizuka T., Yamauchi Y.,
RA   Nishiyama Y.;
RT   "Identification and characterization of the UL24 gene product of herpes
RT   simplex virus type 2.";
RL   Virus Genes 22:321-327(2001).
CC   -!- FUNCTION: May participate in nuclear egress of viral particles. Plays a
CC       role in the dispersal of several host nucleolar proteins including
CC       NCL/nucleolin and NPM1. Since deletion of host NCL/nucleolin negatively
CC       impact on nuclear egress, UL24 supposedly acts on this process through
CC       its effect on host nucleoli (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000269|PubMed:11450950}. Host
CC       cytoplasm {ECO:0000269|PubMed:11450950}. Host nucleus, host nucleolus
CC       {ECO:0000269|PubMed:11450950}. Host Golgi apparatus
CC       {ECO:0000269|PubMed:11450950}.
CC   -!- INDUCTION: Expressed late in the infection cycle.
CC   -!- SIMILARITY: Belongs to the herpesviridae UL24 family. {ECO:0000305}.
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DR   EMBL; Z86099; CAB06748.1; -; Genomic_DNA.
DR   RefSeq; YP_009137175.1; NC_001798.2.
DR   PRIDE; P89447; -.
DR   DNASU; 1487308; -.
DR   GeneID; 1487308; -.
DR   KEGG; vg:1487308; -.
DR   Proteomes; UP000001874; Genome.
DR   GO; GO:0044177; C:host cell Golgi apparatus; IEA:UniProtKB-SubCell.
DR   GO; GO:0044196; C:host cell nucleolus; IEA:UniProtKB-SubCell.
DR   InterPro; IPR002580; Herpes_UL24.
DR   Pfam; PF01646; Herpes_UL24; 1.
PE   2: Evidence at transcript level;
KW   Host cytoplasm; Host Golgi apparatus; Host nucleus; Late protein;
KW   Reference proteome; Virion.
FT   CHAIN           1..281
FT                   /note="Protein UL24"
FT                   /id="PRO_0000385155"
FT   REGION          199..252
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   281 AA;  30547 MW;  1D46891FDDA4F210 CRC64;
     MARTGRRAAV GRPARTSSLT ERRRVLLAGV RSHTRFYKAF AREVREFNAT RICGTLLTLM
     SGSLQGRSLF EATRVTLICE VDLGPRRPDC ICVFEFANDK TLGGVCVILE LKTCKSISSG
     DTASKREQRT TGMKQLRHSL KLLQSLAPPG DKVVYLCPIL VFVAQRTLRV SRVTRLVPQK
     ISGNITAAVR MLQSLSTYAV PPEPQTRRSR RRVAATARPQ RPPSPTRDPE GTAGHPAPPE
     SDPPSPGVVG VAAEGGGVLQ KIAALFCVPV AAKSRPRTKT E