CA159_HUMAN
ID CA159_HUMAN Reviewed; 380 AA.
AC Q96HA4; B3KQ46; Q5T2W6; Q6UX67; Q6ZR77; Q9NWV0;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 31-OCT-2006, sequence version 2.
DT 03-AUG-2022, entry version 136.
DE RecName: Full=Uncharacterized protein C1orf159;
DE Flags: Precursor;
GN Name=C1orf159; ORFNames=UNQ2998/PRO9739;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 5 AND 4).
RC TISSUE=Carcinoma, Testis, and Thymus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Uterus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q96HA4-2; P02786: TFRC; NbExp=3; IntAct=EBI-17586094, EBI-355727;
CC Q96HA4-2; Q96B49: TOMM6; NbExp=3; IntAct=EBI-17586094, EBI-10826510;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=5;
CC Name=1;
CC IsoId=Q96HA4-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q96HA4-2; Sequence=VSP_021281, VSP_021282, VSP_021285;
CC Name=3;
CC IsoId=Q96HA4-3; Sequence=VSP_021281, VSP_021284, VSP_021286;
CC Name=4;
CC IsoId=Q96HA4-4; Sequence=VSP_021281, VSP_021283;
CC Name=5;
CC IsoId=Q96HA4-5; Sequence=VSP_021280;
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DR EMBL; AY358490; AAQ88854.1; -; mRNA.
DR EMBL; AK000591; BAA91276.1; -; mRNA.
DR EMBL; AK057368; BAG51908.1; -; mRNA.
DR EMBL; AK128434; BAC87438.1; -; mRNA.
DR EMBL; AL390719; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC008788; AAH08788.1; -; mRNA.
DR CCDS; CCDS7.2; -. [Q96HA4-4]
DR CCDS; CCDS81250.1; -. [Q96HA4-1]
DR RefSeq; NP_001317235.1; NM_001330306.1. [Q96HA4-1]
DR RefSeq; NP_060361.4; NM_017891.4. [Q96HA4-4]
DR RefSeq; XP_011539963.1; XM_011541661.2.
DR RefSeq; XP_011539964.1; XM_011541662.2.
DR RefSeq; XP_016857065.1; XM_017001576.1.
DR AlphaFoldDB; Q96HA4; -.
DR BioGRID; 120325; 11.
DR IntAct; Q96HA4; 8.
DR GlyGen; Q96HA4; 4 sites.
DR iPTMnet; Q96HA4; -.
DR PhosphoSitePlus; Q96HA4; -.
DR BioMuta; C1orf159; -.
DR DMDM; 119371554; -.
DR EPD; Q96HA4; -.
DR MassIVE; Q96HA4; -.
DR MaxQB; Q96HA4; -.
DR PaxDb; Q96HA4; -.
DR PeptideAtlas; Q96HA4; -.
DR PRIDE; Q96HA4; -.
DR ProteomicsDB; 76718; -. [Q96HA4-1]
DR ProteomicsDB; 76719; -. [Q96HA4-2]
DR ProteomicsDB; 76720; -. [Q96HA4-3]
DR ProteomicsDB; 76721; -. [Q96HA4-4]
DR ProteomicsDB; 76722; -. [Q96HA4-5]
DR Antibodypedia; 2435; 111 antibodies from 13 providers.
DR DNASU; 54991; -.
DR Ensembl; ENST00000379319.5; ENSP00000368623.1; ENSG00000131591.18. [Q96HA4-4]
DR Ensembl; ENST00000379325.7; ENSP00000368629.3; ENSG00000131591.18. [Q96HA4-3]
DR Ensembl; ENST00000379339.5; ENSP00000368644.1; ENSG00000131591.18. [Q96HA4-1]
DR Ensembl; ENST00000421241.7; ENSP00000400736.2; ENSG00000131591.18. [Q96HA4-4]
DR GeneID; 54991; -.
DR KEGG; hsa:54991; -.
DR MANE-Select; ENST00000421241.7; ENSP00000400736.2; NM_017891.5; NP_060361.4. [Q96HA4-4]
DR UCSC; uc001act.3; human. [Q96HA4-1]
DR CTD; 54991; -.
