ID   UL27_HCMVA              Reviewed;         608 AA.
AC   P16763; Q7M6Q6;
DT   01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1990, sequence version 1.
DT   23-FEB-2022, entry version 54.
DE   RecName: Full=Protein UL27;
GN   Name=UL27;
OS   Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Cytomegalovirus.
OX   NCBI_TaxID=10360;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=2161319; DOI=10.1007/978-3-642-74980-3_6;
RA   Chee M.S., Bankier A.T., Beck S., Bohni R., Brown C.M., Cerny R.,
RA   Horsnell T., Hutchison C.A. III, Kouzarides T., Martignetti J.A.,
RA   Preddie E., Satchwell S.C., Tomlinson P., Weston K.M., Barrell B.G.;
RT   "Analysis of the protein-coding content of the sequence of human
RT   cytomegalovirus strain AD169.";
RL   Curr. Top. Microbiol. Immunol. 154:125-169(1990).
RN   [2]
RP   GENOME REANNOTATION.
RX   PubMed=12533697; DOI=10.1099/vir.0.18606-0;
RA   Davison A.J., Dolan A., Akter P., Addison C., Dargan D.J., Alcendor D.J.,
RA   McGeoch D.J., Hayward G.S.;
RT   "The human cytomegalovirus genome revisited: comparison with the chimpanzee
RT   cytomegalovirus genome.";
RL   J. Gen. Virol. 84:17-28(2003).
RN   [3]
RP   ERRATUM OF PUBMED:12533697.
RA   Davison A.J., Dolan A., Akter P., Addison C., Dargan D.J., Alcendor D.J.,
RA   McGeoch D.J., Hayward G.S.;
RL   J. Gen. Virol. 84:1053-1053(2003).
CC   -!- FUNCTION: Promotes a cell cycle arrest in G0/G1 by inducing the
CC       proteasomal degradation of host histone acetyltransferase KAT5/Tip60.
CC       {ECO:0000250|UniProtKB:Q6SWA4}.
CC   -!- SUBUNIT: Interacts with host KAT5, PSME3 and EP400.
CC       {ECO:0000250|UniProtKB:Q6SWA4}.
CC   -!- SUBCELLULAR LOCATION: Host nucleus {ECO:0000250|UniProtKB:Q6SWA4}. Host
CC       nucleus, host nucleolus {ECO:0000250|UniProtKB:Q6SWA4}.
CC   -!- SIMILARITY: Belongs to the herpesviridae U4 family. {ECO:0000305}.
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DR   EMBL; X17403; CAA35426.1; -; Genomic_DNA.
DR   EMBL; BK000394; DAA00131.1; -; Genomic_DNA.
DR   PIR; S09790; S09790.
DR   PRIDE; P16763; -.
DR   Proteomes; UP000008991; Genome.
DR   Proteomes; UP000008992; Genome.
DR   GO; GO:0044196; C:host cell nucleolus; IEA:UniProtKB-SubCell.
DR   InterPro; IPR010302; U5-like_protein_herpesevirus.
DR   Pfam; PF05999; Herpes_U5; 1.
PE   3: Inferred from homology;
KW   Host nucleus; Reference proteome.
FT   CHAIN           1..608
FT                   /note="Protein UL27"
FT                   /id="PRO_0000116312"
FT   REGION          1..33
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..15
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        17..33
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   608 AA;  69220 MW;  81225A5D00E2980E CRC64;
     MNPVDQPPPP LPTQQPEEQA KEDHDDGDER LFRDPLTTYE YLDDCRDDEE FCHQFLRAYL
     TPIRNRQEAV RAGLLCRTPE DLAAAGGQKK KTPAPKHPKH AMVYIRRSCL VHSACATAHG
     KYDIRGLTLE SDLAVWAALR GVPLPPDPQH FRWLNAGAFR RLVHEAQYLP EISRAAKRIA
     LAVATGQYVV CTLLDYKTFG TRTHYLRQLC SMTEELYLRL DGTLCLFLEP EERELIGRCL
     PAALCRGLPV KYRTHRAAVF FHATFMARAE AALKDLYAAF CECGDGRDNG GNHDGNHDGN
     DHSSLSPSAV ASHHSRLEHA ELRLERNRHL GAFHLPAIRH LTAGDVARVQ DSVSRDLGFA
     DWSQTLIDDY FLLPAGWACA NPRRGYAMYL ASNAVLALRI IRLLRASIRH EYTACIRMLS
     GDVQRLIRLF KGEAALLRKG LAQNPVQRRE LSRFRKHVHD LKRIRFTEDT FVETFCDFLE
     LVQRIPDYRS VSLRIKRELL CLHVFKLRRG CRAPPTPETA RVQRLLWHSL RHGDAPQDRT
     RLPQFSSALS DAELSNHANR CRRKAPLELG PAVVAAPGPS VRYRAHIQKF ERLHVRRFRP
     HEVGGHAT