ID   UL24_HHV6U              Reviewed;         252 AA.
AC   Q06092;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   23-FEB-2022, entry version 59.
DE   RecName: Full=Protein UL24 homolog;
GN   Name=U49; Synonyms=BHRF2;
OS   Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B
OS   lymphotropic virus).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Roseolovirus.
OX   NCBI_TaxID=10370;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1333836; DOI=10.3109/10425179209039693;
RA   Gompels U.A., Carss A.L., Sun N., Arrand J.R.;
RT   "Infectivity determinants encoded in a conserved gene block of human
RT   herpesvirus-6.";
RL   DNA Seq. 3:25-39(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=7747482; DOI=10.1006/viro.1995.1228;
RA   Gompels U.A., Nicholas J., Lawrence G.L., Jones M., Thomson B.J.,
RA   Martin M.E.D., Efstathiou S., Craxton M.A., Macaulay H.A.;
RT   "The DNA sequence of human herpesvirus-6: structure, coding content, and
RT   genome evolution.";
RL   Virology 209:29-51(1995).
CC   -!- FUNCTION: May participate in nuclear egress of viral particles. Plays a
CC       role in the dispersal of several host nucleolar proteins including
CC       NCL/nucleolin and NPM1. Since deletion of host NCL/nucleolin negatively
CC       impact on nuclear egress, UL24 supposedly acts on this process through
CC       its effect on host nucleoli (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000250}. Host cytoplasm
CC       {ECO:0000250}. Host nucleus, host nucleolus {ECO:0000250}. Host Golgi
CC       apparatus {ECO:0000250}.
CC   -!- INDUCTION: Expressed late in the infection cycle.
CC   -!- SIMILARITY: Belongs to the herpesviridae UL24 family. {ECO:0000305}.
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DR   EMBL; X64320; CAA45604.1; -; Genomic_DNA.
DR   EMBL; X83413; CAA58383.1; -; Genomic_DNA.
DR   PIR; E56653; E56653.
DR   RefSeq; NP_042942.1; NC_001664.2.
DR   PRIDE; Q06092; -.
DR   DNASU; 1487929; -.
DR   GeneID; 1487929; -.
DR   KEGG; vg:1487929; -.
DR   Proteomes; UP000009295; Genome.
DR   GO; GO:0044177; C:host cell Golgi apparatus; IEA:UniProtKB-SubCell.
DR   GO; GO:0044196; C:host cell nucleolus; IEA:UniProtKB-SubCell.
DR   InterPro; IPR002580; Herpes_UL24.
DR   Pfam; PF01646; Herpes_UL24; 1.
PE   2: Evidence at transcript level;
KW   Host cytoplasm; Host Golgi apparatus; Host nucleus; Late protein;
KW   Reference proteome; Virion.
FT   CHAIN           1..252
FT                   /note="Protein UL24 homolog"
FT                   /id="PRO_0000115985"
FT   REGION          215..252
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        217..233
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        236..252
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   252 AA;  29292 MW;  5827B992FBC0C927 CRC64;
     MSLTGLPDIR KKIGQFHHLR IYKQILSLQG NFARLNYFLG DVFPANLRSA SVSVFFEVRL
     GPRIPDCIVL LKSVDAKDEF AFHCYFFEFK TTLGKSTMQS VHHNCIHQAQ YLQGLRQLQQ
     SISFLDQYLI ADEVSWNVVP VICFFRQWGL KLDFFKKFSG KTKRLSFSFI RDLFARSQDG
     AVQSLLSIPN YTNFRRACQK HTDLYRKRCR KAPKSVLTKT SGENRSRASR QVAKNAPKNR
     IRRTAKKDAK RQ