DR GeneCards; C1orf159; -.
DR HGNC; HGNC:26062; C1orf159.
DR HPA; ENSG00000131591; Tissue enhanced (testis).
DR neXtProt; NX_Q96HA4; -.
DR OpenTargets; ENSG00000131591; -.
DR PharmGKB; PA142672410; -.
DR VEuPathDB; HostDB:ENSG00000131591; -.
DR GeneTree; ENSGT00390000009794; -.
DR HOGENOM; CLU_069381_1_0_1; -.
DR InParanoid; Q96HA4; -.
DR OMA; RLPGIFY; -.
DR OrthoDB; 1286818at2759; -.
DR PhylomeDB; Q96HA4; -.
DR TreeFam; TF330740; -.
DR PathwayCommons; Q96HA4; -.
DR SignaLink; Q96HA4; -.
DR BioGRID-ORCS; 54991; 14 hits in 1069 CRISPR screens.
DR ChiTaRS; C1orf159; human.
DR GenomeRNAi; 54991; -.
DR Pharos; Q96HA4; Tdark.
DR PRO; PR:Q96HA4; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q96HA4; protein.
DR Bgee; ENSG00000131591; Expressed in left testis and 96 other tissues.
DR ExpressionAtlas; Q96HA4; baseline and differential.
DR Genevisible; Q96HA4; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR027888; DUF4501.
DR PANTHER; PTHR16247; PTHR16247; 1.
DR Pfam; PF14946; DUF4501; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Glycoprotein; Membrane; Reference proteome; Signal;
KW Transmembrane; Transmembrane helix.
FT SIGNAL 1..18
FT /evidence="ECO:0000255"
FT CHAIN 19..380
FT /note="Uncharacterized protein C1orf159"
FT /id="PRO_0000255250"
FT TRANSMEM 148..168
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 229..256
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 336..380
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 104
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 111
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 128
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 1..126
FT /note="Missing (in isoform 5)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_021280"
FT VAR_SEQ 25..60
FT /note="Missing (in isoform 2, isoform 3 and isoform 4)"
FT /evidence="ECO:0000303|PubMed:12975309,
FT ECO:0000303|PubMed:14702039, ECO:0000303|PubMed:15489334"
FT /id="VSP_021281"
FT VAR_SEQ 185..221
FT /note="APALQPGEAAAMIPPPQSSGNSSCRIPLWGFPSLGQS -> GPAPAGSLPGR
FT WSSQQFGPQAPALQPGEAVSNPHHPG (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_021282"
FT VAR_SEQ 204..349
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_021283"
FT VAR_SEQ 204..225
FT /note="GNSSCRIPLWGFPSLGQSQGAL -> DVGSAGKEDPPRQGRPPIPAPP (in
FT isoform 3)"
FT /evidence="ECO:0000303|PubMed:12975309"
FT /id="VSP_021284"
FT VAR_SEQ 222..380
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_021285"
FT VAR_SEQ 226..380
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:12975309"
FT /id="VSP_021286"
SQ SEQUENCE 380 AA; 40283 MW; D82F85CF3D903B81 CRC64;
MALRHLALLA GLLVGVASKS MENTVTRNST AVINTQAEGT LSPPGLSSLP VVREWALTHT
AQLPECCVDV VGVNASCPGA SLCGPGCYRR WNADGSASCV RCGNGTLPAY NGSECRSFAG
PGAPFPMNRS SGTPGRPHPG APRVAASLFL GTFFISSGLI LSVAGFFYLK RSSKLPRACY
RRNKAPALQP GEAAAMIPPP QSSGNSSCRI PLWGFPSLGQ SQGALWVCPQ TGLPGSGSRP
PLPGSPGDPP TRQGQGRIWL VPPALDLSWI WPAPPARPPL IPVTSMLFPV PETWGLQERR
THHDRADPQY LLLLEVQLHP RTDAAGLRQA LLSSHRFSGA GSGGPKSQPV RKPRYVRRER
PLDRATDPAA FPGEARISNV
