ID   UL27_HCMVM              Reviewed;         608 AA.
AC   Q6SWA4; D2K3J6;
DT   11-JUL-2012, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   23-FEB-2022, entry version 51.
DE   RecName: Full=Protein UL27;
GN   Name=UL27;
OS   Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Cytomegalovirus.
OX   NCBI_TaxID=295027;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15105547; DOI=10.1099/vir.0.79888-0;
RA   Dolan A., Cunningham C., Hector R.D., Hassan-Walker A.F., Lee L.,
RA   Addison C., Dargan D.J., McGeoch D.J., Gatherer D., Emery V.C.,
RA   Griffiths P.D., Sinzger C., McSharry B.P., Wilkinson G.W.G., Davison A.J.;
RT   "Genetic content of wild-type human cytomegalovirus.";
RL   J. Gen. Virol. 85:1301-1312(2004).
RN   [2]
RP   SUBCELLULAR LOCATION.
RX   PubMed=21906628; DOI=10.1016/j.antiviral.2011.08.019;
RA   Hakki M., Drummond C., Houser B., Marousek G., Chou S.;
RT   "Resistance to maribavir is associated with the exclusion of pUL27 from
RT   nucleoli during human cytomegalovirus infection.";
RL   Antiviral Res. 92:313-318(2011).
RN   [3]
RP   FUNCTION, SUBCELLULAR LOCATION, AND INTERACTION WITH HOST PSME3; KAT5 AND
RP   EP400.
RX   PubMed=21320693; DOI=10.1016/j.chom.2011.01.006;
RA   Reitsma J.M., Savaryn J.P., Faust K., Sato H., Halligan B.D., Terhune S.S.;
RT   "Antiviral inhibition targeting the HCMV kinase pUL97 requires pUL27-
RT   dependent proteasomal degradation of Tip60 acetyltransferase and cell-cycle
RT   arrest.";
RL   Cell Host Microbe 9:103-114(2011).
CC   -!- FUNCTION: Promotes a cell cycle arrest in G0/G1 by inducing the
CC       proteasomal degradation of host histone acetyltransferase KAT5/Tip60.
CC       {ECO:0000269|PubMed:21320693}.
CC   -!- SUBUNIT: Interacts with host KAT5, PSME3 and EP400.
CC       {ECO:0000269|PubMed:21320693}.
CC   -!- SUBCELLULAR LOCATION: Host nucleus {ECO:0000269|PubMed:21320693}. Host
CC       nucleus, host nucleolus {ECO:0000269|PubMed:21906628}.
CC   -!- SIMILARITY: Belongs to the herpesviridae U4 family. {ECO:0000305}.
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DR   EMBL; AY446894; AAR31592.1; -; Genomic_DNA.
DR   RefSeq; YP_081486.1; NC_006273.2.
DR   BioGRID; 1678002; 27.
DR   PRIDE; Q6SWA4; -.
DR   GeneID; 3077449; -.
DR   KEGG; vg:3077449; -.
DR   Reactome; R-HSA-9609690; HCMV Early Events.
DR   Proteomes; UP000000938; Genome.
DR   GO; GO:0044196; C:host cell nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0039646; P:modulation by virus of host G0/G1 transition checkpoint; IEA:UniProtKB-KW.
DR   InterPro; IPR010302; U5-like_protein_herpesevirus.
DR   Pfam; PF05999; Herpes_U5; 1.
PE   1: Evidence at protein level;
KW   G0/G1 host cell cycle checkpoint dysregulation by virus; Host nucleus;
KW   Host-virus interaction; Modulation of host cell cycle by virus;
KW   Reference proteome.
FT   CHAIN           1..608
FT                   /note="Protein UL27"
FT                   /id="PRO_0000418281"
FT   REGION          1..33
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..15
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        17..33
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   608 AA;  69143 MW;  81CB97B6FDCF3F31 CRC64;
     MNPVDQPPPP PLTQQPEEQA KEDHDDGDER LFRDPLTTYE YLDDCRDDEE FCHQFLRAYL
     TPIRNRQEAV RAGLLCRTPE DLAAAGGQKR KTPAPKHPKH AMVYIRRSCL VHSACATAHG
     KYDIRGLTLE SDLAVWAALR GVPLPPDPQH FRWLNAGAFR RLVHEAQYLP EISRAAKRIA
     LAVATGQYVV CTLLDYKTFG TRTHYLRQLC SMTEELYLRL DGTLCLFLEP EERELIGRCL
     PAALCRGLPV KYRTHRAAVF FHATFMARAE AALKDLYAAF CECGDGRDDG GNHNGNYGGG
     DHSSLSPSAV ASHHSRLEHA ELRLERNRHL GAFHLPAIRH LTAGDVARVQ DSVSRDLGFA
     DWSQTLVDDY FLLPAGWACA NPRRGYAMYL ASNAVLALRI IRLLRASIRH EYTACIRMLS
     GDVQRLIRLF KGEAALLRKG LAQNPVQRRE LSRFRKHVHD LKRIRFTEDT FVETFCDFLE
     LVQRIPDYRS VSLRIKRELL CLHVFKLRRG CRAPPTPEAV RVQRLLWHSL RHGDAPQDRT
     RLPQFSSALS DAELSNHANR CRRKAPLELG PAVVAAPGPS VRYRAHIQKF ERLHVRRFRP
     HEVGGHAT