ID   UL26_HCMVA              Reviewed;         222 AA.
AC   P16762; Q7M6Q7;
DT   01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT   20-JAN-2009, sequence version 2.
DT   02-DEC-2020, entry version 67.
DE   RecName: Full=Tegument protein UL26;
GN   Name=UL26;
OS   Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Cytomegalovirus.
OX   NCBI_TaxID=10360;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=2161319; DOI=10.1007/978-3-642-74980-3_6;
RA   Chee M.S., Bankier A.T., Beck S., Bohni R., Brown C.M., Cerny R.,
RA   Horsnell T., Hutchison C.A. III, Kouzarides T., Martignetti J.A.,
RA   Preddie E., Satchwell S.C., Tomlinson P., Weston K.M., Barrell B.G.;
RT   "Analysis of the protein-coding content of the sequence of human
RT   cytomegalovirus strain AD169.";
RL   Curr. Top. Microbiol. Immunol. 154:125-169(1990).
RN   [2]
RP   GENOME REANNOTATION.
RX   PubMed=12533697; DOI=10.1099/vir.0.18606-0;
RA   Davison A.J., Dolan A., Akter P., Addison C., Dargan D.J., Alcendor D.J.,
RA   McGeoch D.J., Hayward G.S.;
RT   "The human cytomegalovirus genome revisited: comparison with the chimpanzee
RT   cytomegalovirus genome.";
RL   J. Gen. Virol. 84:17-28(2003).
RN   [3]
RP   ERRATUM OF PUBMED:12533697.
RA   Davison A.J., Dolan A., Akter P., Addison C., Dargan D.J., Alcendor D.J.,
RA   McGeoch D.J., Hayward G.S.;
RL   J. Gen. Virol. 84:1053-1053(2003).
RN   [4]
RP   IDENTIFICATION, FUNCTION, SUBCELLULAR LOCATION, AND ALTERNATIVE INITIATION.
RX   PubMed=11967300; DOI=10.1128/jvi.76.10.4836-4847.2002;
RA   Stamminger T., Gstaiger M., Weinzierl K., Lorz K., Winkler M.,
RA   Schaffner W.;
RT   "Open reading frame UL26 of human cytomegalovirus encodes a novel tegument
RT   protein that contains a strong transcriptional activation domain.";
RL   J. Virol. 76:4836-4847(2002).
RN   [5]
RP   IDENTIFICATION.
RX   PubMed=15452216; DOI=10.1128/jvi.78.20.10960-10966.2004;
RA   Varnum S.M., Streblow D.N., Monroe M.E., Smith P., Auberry K.J.,
RA   Pasa-Tolic L., Wang D., Camp D.G. II, Rodland K., Wiley S., Britt W.,
RA   Shenk T., Smith R.D., Nelson J.A.;
RT   "Identification of proteins in human cytomegalovirus (HCMV) particles: the
RT   HCMV proteome.";
RL   J. Virol. 78:10960-10966(2004).
RN   [6]
RP   ERRATUM OF PUBMED:15452216.
RA   Varnum S.M., Streblow D.N., Monroe M.E., Smith P., Auberry K.J.,
RA   Pasa-Tolic L., Wang D., Camp D.G. II, Rodland K., Wiley S., Britt W.,
RA   Shenk T., Smith R.D., Nelson J.A.;
RL   J. Virol. 78:13395-13395(2004).
CC   -!- FUNCTION: Plays a role in the inhibition of host NF-kappa-B. This
CC       inhibition affects both the canonical and the non-canonical pathways.
CC       Blocks the induction of host IKK phosphorylation. May also influence
CC       the normal phosphorylation state of several tegument proteins including
CC       pp28 in virions. {ECO:0000250|UniProtKB:F5HGG3,
CC       ECO:0000269|PubMed:11967300}.
CC   -!- SUBCELLULAR LOCATION: Virion tegument {ECO:0000269|PubMed:11967300}.
CC       Host nucleus {ECO:0000250|UniProtKB:F5HGG3}. Note=Also found in dense
CC       bodies. {ECO:0000250|UniProtKB:F5HGG3}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative initiation; Named isoforms=2;
CC       Name=27kDa;
CC         IsoId=P16762-1; Sequence=Displayed;
CC       Name=21kDa;
CC         IsoId=P16762-2; Sequence=VSP_036205;
CC   -!- MISCELLANEOUS: Isoform 21 kDa is first detected at 6 hours
CC       postinfection. Its expression increases at later times, when the
CC       additional 27kDa isoform is also be observed.
CC   -!- SIMILARITY: Belongs to the herpesviridae US22 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAA35425.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=DAA00130.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; X17403; CAA35425.1; ALT_INIT; Genomic_DNA.
DR   EMBL; BK000394; DAA00130.1; ALT_INIT; Genomic_DNA.
DR   PIR; S09789; S09789.
DR   Proteomes; UP000008991; Genome.
DR   Proteomes; UP000008992; Genome.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0019033; C:viral tegument; IEA:UniProtKB-SubCell.
DR   InterPro; IPR003360; US22-like.
DR   Pfam; PF02393; US22; 1.
PE   3: Inferred from homology;
KW   Activator; Alternative initiation; Host nucleus; Reference proteome;
KW   Virion; Virion tegument.
FT   CHAIN           1..222
FT                   /note="Tegument protein UL26"
FT                   /id="PRO_0000115315"
FT   VAR_SEQ         1..34
FT                   /note="Missing (in isoform 21kDa)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_036205"
SQ   SEQUENCE   222 AA;  24867 MW;  2111A51A3400B398 CRC64;
     MYAVFGLTRS EVTPHEAAAA RYKHRGVIDR QGAAMTSRRA PDGGLNLDDF MRRQRGRHLD
     LPYPRGYTLF VCDVEETILT PRDVEYWKLL VVTQGQLRVI GTIGLANLFS WDRSVAGVAA
     DGSVLCYEIS RENFVVRAAD SLPQLLERGL LHSYFEDVER AAQGRLRHGN RSGLRRDADG
     QVIRESACYV SRVLLRHRVT PGKQEITDAM FEAGNVPSAL LP