ID   UL26_HCMVM              Reviewed;         222 AA.
AC   F5HGG3;
DT   13-JUN-2012, integrated into UniProtKB/Swiss-Prot.
DT   13-JUN-2012, sequence version 2.
DT   23-FEB-2022, entry version 28.
DE   RecName: Full=Tegument protein UL26;
GN   Name=UL26;
OS   Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Cytomegalovirus.
OX   NCBI_TaxID=295027;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15105547; DOI=10.1099/vir.0.79888-0;
RA   Dolan A., Cunningham C., Hector R.D., Hassan-Walker A.F., Lee L.,
RA   Addison C., Dargan D.J., McGeoch D.J., Gatherer D., Emery V.C.,
RA   Griffiths P.D., Sinzger C., McSharry B.P., Wilkinson G.W.G., Davison A.J.;
RT   "Genetic content of wild-type human cytomegalovirus.";
RL   J. Gen. Virol. 85:1301-1312(2004).
RN   [2]
RP   FUNCTION, AND SUBCELLULAR LOCATION.
RX   PubMed=16537622; DOI=10.1128/jvi.80.7.3541-3548.2006;
RA   Munger J., Yu D., Shenk T.;
RT   "UL26-deficient human cytomegalovirus produces virions with
RT   hypophosphorylated pp28 tegument protein that is unstable within newly
RT   infected cells.";
RL   J. Virol. 80:3541-3548(2006).
RN   [3]
RP   FUNCTION.
RX   PubMed=25275128; DOI=10.1128/jvi.02552-14;
RA   Mathers C., Schafer X., Martinez-Sobrido L., Munger J.;
RT   "The human cytomegalovirus UL26 protein antagonizes NF-kappaB activation.";
RL   J. Virol. 88:14289-14300(2014).
CC   -!- FUNCTION: Plays a role in the inhibition of host NF-kappa-B. This
CC       inhibition affects both the canonical and the non-canonical pathways.
CC       Blocks the induction of host IKK phosphorylation. May also influence
CC       the normal phosphorylation state of several tegument proteins including
CC       pp28 in virions. {ECO:0000269|PubMed:16537622,
CC       ECO:0000269|PubMed:25275128}.
CC   -!- SUBCELLULAR LOCATION: Virion tegument {ECO:0000250|UniProtKB:P16762}.
CC       Host nucleus {ECO:0000269|PubMed:16537622}. Note=Also found in dense
CC       bodies.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative initiation; Named isoforms=2;
CC       Name=27kDa;
CC         IsoId=F5HGG3-1; Sequence=Displayed;
CC       Name=21kDa;
CC         IsoId=F5HGG3-2; Sequence=VSP_043922;
CC   -!- SIMILARITY: Belongs to the herpesviridae US22 family. {ECO:0000305}.
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DR   EMBL; AY446894; AAR31591.1; -; Genomic_DNA.
DR   RefSeq; YP_081485.1; NC_006273.2.
DR   PRIDE; F5HGG3; -.
DR   DNASU; 3077445; -.
DR   GeneID; 3077445; -.
DR   KEGG; vg:3077445; -.
DR   Reactome; R-HSA-9609690; HCMV Early Events.
DR   Reactome; R-HSA-9610379; HCMV Late Events.
DR   Proteomes; UP000000938; Genome.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0019033; C:viral tegument; TAS:Reactome.
DR   InterPro; IPR003360; US22-like.
DR   Pfam; PF02393; US22; 1.
PE   3: Inferred from homology;
KW   Activator; Alternative initiation; Host nucleus; Host-virus interaction;
KW   Reference proteome; Virion; Virion tegument.
FT   CHAIN           1..222
FT                   /note="Tegument protein UL26"
FT                   /id="PRO_0000417843"
FT   VAR_SEQ         1..34
FT                   /note="Missing (in isoform 21kDa)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_043922"
SQ   SEQUENCE   222 AA;  24867 MW;  8CC0B9D429C6C02E CRC64;
     MYAVFGLTRS EVTPHEAAAA RYKHRGVIDR RGAAMTSRRA PDGGLNLDDF MRRQRGRHLD
     LPYPRGYTLF VCDVEETILT PRDVEYWKLL VVTQGQLRVI GTIGLANLFS WDRSVAGVAA
     DGSVLCYEIS RENFVVRAAD SLPQLLERGL LHSYFEDVER AAQGRLRHGN RSGLRRDADG
     QVIRESACYV SRALLRHRVT PGKQEITDAM FEAGNVPSAL LP