ID   UL25_HHV6G              Reviewed;         378 AA.
AC   P52536;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   23-FEB-2022, entry version 61.
DE   RecName: Full=Virion-packaging protein UL25 homolog;
DE   Flags: Fragment;
GN   Name=U50; Synonyms=LF3;
OS   Human herpesvirus 6A (strain GS) (HHV-6 variant A) (Human B lymphotropic
OS   virus).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Roseolovirus.
OX   NCBI_TaxID=10369;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1654455; DOI=10.1128/jvi.65.10.5597-5604.1991;
RA   Josephs S.F., Ablashi D.V., Salahuddin S.Z., Jagodzinski L.L.,
RA   Wong-Staal F., Gallo R.C.;
RT   "Identification of the human herpesvirus 6 glycoprotein H and putative
RT   large tegument protein genes.";
RL   J. Virol. 65:5597-5604(1991).
CC   -!- FUNCTION: Plays a role at the late stage in the encapsidation of viral
CC       DNA, assuring correct genome cleavage and presumably stabilizing
CC       capsids that contain full-lengtht viral genomes. Located on the
CC       external vertices of the T=16 icosahedric capsid, may bind together the
CC       tegument and the capsid through interaction with large tegument protein
CC       U31 (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Heterodimerizes with packaging protein U64. Interacts with
CC       major capsid protein U57 and triplex capsid protein U29, essentially at
CC       the pentamer vertices. May interact with large tegument protein U31 (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion. Host nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the herpesviridae UL25 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; S57509; AAB19777.1; -; Genomic_DNA.
DR   PIR; F56653; F56653.
DR   SMR; P52536; -.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0019028; C:viral capsid; IEA:UniProtKB-KW.
DR   GO; GO:0019072; P:viral genome packaging; IEA:InterPro.
DR   InterPro; IPR002493; Herpes_UL25.
DR   Pfam; PF01499; Herpes_UL25; 1.
PE   3: Inferred from homology;
KW   Capsid protein; Host nucleus; Viral genome packaging;
KW   Viral release from host cell; Virion.
FT   CHAIN           1..>378
FT                   /note="Virion-packaging protein UL25 homolog"
FT                   /id="PRO_0000115997"
FT   NON_TER         378
SQ   SEQUENCE   378 AA;  43459 MW;  BE8B2EF416270AB6 CRC64;
     MAQCNLFYQY PITPILEGHV RNILICTEKD VEKLQSQSSL RLREKIDQGH RDKLLRMRLK
     TELDALQKKM QKDSDVLNSH LKAIEDALLF TNDGEVNVET KADAQLIPKS PEKLEKFNQV
     AITPLDPFIR FTDDFRGEMI NTFFNNAQMW NFTFGSWFYK LKRVFYNEPG LRRALKLTNV
     DSLTISKELL AVTVNALEQA TVYPIFGSEM SDLEAALCIL AAFYSTYENS QIDERTTLVD
     VITLLPVIFR LLGSEITALK NVSPSGTYFG FNDPSCMKFF VPMRKGKHYA ENTFGNHVLI
     KMLLGRGVMQ KIPGEKISQN FDVEARLHGA IKNDVLVYWT YQLMRPKLGN NVPIFIHDQH
     YLRSGLVAIE SLFLLWRI