ID   UL24_HHV8P              Reviewed;         257 AA.
AC   Q2HRB2;
DT   16-OCT-2013, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2006, sequence version 1.
DT   29-SEP-2021, entry version 46.
DE   RecName: Full=Protein UL24 homolog;
GN   Name=ORF20;
OS   Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's
OS   sarcoma-associated herpesvirus).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Gammaherpesvirinae; Rhadinovirus.
OX   NCBI_TaxID=868565;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=10400794; DOI=10.1128/jvi.73.8.6953-6963.1999;
RA   Glenn M., Rainbow L., Aurade F., Davison A., Schulz T.F.;
RT   "Identification of a spliced gene from Kaposi's sarcoma-associated
RT   herpesvirus encoding a protein with similarities to latent membrane
RT   proteins 1 and 2A of Epstein-Barr virus.";
RL   J. Virol. 73:6953-6963(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16760382; DOI=10.1099/vir.0.81919-0;
RA   Rezaee S.A.R., Cunningham C., Davison A.J., Blackbourn D.J.;
RT   "Kaposi's sarcoma-associated herpesvirus immune modulation: an overview.";
RL   J. Gen. Virol. 87:1781-1804(2006).
RN   [3]
RP   FUNCTION.
RX   PubMed=19526192; DOI=10.1007/s00705-009-0420-y;
RA   Nascimento R., Dias J.D., Parkhouse R.M.;
RT   "The conserved UL24 family of human alpha, beta and gamma herpesviruses
RT   induces cell cycle arrest and inactivation of the cyclinB/cdc2 complex.";
RL   Arch. Virol. 154:1143-1149(2009).
CC   -!- FUNCTION: May participate in nuclear egress of viral particles. Plays a
CC       role in the dispersal of several host nucleolar proteins including
CC       NCL/nucleolin and NPM1. Since deletion of host NCL/nucleolin negatively
CC       impact on nuclear egress, UL24 supposedly acts on this process through
CC       its effect on host nucleoli (By similarity). Induces cell cycle arrest
CC       in host cells at the G2/M phase following by apoptosis. The mechanism
CC       involves the inhibition of host mitotic complex cyclin-B/CDK1.
CC       {ECO:0000250, ECO:0000269|PubMed:19526192}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000250}. Host cytoplasm
CC       {ECO:0000250}. Host nucleus, host nucleolus {ECO:0000250}. Host Golgi
CC       apparatus {ECO:0000250}.
CC   -!- INDUCTION: Expressed late in the infection cycle.
CC   -!- SIMILARITY: Belongs to the herpesviridae UL24 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AF148805; ABD28871.1; -; Genomic_DNA.
DR   RefSeq; YP_001129373.1; NC_009333.1.
DR   BioGRID; 1776980; 1.
DR   BindingDB; Q2HRB2; -.
DR   PRIDE; Q2HRB2; -.
DR   DNASU; 4961477; -.
DR   GeneID; 4961477; -.
DR   KEGG; vg:4961477; -.
DR   Proteomes; UP000000942; Genome.
DR   GO; GO:0044177; C:host cell Golgi apparatus; IEA:UniProtKB-SubCell.
DR   GO; GO:0044196; C:host cell nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0039592; P:suppression by virus of G2/M transition of host mitotic cell cycle; IEA:UniProtKB-KW.
DR   InterPro; IPR002580; Herpes_UL24.
DR   Pfam; PF01646; Herpes_UL24; 1.
PE   2: Evidence at transcript level;
KW   Host cytoplasm; Host G2/M cell cycle arrest by virus; Host Golgi apparatus;
KW   Host nucleus; Host-virus interaction;
KW   Modulation of host cell cycle by virus; Reference proteome; Virion.
FT   CHAIN           1..257
FT                   /note="Protein UL24 homolog"
FT                   /id="PRO_0000423765"
FT   REGION          193..257
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   257 AA;  28413 MW;  D2D4C4941598408F CRC64;
     MVRPTEAEVK KSLSRLPAAR KRAGNRAHLA TYRRLLKYST LPDLWRFLSS RPQNPPLGHH
     RLFFEVTLGH RIADCVILVS GGHQPVCYVV ELKTCLSHQL IPTNTVRTSQ RAQGLCQLSD
     SIHYIAHSAP PGTEAWTITP LLIFKNQKTL KTVYSESPGA FPTPVHTTEG KLCAFLTARE
     NADIRKVLSK VPKKPKMDRG GKILGPTPGK RAVYSQAHHG RNKKGRPWTA QPTRAKSRTK
     DKGTPAFPRA GPACSGP