ID   UL24_VZVD               Reviewed;         258 AA.
AC   P09288;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1989, sequence version 1.
DT   29-SEP-2021, entry version 58.
DE   RecName: Full=Protein UL24 homolog;
GN   ORFNames=ORF35;
OS   Varicella-zoster virus (strain Dumas) (HHV-3) (Human herpesvirus 3).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Alphaherpesvirinae; Varicellovirus.
OX   NCBI_TaxID=10338;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=3018124; DOI=10.1099/0022-1317-67-9-1759;
RA   Davison A.J., Scott J.E.;
RT   "The complete DNA sequence of varicella-zoster virus.";
RL   J. Gen. Virol. 67:1759-1816(1986).
CC   -!- FUNCTION: May participate in nuclear egress of viral particles. Plays a
CC       role in the dispersal of several host nucleolar proteins including
CC       NCL/nucleolin and NPM1. Since deletion of host NCL/nucleolin negatively
CC       impact on nuclear egress, UL24 supposedly acts on this process through
CC       its effect on host nucleoli (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000250}. Host cytoplasm
CC       {ECO:0000250}. Host nucleus, host nucleolus {ECO:0000250}. Host Golgi
CC       apparatus {ECO:0000250}.
CC   -!- INDUCTION: Expressed late in the infection cycle.
CC   -!- SIMILARITY: Belongs to the herpesviridae UL24 family. {ECO:0000305}.
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DR   EMBL; X04370; CAA27918.1; -; Genomic_DNA.
DR   PIR; I27214; WZBE35.
DR   PRIDE; P09288; -.
DR   Proteomes; UP000002602; Genome.
DR   GO; GO:0044177; C:host cell Golgi apparatus; IEA:UniProtKB-SubCell.
DR   GO; GO:0044196; C:host cell nucleolus; IEA:UniProtKB-SubCell.
DR   InterPro; IPR002580; Herpes_UL24.
DR   Pfam; PF01646; Herpes_UL24; 1.
PE   2: Evidence at transcript level;
KW   Host cytoplasm; Host Golgi apparatus; Host nucleus; Late protein;
KW   Reference proteome; Virion.
FT   CHAIN           1..258
FT                   /note="Protein UL24 homolog"
FT                   /id="PRO_0000115988"
SQ   SEQUENCE   258 AA;  28975 MW;  1D3F7D9A84FC510B CRC64;
     MSASRIRAKC FRLGQRCHTR FYDVLKKDID NVRRGFADAF NPRLAKLLSP LSHVDVQRAV
     RISMSFEVNL GRRRPDCVCI IQTESSGAGK TVCFIVELKS CRFSANIHTP TKYHQFCEGM
     RQLRDTMALI KETTPTGSDE IMVTPLLVFV SQRGLNLLQV TRLPPKVIHG NLVMLASHLE
     NVAEYTPPIR SVRERRRLCK KKIHVCSLAK KRAKSCHRSA LTKFEENAAC GVDLPLRRPS
     LGACGGILQS ITGMFSHG