ID   UL24_HHV6G              Reviewed;         252 AA.
AC   P52535;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   23-FEB-2022, entry version 43.
DE   RecName: Full=Protein UL24 homolog;
GN   Name=U49; Synonyms=LF2;
OS   Human herpesvirus 6A (strain GS) (HHV-6 variant A) (Human B lymphotropic
OS   virus).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Roseolovirus.
OX   NCBI_TaxID=10369;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1654455; DOI=10.1128/jvi.65.10.5597-5604.1991;
RA   Josephs S.F., Ablashi D.V., Salahuddin S.Z., Jagodzinski L.L.,
RA   Wong-Staal F., Gallo R.C.;
RT   "Identification of the human herpesvirus 6 glycoprotein H and putative
RT   large tegument protein genes.";
RL   J. Virol. 65:5597-5604(1991).
CC   -!- FUNCTION: May participate in nuclear egress of viral particles. Plays a
CC       role in the dispersal of several host nucleolar proteins including
CC       NCL/nucleolin and NPM1. Since deletion of host NCL/nucleolin negatively
CC       impact on nuclear egress, UL24 supposedly acts on this process through
CC       its effect on host nucleoli (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000250}. Host cytoplasm
CC       {ECO:0000250}. Host nucleus, host nucleolus {ECO:0000250}. Host Golgi
CC       apparatus {ECO:0000250}.
CC   -!- INDUCTION: Expressed late in the infection cycle.
CC   -!- SIMILARITY: Belongs to the herpesviridae UL24 family. {ECO:0000305}.
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DR   EMBL; S57509; AAB19778.1; -; Genomic_DNA.
DR   GO; GO:0044177; C:host cell Golgi apparatus; IEA:UniProtKB-SubCell.
DR   GO; GO:0044196; C:host cell nucleolus; IEA:UniProtKB-SubCell.
DR   InterPro; IPR002580; Herpes_UL24.
DR   Pfam; PF01646; Herpes_UL24; 1.
PE   2: Evidence at transcript level;
KW   Host cytoplasm; Host Golgi apparatus; Host nucleus; Late protein; Virion.
FT   CHAIN           1..252
FT                   /note="Protein UL24 homolog"
FT                   /id="PRO_0000115984"
FT   REGION          215..252
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        217..233
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        236..252
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   252 AA;  29354 MW;  2A90C9D686EA4E96 CRC64;
     MSLTGLPDIR KKIGQFHHLR IYKQILSFQG NFARLNYFLG DVFPANLRSA SVSVFFEVRL
     GPRIPDCIVL LKSVDVKDEF AFHCYFFEFK TTLGKSTMQS VHHNCIHQAQ YLQGLRQLQQ
     SISFLDQYLI ADEVSWNVVP VICFFRQWGL KLDFFKKFSG KTKRLSFSFI RDLFARSQDG
     AVQSLLSIPN YTNFRRACQK HTDLYRKRCR KAPKSVLTKT SGENRSRASR QVAKNAPKNR
     IRRTAKKDAK RQ